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Another French Study Looks Into The Use of Nicotine Against Covid-19

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Re: Another French Study Looks Into The Use of Nicotine Against Covid-19

#21

Post by sgtnoodle »

bird_monster wrote: post #3

> The study in question will be randomized, national and multi-center, carried out double-blind, and should involve teams from Assistance Publique – Hôpitaux de Paris, Sorbonne University and Inserm. It is expected to include approximately 1,633 medical and non-medical caregivers, working in a health establishment, non-smokers (or former smokers who have quit smoking for more than 12 months), without a history of inf…

Hydroxychloroquine has been very controversial for some reason, but it is an immunosuppressant that's been used for years to treat sarcoidosis, and severe covid is a very similar inflammatory disease.

Re: Another French Study Looks Into The Use of Nicotine Against Covid-19

#22

Post by spacehome »

helsinki wrote: post #17

As someone who has been wearing nicotine patches every day for several years, the thought of the general population buying up my life source is terrifying. I now have a 400 day supply arriving tomorrow.

That’s certainly an interesting hobby.

Re: Another French Study Looks Into The Use of Nicotine Against Covid-19

#23

Post by colechristensen »

carlmr wrote: post #14
colechristensen wrote: post #7

Earlier quoted context omitted.

A quick literature search shows ample evidence of both immune suppressing and immune promoting effects of nicotine. I didn’t see something that was a clear consensus, but it seemed like nicotine decidedly modulates the immune system. It seems whatever effects it has might do good things for covid. Nicotine isn’t evil, and even not particularly addictive when not delivered via burning leaves. (components in smoke chan…

I've been wondering about this anyway. Isn't the covid that requires hospitalization due to an overreaction of the immune system? Maybe suppressing the immune system slightly is what helps here.

One of the primary treatments is a big dose of powerful steroids to suppress the immune response.

Re: Another French Study Looks Into The Use of Nicotine Against Covid-19

#24

Post by ipsum2 »

reilly3000 wrote: post #11

There are oral nicotine products that are widely available. You can get smoking cessation lozenges at drug stores, but there are also nicotine pouches sold alongside cigarettes and snus. Some use tobacco nicotine, but many are derived from nightshade vegetables such as tomatoes. If you were considering adding nicotine into your life, this would probably be the safest choice for the throat and lungs. Receding gums and…

Smoking cessation lozenges are kinda gross, they mimic the taste of smoking.

Re: Another French Study Looks Into The Use of Nicotine Against Covid-19

#25

Post by ipsum2 »

function_seven wrote: post #4
brianjunyinchan wrote: post #2

> The daily smokers rate amongst COVID-19 patients was at 5.3%, whilst amongst the general population, the daily smokers rate was at 25.4%. Not to be macabre, but could it potentially be that more smokers die before reaching the older age range of most COVID hospitalizations?

The first paragraph says: > The researchers had estimated the rates of daily current smokers among COVID-19-infected patients and compared them to the rates of daily current smokers within the general French population, after controlling the data for sex and age. So, assuming they correctly controlled for age, then no, it’s not “anti-survivorship” bias. (“Casualty bias”?)

There could still be survivorship bias, e.g. the people who don't die from smoking have stronger lungs, and aren't affected as much by covid.

Re: Another French Study Looks Into The Use of Nicotine Against Covid-19

#26

Post by sgtnoodle »

adw wrote: post #20
sgtnoodle wrote: post #18

Lol, I've been saying this since July. Severe covid is due to organ inflammation from overaggressive immune system response, and nicotine is an immune system suppressant. The one episode of Dr. House where is was actually sarcoidosis (a systemic inflammatory disease), the patient didn't have any symptoms because of his use of chewing tobacco to manage his weight for wrestling.

You'd probably be interested in https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9... This paper points out that patients on infliximab (trade name Remicade: immune system modulator used by people with chronic autoimmune diseases, particularly IBD and rheumatoid arthritis) don't seem to be at elevated risk of severe COVID – which is surprising because these are powerful immune system suppressants.

I had to start taking immunosuppressants earlier this year, and after reading up on it I've convinced myself that it's an effective treatment for severe covid. As it happened, I essentially had a severe covid experience, but for auto-immune/ideopathic reasons. It's like my body had 2020 FOMO.

Re: Another French Study Looks Into The Use of Nicotine Against Covid-19

#27

Post by dmix »

sgtnoodle wrote: post #18

Lol, I've been saying this since July. Severe covid is due to organ inflammation from overaggressive immune system response, and nicotine is an immune system suppressant. The one episode of Dr. House where is was actually sarcoidosis (a systemic inflammatory disease), the patient didn't have any symptoms because of his use of chewing tobacco to manage his weight for wrestling.

All diseases cause inflammation, it's the bodies basic response to everything, like cuts and whatnot. That said, this may also be why they figured out certain steroids helped COVID patients by reducing this hyper reaction. I rememebr reading some steroids became a frontline treatment at some point mid way through the year at certain medical centers.

But any pathologist would have known immediately about the risks of inflammation and that being the auto-response. It would have been evaluated is what I'm assuming.

I have colitis which similarly causes artificial immune response in the digestive tract and they used steroids to help reduce the inflammation which was causing other serious problems in my body. But only during a very serious episode. Other lighter approaches are available to keep it under control.

Note: I'm not a medical expert at all and could be talking out of my ass. Just basing this on personal experience and some personal reading into pathology.

Re: Another French Study Looks Into The Use of Nicotine Against Covid-19

#28

Post by sgtnoodle »

dmix wrote: post #27
sgtnoodle wrote: post #18

Lol, I've been saying this since July. Severe covid is due to organ inflammation from overaggressive immune system response, and nicotine is an immune system suppressant. The one episode of Dr. House where is was actually sarcoidosis (a systemic inflammatory disease), the patient didn't have any symptoms because of his use of chewing tobacco to manage his weight for wrestling.

All diseases cause inflammation, it's the bodies basic response to everything, like cuts and whatnot. That said, this may also be why they figured out certain steroids helped COVID patients by reducing this hyper reaction. I rememebr reading some steroids became a frontline treatment at some point mid way through the year at certain medical centers. But any pathologist would have known immediately about the risks of…

For sure, but severe covid seems to involve a disproportionate amount of inflammation that itself causes organ damage. I think the medical term is a cytokine storm?

Re: Another French Study Looks Into The Use of Nicotine Against Covid-19

#29

Post by helsinki »

spacehome wrote: post #22
helsinki wrote: post #17

As someone who has been wearing nicotine patches every day for several years, the thought of the general population buying up my life source is terrifying. I now have a 400 day supply arriving tomorrow.

That’s certainly an interesting hobby.

feelsgoodman.jpg

Re: Another French Study Looks Into The Use of Nicotine Against Covid-19

#30

Post by kevin_thibedeau »

ipsum2 wrote: post #24
reilly3000 wrote: post #11

There are oral nicotine products that are widely available. You can get smoking cessation lozenges at drug stores, but there are also nicotine pouches sold alongside cigarettes and snus. Some use tobacco nicotine, but many are derived from nightshade vegetables such as tomatoes. If you were considering adding nicotine into your life, this would probably be the safest choice for the throat and lungs. Receding gums and…

Smoking cessation lozenges are kinda gross, they mimic the taste of smoking.

The point is to be unappealing otherwise there will be no cessation.
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