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‘Dancing molecules’ successfully repair severe spinal cord injuries

news.northwestern.edu

21–30 of 104 posts

Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries

#21
These kind of studies and experiments always sound so amazing, but how long would something like this take to be applicable for at least human trials ?

I understand there are so many precautions to take etc, but is there any kind of 'complete consent' one could sign to jump start stuff like that ?

Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries

#22
post #19

Based on this stimulating Axon growth, it sounds like it might help to repair the damage caused by MS. That would be amazing news. Not a cure per se, but a way to actually treat symptoms rather than just surpressing. Worryingly, they mention a few neurodegenerative diseases but not MS.

That was exactly my first thought as well.

Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries

#23

> The therapy also induces myelin to rebuild around axons and reduces glial scarring, which acts as a physical barrier that prevents the spinal cord from healing This gives the impression that this would need to be administered before any scaring takes place. It is probably not a remedy for people with old injuries.

Yeah, but this is incredible if it works at the human level.

My friend was in a car accident and a subwoofer that wasn't tied down ended up striking in him the back paralyzing him from the mid-back down. Years and years of heartache for both my friend, and the other friend who installed the subwoofer without tying it down.

There was a lot of things wrong that allowed this to happen, but knowing future people with injuries like my friend whom this therapy could save or alleviate makes me incredibly excited.

Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries

#25

> The therapy also induces myelin to rebuild around axons and reduces glial scarring, which acts as a physical barrier that prevents the spinal cord from healing This gives the impression that this would need to be administered before any scaring takes place. It is probably not a remedy for people with old injuries.

This, however, seems to suggest that the therapy actually reduces pre-existing scar tissue:

> the breakthrough therapy dramatically improved severely injured spinal cords in five key ways: (1) The severed extensions of neurons, called axons, regenerated; (2) scar tissue, which can create a physical barrier to regeneration and repair, significantly diminished;

Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries

#26
post #21

These kind of studies and experiments always sound so amazing, but how long would something like this take to be applicable for at least human trials ? I understand there are so many precautions to take etc, but is there any kind of 'complete consent' one could sign to jump start stuff like that ?

Would you, as a researcher, want to make your first attempts on human subjects? Even if someone gives you “complete consent”, it makes sense to ensure that that consent is informed and that those administering are prepared to give them care when things inevitably go wrong. At the very least, leaving all the ethical concerns aside, someone will have to pay for that care.

Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries

#27
post #3

Again mice models...

Over the last 25 years or so, there have been at least a dozen announcements of the latest miracle cure that works to repair spinal cord injury in mice. To date, none of them have translated to human efficacy. It's almost a meme at this point - like net-positive fusion being only ten years away. There appears to be a fundamental difference between mice and human nervous system injury repair modes that leads to early confidence. The spinal cords in mice essentially repair themselves if you so much as ask nicely.

The real litmus test for claims of effective spinal cord repair treatments is primate testing. If you see mice and not chimps, the treatment is probably a dead end.

Not to say this research doesn't have value - I fully support continued and rigorous research in this area - but hyperbolic claims like: "it works in mice, so it should also work in humans" aren't helping the cause.

Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries

#28
post #3

Again mice models...

...as if some sort of future rodent time travelers went back in earth's pre-history and tasked countless human-filled labs with unlocking the secrets of rodent medical science so they could, in their own time, mine the wisdom of the ancients and ensure their immortality.

Re: ‘Dancing molecules’ successfully repair severe spinal cord injuries

#29

> The therapy also induces myelin to rebuild around axons and reduces glial scarring, which acts as a physical barrier that prevents the spinal cord from healing This gives the impression that this would need to be administered before any scaring takes place. It is probably not a remedy for people with old injuries.

Maybe a dumb question but....

If scar tissue forms after an injury and blocks the area (on both sides of the nerve, I assume), like this ---x x--- . Could you then cut the scarred area away, creating "new" injury that this treatment could cure?

----x x----

---| |---

---**---

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