I don't worry about easy nukes but I do worry about easy viruses, especially now that we've seen what a pandemic can do. Virus construction is only going to become easier over time, and at some point, you could imagine any run of the mill biochem lab capable of "printing" a new strain of some infectious disease.
Activating tin-foil hat Maybe Covid was 'printed'...?
https://www.nbcnews.com/health/health-news/u-s-still-hasn-t-...