I don't yet know enough about the single founder bit, but there is one unrelated sentence that you write that gives me great pause in the way you chose to write it:
"But, if you want to do something big in the tech sector, you absolutely must be in SV for the connections, money, talent, etc."
Really? You "absolutely must" be in SV? Seems like Groupon, Foursquare, Groupme, Bitly, Grubhub, Gawker, Gilt, Kickstarter, Amazon, Tumblr etc etc etc are doing just fine not in SV.
Great companies can be started in many places. A critical mass is helpful, as is money. You can get money from anywhere. I'm from Pittsburgh. A company there (Dynamics) just raised a $35 million series B. They are doing great on "connections, money, talent, etc" in Pittsburgh. Several of your YC batchmates will leave SV for other places. They will be just fine on all those things too. You might not have been fine in NC, but there are many places you would be able to raise money, find talent, etc. We ended up rejecting some VC's that wanted us to be in Cali but ended up with terms we liked from investors we like. (We're in Chicago) I have occasionally given thought to going back to SF/SV but for our business there wouldn't be any impact other than we'd have to pay higher salaries and rent.