Antiplatelet and anticoagulant therapy resolves long covid in 24 patients • Hacker News Board

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#21

Post by nykiwi » Wed, Jan 05, 2022, 3:22 PM UTC

LinuxBender wrote: post #11

Are there by chance any similar tests on long covid patients using the enzymes Serrapeptase and Nattokinase? Or any of the other 30 or so related enzymes? Asking because Natto has the nice side benefit of binding to ACE2 and it is super easy to acquire. These enzymes are also Fibrinolytics. As a related question, how is Japan doing in terms of long covid cases relative to everywhere else? They eat a lot of Natto.

Thanks for this comment, I found it very interesting and now I want to learn about it all. Thanks :)

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#22

Post by phkahler » Wed, Jan 05, 2022, 3:22 PM UTC

open-source-ux wrote: post #12

JohnJamesRambo wrote: post #5

I think I’m going to start taking aspirin. Oddly enough I took that a few times because I didn’t have ibuprofen and I do feel like it helped a lot with the weird long symptoms I am experiencing. I’m triple vaccinated before anyone asks. I haven’t tested positive for Covid on rapid tests but a lot of people seem to be in the boat I’m in right now.

" I think I’m going to start taking aspirin " In the UK there is a large, ongoing clinical trial called 'RECOVER' to test different COVID treaments for hospitalised COVID patients . One of the trials included giving hospitalised patients aspirin. The trial was not looking at the treatment of long-covid symptoms (at least not directly in hospital patients). "A total of 7351 patients were randomised to aspirin 150 mg o…

>> RECOVERY trial finds aspirin does not improve survival for patients hospitalised with COVID-19

How is survival defined? Do they mean "gets released from hospital vs. dies in hospital"? Because it seems a lot of things that can reduce severity of Covid (including vitamin D for example) don't change much at the last minute when you're at deaths door.

In this case, we're talking about long Covid symptoms so it would seem a reduction in 1-year mortality should be the deciding factor (since Severe Covid patients who "survive" still have significantly increase mortality over the next year).

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#23

Post by cinntaile » Wed, Jan 05, 2022, 3:22 PM UTC

open-source-ux wrote: post #12

JohnJamesRambo wrote: post #5

I think I’m going to start taking aspirin. Oddly enough I took that a few times because I didn’t have ibuprofen and I do feel like it helped a lot with the weird long symptoms I am experiencing. I’m triple vaccinated before anyone asks. I haven’t tested positive for Covid on rapid tests but a lot of people seem to be in the boat I’m in right now.

" I think I’m going to start taking aspirin " In the UK there is a large, ongoing clinical trial called 'RECOVER' to test different COVID treaments for hospitalised COVID patients . One of the trials included giving hospitalised patients aspirin. The trial was not looking at the treatment of long-covid symptoms (at least not directly in hospital patients). "A total of 7351 patients were randomised to aspirin 150 mg o…

He's not talking about using aspirin as a treatment for when you are hospitalised due to covid.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#24

Post by [deleted] » Wed, Jan 05, 2022, 3:24 PM UTC

criddell wrote: post #15

open-source-ux wrote: post #12

Earlier quoted context omitted.

" I think I’m going to start taking aspirin " In the UK there is a large, ongoing clinical trial called 'RECOVER' to test different COVID treaments for hospitalised COVID patients . One of the trials included giving hospitalised patients aspirin. The trial was not looking at the treatment of long-covid symptoms (at least not directly in hospital patients). "A total of 7351 patients were randomised to aspirin 150 mg o…

If aspirin doesn't improve survival, does that mean it also will not help with COVID symptoms?

[deleted]

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#25

Post by swayvil » Wed, Jan 05, 2022, 3:24 PM UTC

Could covid not actually be just a disease?

Maybe it's a disease + chronic unhealth. Due to age, pollution, obesity, bad diet, sitting on yr butt too much and/or etc

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#26

Post by cdrini » Wed, Jan 05, 2022, 3:27 PM UTC

open-source-ux wrote: post #12

JohnJamesRambo wrote: post #5

I think I’m going to start taking aspirin. Oddly enough I took that a few times because I didn’t have ibuprofen and I do feel like it helped a lot with the weird long symptoms I am experiencing. I’m triple vaccinated before anyone asks. I haven’t tested positive for Covid on rapid tests but a lot of people seem to be in the boat I’m in right now.

