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Unraveling the role of the microbiome in major depressive disorder

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21–30 of 34 posts

Re: Unraveling the role of the microbiome in major depressive disorder

#21
post #12

It seems that microbiome research is always defended here. Perhaps it is scientific, but be aware that a multi billion dollar industry depends on "improving" the microbiome. Here's an ad in nature.com: https://www.nature.com/articles/d42473-019-00336-9

Indeed, the paper in question here was sponsored by grants to the APC Microbiome Institute. Not that that means the work isn't solid, but it's certainly something to bear in mind while reading.

Re: Unraveling the role of the microbiome in major depressive disorder

#22
post #13

Any thought on imalanced microbiome being a second order effect rather than a cause? I’d guess continued stress responses from the nervous system could cause chronic gut problems

Every time a scientific article "x may cause y" is posted, there are a couple dozen "correlation does not equal causation" retorts, as if the researchers involved were unaware of this exceedingly basic and elementary principle.

It's such a waste of comment - an intellectual platitude. Can you point specifically to how this research is flawed, or how alternative research offers a better explanation?

Re: Unraveling the role of the microbiome in major depressive disorder

#23
post #2

Maybe depressed people eat a lot of junk food.

Is your comment adding an informed opinion on this topic? Or are you perhaps smart in one area and think you can just wing an opinion on this topic? I live with someone with clinical depression. One of the most maddening things for her is the astounding number of people who have absolutely no idea what they are talking about offering "helpful" opinions. No, they aren't helpful, they are hurtful. When someone triviali…

But, if some external force compelled the person in question to run several miles every day, lift heavy weights, sleep a lot, and eat perfect food, that person would probably be meaningfully less depressed within half a year. Obviously with feedback being what it is it's not that simple, but still. Speaking as someone with clinically diagnosed depression btw. It's a lot of unpleasant effort to kill depression but it's not impossible, and it's the only way to do it. Drugs and talk therapy can help a lot but fundamentally the change has to happen of one's own volition

Re: Unraveling the role of the microbiome in major depressive disorder

#24
post #16
post #12

It seems that microbiome research is always defended here. Perhaps it is scientific, but be aware that a multi billion dollar industry depends on "improving" the microbiome. Here's an ad in nature.com: https://www.nature.com/articles/d42473-019-00336-9

The other year they were saying autism was related to the microbiome. That got too-good-to-be-true alarm bells ringing in my head for sure.

There is a lot of evidence it is related, however that's not the same thing of course as being able to modulate symptoms via the microbiome (that one poop transplant study was extremely preliminary). I think the jury is still out on that latter idea, but current probiotics surely have no effect. I hope that as this line of research continues industry will adapt and we will start to see probiotics that are A) better at actually populating the gut and B) personalized.

Re: Unraveling the role of the microbiome in major depressive disorder

#25
post #16
post #12

It seems that microbiome research is always defended here. Perhaps it is scientific, but be aware that a multi billion dollar industry depends on "improving" the microbiome. Here's an ad in nature.com: https://www.nature.com/articles/d42473-019-00336-9

The other year they were saying autism was related to the microbiome. That got too-good-to-be-true alarm bells ringing in my head for sure.

That research is still ongoing and getting funded, eg https://science.oregonstate.edu/IMPACT/2019/05/microbiologis...

Re: Unraveling the role of the microbiome in major depressive disorder

#26

Earlier quoted context omitted.

I downvoted because by the HN guidelines comments should try to be curious and interesting and because “ Please don't post shallow dismissals ”. The abstract mentions that diet affects gut microbiome and that gut microbiome has a “shaping effect” on psychiatric disorders: > “ A growing body of literature shows that the gut microbiome plays a shaping role in a variety of psychiatric disorders, including major depressi…

It's certainly shallow, but not explicitly a dismissal. It doesn't contradict the OP. That's just the closest rule cited as there isn't one that merely explicitly states "don't post unsubstantial fluff". Maybe there should be.

It's not shallow and it's not a dismissal. Just because it can be expressed in one simple sentence doesn't make it a bad idea. He never said that this is the only thing going on.

Re: Unraveling the role of the microbiome in major depressive disorder

#27
post #2

Maybe depressed people eat a lot of junk food.

Is your comment adding an informed opinion on this topic? Or are you perhaps smart in one area and think you can just wing an opinion on this topic? I live with someone with clinical depression. One of the most maddening things for her is the astounding number of people who have absolutely no idea what they are talking about offering "helpful" opinions. No, they aren't helpful, they are hurtful. When someone triviali…

He said maybe, so it's a hypothesis.

Re: Unraveling the role of the microbiome in major depressive disorder

#28

Earlier quoted context omitted.

Not sure why you're getting downvoted, this is a good point.

Imagine a HN link to a paper which summarizes various other studies for the causes of failures in auto navigation systems. Dozens of studies are cited, which covers areas such as incomplete testing due to schedule pressures, not adhering to coding guidelines for safety, lack of redundancy or self checking mechanisms, hardware failure, unanticipated overruns of scheduler time budgets due to a confluence of exceptions,…

[deleted]

Re: Unraveling the role of the microbiome in major depressive disorder

#29
Depression is a symptom of celiac disease, which is a result of gluten in the diet, another symptom of which is poor gut Microbiome health.

I bring up Celiac because 1/ I have it, and 2/ there is very little medical doubt / uncertainty / controversy about the disease.

Re: Unraveling the role of the microbiome in major depressive disorder

#30

Depression is a symptom of celiac disease, which is a result of gluten in the diet, another symptom of which is poor gut Microbiome health. I bring up Celiac because 1/ I have it, and 2/ there is very little medical doubt / uncertainty / controversy about the disease.

Hasty generalization fallacy right here.
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