Live data from Hacker News

BNT162b2 Vaccine Booster and Mortality Due to Covid-19

nejm.org

21–30 of 71 posts

Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19

#21
There is a low risk of heart inflammation related to the Covid vaccine for young males. Is this risk the same regardless of number of booster doses that you take, or does it go up with each additional booster? If it goes up - is the function linear, slower than linear or faster then linear?

Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19

#22
post #8

Is it too early to conclude whether booster effectiveness will also wane in 6 months? I had some mild but persistent side effects from the second Pfizer dose (ear ringing and Eustachian tube dysfunction). It's gotten about 98% better - but not 100% - and I'm a bit nervous about the booster given that many people are reporting the side effects are somewhat more intense than the second shot. If the booster is the final…

antibody levels after booster are much higher compared to after second shot. there is a chance that it will last longer

Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19

#23

Earlier quoted context omitted.

I’m in a similar boat and I hate it. I did both vaccines and I’m otherwise healthy, very low risk of hospitalization or death. My workplace has said vaccination is a requirement (even though I’m remote!) and I think boosters will be part of that. I don’t want to file a religious or medical exemption because I don’t have one. I want to file a “I shouldn’t have to do this” exemption.

Two things I'm honestly curious about in your response: 1. I understand getting the vaccine is unpleasant (personally I was knocked out for 36 hours after the second dose with a high fever and body aches), but the linked study showed that the booster lowered chances of death by 90%. Yes, things like age and underlying health have a big impact, but many seemingly healthy people have either died or been hospitalized fr…

> why wouldn't you want to get something that showed such high efficacy against death and hospitalization that had such a low, temporally finite cost?

Because they've already determined that their current health is already highly effective at keeping them out of hospital and death.

So you want them decrease their risk from 0.2% to 0.1% and in exchange expose them to a vaccine that's:

- Expires in a few months

- They've already had a history of reacting to (further shots always worse)

- No one takes liability for

- Relatively has higher risk of side effects among their profile

- Unknown long term risk

It doesn't seem like a good deal

Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19

#24
post #20
post #12

Earlier quoted context omitted.

How could they answer #2? Boosters have only been a thing for, what, a couple months now?

Israel is effectively forcing everyone to be at the 4th booster by now. Guess how things are looking? Ready to take the 5th booster shortly. Lol, “never again” and Nuremberg code are just words easily forgotten.

Israel is still doing 3rd shot (aka booster). Nobody forcing there 4th booster

Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19

#25
I want to know what percentage of those who died also suffered form comorbidities. Also this is for people aged 50 and above, what about healthy young people?

Do the math, death rate is 0.008% (boosted) vs 0.16% (unboosted) for aged 50 and above. Still super low. And we're getting better and better at treating this thing.

Get it if you *want* it. Don't if you don't. I do not want it or need it thank you very much.

Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19

#26
post #17

Here's a summary, quoted from the article: > RESULTS > A total of 843,208 participants met the eligibility criteria, of whom 758,118 (90%) received the booster during the 54-day study period. Death due to Covid-19 occurred in 65 participants in the booster group (0.16 per 100,000 persons per day) and in 137 participants in the nonbooster group (2.98 per 100,000 persons per day). The adjusted hazard ratio for death du…

> I'll take a 90% lower mortality rate any day. Really? Any day? Read the part you quoted carefully: the death rate in the control group is 3 per 100,000. And if you read the rest of the paper, you'll see that the study population was entirely over age 50. Remember that the risk of death from Covid-19 goes up exponentially with age -- something like 90% of all fatalities are over age 50 [1]. If you're in the typical…

Yes. Any day, and twice on Sunday. If 90% of COVID deaths in the US could have been prevented (in fact, many could have been)[0][1], that cuts this whole thing down to a very bad flu season, comparable to the 1957 flu pandemic [3].

Would you rather not cut your risk by 90%?

Edit: Incidentally, I have been hit by cars while walking 3 times. No injuries, luckily, since they were very low speed impacts.

Why are you seemingly advocating against something (getting a booster shot) that's also extremely unlikely to harm you?

---

[0]: https://www.thedenverchannel.com/news/national/coronavirus/n...

[1]: https://www.kff.org/coronavirus-covid-19/issue-brief/covid-1...

[2]: https://en.wikipedia.org/wiki/1957%E2%80%931958_influenza_pa...

Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19

#27
post #18
post #8

Is it too early to conclude whether booster effectiveness will also wane in 6 months? I had some mild but persistent side effects from the second Pfizer dose (ear ringing and Eustachian tube dysfunction). It's gotten about 98% better - but not 100% - and I'm a bit nervous about the booster given that many people are reporting the side effects are somewhat more intense than the second shot. If the booster is the final…

Maybe you can consider another vaccine as a booster if this one did not acted well on you? I don't see how the booster is guaranteed to be the final answer as the virus keeps mutating and spreading among the very large unvaccinated population. I personally think that it will become endemic, thanks to the vaccine we would have enough immunity to keep us out of hospital and each time we get the virus it would act as a…

Its actually the 'leaky' vaccine that is causing the problematic mutations. In the same sense that bacteria mutate to evade antibiotics, the virus mutates to evade the vaccine.

https://www.youtube.com/watch?v=iwPKnOhJRYg&list=PL2FOgJ3tfG...

Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19

#28

Earlier quoted context omitted.

Two things I'm honestly curious about in your response: 1. I understand getting the vaccine is unpleasant (personally I was knocked out for 36 hours after the second dose with a high fever and body aches), but the linked study showed that the booster lowered chances of death by 90%. Yes, things like age and underlying health have a big impact, but many seemingly healthy people have either died or been hospitalized fr…

> why wouldn't you want to get something that showed such high efficacy against death and hospitalization that had such a low, temporally finite cost? Because they've already determined that their current health is already highly effective at keeping them out of hospital and death. So you want them decrease their risk from 0.2% to 0.1% and in exchange expose them to a vaccine that's: - Expires in a few months - They'…

All valid points except the last one. Unknown long term risk is silly because Covid and Omicron specifically also come with unknown long term risk.

Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19

#29

Earlier quoted context omitted.

Two things I'm honestly curious about in your response: 1. I understand getting the vaccine is unpleasant (personally I was knocked out for 36 hours after the second dose with a high fever and body aches), but the linked study showed that the booster lowered chances of death by 90%. Yes, things like age and underlying health have a big impact, but many seemingly healthy people have either died or been hospitalized fr…

> why wouldn't you want to get something that showed such high efficacy against death and hospitalization that had such a low, temporally finite cost? Because they've already determined that their current health is already highly effective at keeping them out of hospital and death. So you want them decrease their risk from 0.2% to 0.1% and in exchange expose them to a vaccine that's: - Expires in a few months - They'…

Taking your points 1-by-1:

> So you want them decrease their risk from 0.2% to 0.1%

The linked study said those that had gotten a booster had 10% of the risk of those that didn't, so using your first number it would be like 0.2% to 0.02%.

> Expires in a few months

It's unknown how long the booster would last, or if after the booster the recommendation would be to move to something annual like flu shots.

> They've already had a history of reacting to (further shots always worse)

The person I responded to didn't say what their reaction was, or if it was time limited. Also, "further shots always worse" is demonstrably false, I know a couple people who had bad (yet, again very short term) side effects with the second dose and barely anything for the booster.

> No one takes liability for

The US government specifically runs a National Vaccine Injury Compensation Program, https://www.hrsa.gov/vaccine-compensation/index.html

> Relatively has higher risk of side effects among their profile

The person I responded to didn't mention this

> Unknown long term risk

Vs. the now well-known long-term risks of contracting Covid, which given its prevalence seems highly likely that your long term choices are (a) never leave your house, (b) reduce likelihood and severity of infection with a vaccine, or (c) get Covid.

Re: BNT162b2 Vaccine Booster and Mortality Due to Covid-19

#30
post #18

Earlier quoted context omitted.

Maybe you can consider another vaccine as a booster if this one did not acted well on you? I don't see how the booster is guaranteed to be the final answer as the virus keeps mutating and spreading among the very large unvaccinated population. I personally think that it will become endemic, thanks to the vaccine we would have enough immunity to keep us out of hospital and each time we get the virus it would act as a…

Its actually the 'leaky' vaccine that is causing the problematic mutations. In the same sense that bacteria mutate to evade antibiotics, the virus mutates to evade the vaccine. https://www.youtube.com/watch?v=iwPKnOhJRYg&list=PL2FOgJ3tfG...

Your source is a random YouTube video? AFAIK viruses are nothing like bacteria…
Post reply on HN