MacOS has had horrible mouse input since forever.
Up until some version I could kill the acceleration curve with SteerMouse (but not the scroll acceleration), but there was still the 2 frame lag. It's also extremely distracting how you can see the UI further lagging behind the cursor when you drag windows or click buttons. Another frame or two of delay, bringing it to a total of 64ms.
I have a 1000km RTT ping that takes less than it takes MacOS to react to mouse movement. It feels like using a remote desktop.
After Big Sur, the issue got even worse, especially on external displays. CPU usage also spiked through the roof.
After developing for a while on a Windows machine with a 144hz display and a 500+hz mouse I can't go back to using MacOS. It feels like trying to use a car infotainment system by comparison.
I also couldn't get a 2019 15" MBP to work on the external display at over 100hz using DP Alt Mode over a HDMI2.0 cable. The same one works fine on my desktop or on a ThinkPad.