" I think I’m going to start taking aspirin " In the UK there is a large, ongoing clinical trial called 'RECOVER' to test different COVID treaments for hospitalised COVID patients . One of the trials included giving hospitalised patients aspirin. The trial was not looking at the treatment of long-covid symptoms (at least not directly in hospital patients). "A total of 7351 patients were randomised to aspirin 150 mg o…

This doesn't feel super applicable. The body in the middle of a COVID infection vs months later is in a VERY different state. Also I don't even know if there's any mortality data for long COVID; it could just provide quality of life degradation.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#27

Post by phkahler » Wed, Jan 05, 2022, 3:27 PM UTC

deelowe wrote: post #16

open-source-ux wrote: post #12

Earlier quoted context omitted.

" I think I’m going to start taking aspirin " In the UK there is a large, ongoing clinical trial called 'RECOVER' to test different COVID treaments for hospitalised COVID patients . One of the trials included giving hospitalised patients aspirin. The trial was not looking at the treatment of long-covid symptoms (at least not directly in hospital patients). "A total of 7351 patients were randomised to aspirin 150 mg o…

It feels to me that the medical community at large looks almost exclusively at data regarding severe cases. I'm certainly no medical expert but it seems reasonable to me that the treatments for someone who is literally dying from COVID could be completely orthogonal from those who are in the early stages of the infection. My understanding of severe cases is that the body is no longer or not only fighting the virus bu…

>> It feels to me that the medical community at large looks almost exclusively at data regarding severe cases. I'm certainly no medical expert but it seems reasonable to me that the treatments for someone who is literally dying from COVID could be completely orthogonal from those who are in the early stages of the infection.

This seems to be a problem with every account of "treatment X doesn't work". They wait until someone is half dead, use X, patient dies at same rate as without X, conclude X is worthless. "preventive" or "protective" are different words than "curative" and that seems to get overlooked in a lot of cases.

Doctor A: When I see someone with Covid Symptoms I give XYZ and they never end up in the hospital.

ER Doctor: We've tried X,Y, and Z in every combination with patients on ventilators and none of that saves them with any statistical significance.

They can both be correct.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#28

Post by kybernetyk » Wed, Jan 05, 2022, 3:30 PM UTC

JohnJamesRambo wrote: post #5

I think I’m going to start taking aspirin. Oddly enough I took that a few times because I didn’t have ibuprofen and I do feel like it helped a lot with the weird long symptoms I am experiencing. I’m triple vaccinated before anyone asks. I haven’t tested positive for Covid on rapid tests but a lot of people seem to be in the boat I’m in right now.

>I think I’m going to start taking aspirin.

Hmm, this is probably hardcore anecdata and off topic but a friend of mine who got Corona pretty bad (but not hospital bad) said that once he took Aspirin his symptoms weren't that bad anymore.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#29

Post by andor » Wed, Jan 05, 2022, 3:32 PM UTC

JohnJamesRambo wrote: post #5

I think I’m going to start taking aspirin. Oddly enough I took that a few times because I didn’t have ibuprofen and I do feel like it helped a lot with the weird long symptoms I am experiencing. I’m triple vaccinated before anyone asks. I haven’t tested positive for Covid on rapid tests but a lot of people seem to be in the boat I’m in right now.

I assume you have read the hint that the authors left in the introduction for people like you:

"Such a regime must only be followed under strict and qualified medical guidance to obviate any dangers, especially haemorrhagic bleeding, and of the therapy as a whole."

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#30

Post by heyoni » Wed, Jan 05, 2022, 3:32 PM UTC

JohnJamesRambo wrote: post #5

I think I’m going to start taking aspirin. Oddly enough I took that a few times because I didn’t have ibuprofen and I do feel like it helped a lot with the weird long symptoms I am experiencing. I’m triple vaccinated before anyone asks. I haven’t tested positive for Covid on rapid tests but a lot of people seem to be in the boat I’m in right now.

Might work for Covid. Oddly enough, it was recently declared to be unsafe for long term use unless directed by a doctor since it can increase the chance of getting a stroke.

https://www.nytimes.com/2021/10/12/health/aspirin-heart-atta...