What are the 3 ingredients? HGH, possibly metformin and what else? The article does not clearly state.
No post body was provided.
In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
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Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#22This article is a bit old (like the other comment about missing year tag says). I think there's newer news that AKG, an easy to get and cheap supplement, has anti-aging effects with no known issues. https://www.science.org/content/article/bodybuilding-supplem...
Anti-aging effects in mice*
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#23What are the 3 ingredients? HGH, possibly metformin and what else? The article does not clearly state.
dehydroepiandrosterone (DHEA)
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#24What does it really mean to rewind a persons age? Does hair get less gray, does skin get less wrinkly, does cartilage regrow?
This is a good question:
> Horvath used four different epigenetic clocks to assess each patient’s biological age, and he found significant reversal for each trial participant in all of the tests.
Presumably the "epigenetic clocks" are correlated with age, but it's not clear if changes to the epigenetic clocks causes aging, or aging causes changes to the epigenetic clocks. (Maybe it's both?) Is this like overhauling the engine in an old car to make it function like new, or is it more like rolling back the odometer to make it seem new?
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#25For anyone interested in the topic, I'd encourage reading "Lifespan" by David A. Sinclair. As someone with little to no-knowledge about aging (other than feeling the effects of aging on myself) I found it very instructive on how our aging clock works and what are some of the ongoing studies to slow down or revert aging.
I can the recommend recent interview with him on the The Knowledge Project podcast. Had a lot of aha-moments listening to that.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#26You can do this at home, except for the little inconvenience that growth hormone is a scheduled drug. I wonder what the results would be with just growth hormone. Let's ask Sylvester Stallone[1] who looks great for 75 and got caught trying to get into Australia with illicit Growth Hormone a while ago[2]. [1] https://en.wikipedia.org/wiki/Sylvester_Stallone [2] https://abcnews.go.com/Health/ActiveAging/story?id=317601…
GH by itself decreases insulin sensitivity, aggravates insulin resistance, and may significantly increase cancer risk.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#27This article is a bit old (like the other comment about missing year tag says). I think there's newer news that AKG, an easy to get and cheap supplement, has anti-aging effects with no known issues. https://www.science.org/content/article/bodybuilding-supplem...
Anti-aging effects in mice*
We've got to be careful or we're going to end up with super-intelligent immortal mice!
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#28Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.
Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)
#29Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.
You might change your mind when you're older. And wealthier.