Interesting that they're porting it to other organisms. Different organisms have variations in ribosomes, post translational modifications and even tRNA repertoire. So it's not a guarantee that two identical DNA sequences will give identical proteins in two different organisms.
AlphaFold Protein Structure Database
21–30 of 62 posts
Re: AlphaFold Protein Structure Database
#22Gain of function researchers working for the world's militaries will use this research to figure out how to get viruses to attach to receptor sites peculiar to particular races. The people developing the antivirals will have a lot harder time countering these weapons because making antivirals that aren't poisonous in some weird way is a much harder job. If this is not the case, please let me know why, it will really help me sleep better at night.
A U.S congressional representative came out of a classified briefing recently and announced that the CCP is hard at work on race specific bioweapons.[1]
Unfortunately, I think this is the launch of a new era of weapons we're seeing right now. The biggest development in war since the atom bomb. Like the atom bomb, the big question was will we kill ourselves with this technology. Who knows?
[1]https://yournews.com/2021/07/22/2185645/rep-marjorie-taylor-...
Re: AlphaFold Protein Structure Database
#23From the abstract[1]: > After decades of effort, 17% of the total residues in human protein sequences are covered by an experimentally-determined structure. Here we dramatically expand structural coverage by applying the state-of-the-art machine learning method, AlphaFold2, at scale to almost the entire human proteome (98.5% of human proteins). [1] https://www.nature.com/articles/s41586-021-03828-1
Basically they are saying that decades of distributed protein folding was useless and everyone would have had more utility mining cryptocurrency if it existed several years earlier
But at least it inspired someone to make and release this
Re: AlphaFold Protein Structure Database
#24Gain of function researchers working for the world's militaries will use this research to figure out how to get viruses to attach to receptor sites peculiar to particular races. The people developing the antivirals will have a lot harder time countering these weapons because making antivirals that aren't poisonous in some weird way is a much harder job. If this is not the case, please let me know why, it will really…
...and many doctors will use it to attach pharmaceuticals to receptor sites of particular cancers.
Re: AlphaFold Protein Structure Database
#25From the abstract[1]: > After decades of effort, 17% of the total residues in human protein sequences are covered by an experimentally-determined structure. Here we dramatically expand structural coverage by applying the state-of-the-art machine learning method, AlphaFold2, at scale to almost the entire human proteome (98.5% of human proteins). [1] https://www.nature.com/articles/s41586-021-03828-1
Basically they are saying that decades of distributed protein folding was useless and everyone would have had more utility mining cryptocurrency if it existed several years earlier But at least it inspired someone to make and release this
Just in case you're not joking, it's worth noting that the majority of distributed molecular simulation (past and present) is spent studying "folded proteins" to discover structures of proteins that are often hidden from methods like AlphaFold (currently). For example, https://www.nature.com/articles/s41557-021-00707-0
Re: AlphaFold Protein Structure Database
#26From the abstract[1]: > After decades of effort, 17% of the total residues in human protein sequences are covered by an experimentally-determined structure. Here we dramatically expand structural coverage by applying the state-of-the-art machine learning method, AlphaFold2, at scale to almost the entire human proteome (98.5% of human proteins). [1] https://www.nature.com/articles/s41586-021-03828-1
Basically they are saying that decades of distributed protein folding was useless and everyone would have had more utility mining cryptocurrency if it existed several years earlier But at least it inspired someone to make and release this
> experimentally-determined structure
refers to structures determined by means of physical examination, with like crystallography, not to attempts at predictive computational analysis prior to AlphaFold, which were not accurate compared to AlphaFold.
Re: AlphaFold Protein Structure Database
#27Gain of function researchers working for the world's militaries will use this research to figure out how to get viruses to attach to receptor sites peculiar to particular races. The people developing the antivirals will have a lot harder time countering these weapons because making antivirals that aren't poisonous in some weird way is a much harder job. If this is not the case, please let me know why, it will really…
...and many doctors will use it to attach pharmaceuticals to receptor sites of particular cancers.
I'm thinking that the problem is is that it is much harder to develop drugs that only kill cancers very efficiently and don't harm the rest of the body than to tweak viruses that just have to keep the person alive long enough to spread the virus.
Re: AlphaFold Protein Structure Database
#28From the abstract[1]: > After decades of effort, 17% of the total residues in human protein sequences are covered by an experimentally-determined structure. Here we dramatically expand structural coverage by applying the state-of-the-art machine learning method, AlphaFold2, at scale to almost the entire human proteome (98.5% of human proteins). [1] https://www.nature.com/articles/s41586-021-03828-1
Basically they are saying that decades of distributed protein folding was useless and everyone would have had more utility mining cryptocurrency if it existed several years earlier But at least it inspired someone to make and release this
A third way in which you are wrong is that AlphaFold derives a lot of its power by referring to previously-solved protein structures, or parts of them. It doesn't fold the proteins from scratch in an "alpha-zero" way.
Re: AlphaFold Protein Structure Database
#29Earlier quoted context omitted.
Basically they are saying that decades of distributed protein folding was useless and everyone would have had more utility mining cryptocurrency if it existed several years earlier But at least it inspired someone to make and release this
A third way in which you are wrong is that AlphaFold derives a lot of its power by referring to previously-solved protein structures, or parts of them. It doesn't fold the proteins from scratch in an "alpha-zero" way.
so its more like protein folding was useless until an AI could make sense of the 17% solved variations and using that for the other 83% of proteins found in humans?
> After decades of effort, 17% of the total residues in human protein sequences are covered by an experimentally-determined structure. Here we dramatically expand structural coverage by applying the state-of-the-art machine learning method, AlphaFold2, at scale to almost the entire human proteome (98.5% of human proteins).
I just don't actually understand the quote from the article if it isn't comparing the same thing
Re: AlphaFold Protein Structure Database
#30Earlier quoted context omitted.
...and many doctors will use it to attach pharmaceuticals to receptor sites of particular cancers.
I'm thinking that the problem is is that it is much harder to develop drugs that only kill cancers very efficiently and don't harm the rest of the body than to tweak viruses that just have to keep the person alive long enough to spread the virus.
I 100% agree your point is valid. The counterargument is "Yes, people can do bad things with protein data, just as they can do bad things with a telephone, like use it to discuss a bank robbery."