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FDA grants authorization to Moderna's Covid-19 vaccine

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Re: FDA grants authorization to Moderna's Covid-19 vaccine

#21

Post by m-ee »

lisper wrote: post #20
FreakyT wrote: post #7

Glad to hear it! One key advantage of the Moderna one versus the similar Pfizer/BioNTech vaccine is that it doesn't require deep freeze storage, only regular freezing temperatures. (-90º C for Pfizer/BioNTech vs -20º C for Moderna)

Does anyone here know the reason for the difference? They're both mRNA vaccines, right? So why does one need a deep freeze and the other one not?

Different lipid nano particles, or maybe just stability testing. The vaccines could be stable at lower temperatures but the companies haven’t had time to prove it by letting the vaccine sit in a fridge for months.

Re: FDA grants authorization to Moderna's Covid-19 vaccine

#22

Post by mssundaram »

aphextron wrote: post #19
roody15 wrote: post #8

Hmm super expensive hard to transport Pfizer vaccine ... first to be approved. Next Moderna ... also super expensive second to be approved. After six months to a year ... and after making huge profits.... Then the AstraZeneca/Russian vaccine variants will be “found” to be also effective. We must first wait and let Pfizer make a few billion !!!

What exactly is wrong with allowing a company to profit from performing a literal miracle?

I don't think you'll ever see the answer to your question if that's how you're framing it

Re: FDA grants authorization to Moderna's Covid-19 vaccine

#23

Post by m-ee »

throwaway201103 wrote: post #15
eganist wrote: post #5

Earlier quoted context omitted.

> and stopped vaccinating people who already had COVID How would you propose doing this without drawing blood from every single person getting a vaccine?

Simply tell people, "if you've had COVID, don't get the vaccine" or maybe "go to the end of the line"

That’s terrible messaging given that reinfection is rare but possible and occasionally deadly. We want everyone to take it.

Re: FDA grants authorization to Moderna's Covid-19 vaccine

#24

Post by systemvoltage »

aphextron wrote: post #19
roody15 wrote: post #8

Hmm super expensive hard to transport Pfizer vaccine ... first to be approved. Next Moderna ... also super expensive second to be approved. After six months to a year ... and after making huge profits.... Then the AstraZeneca/Russian vaccine variants will be “found” to be also effective. We must first wait and let Pfizer make a few billion !!!

What exactly is wrong with allowing a company to profit from performing a literal miracle?

I think Gov should buy the vaccine and provide it for free. Private companies should rightfully charge a premium to the governments as they took: 1) Enormous risk 2) Expediency 3) Investment of talent 4) Demand is through the roof; all this even if the governments were involved in hedging the risk for spinning up manufacturing lines.

Re: FDA grants authorization to Moderna's Covid-19 vaccine

#25

Post by handmodel »

systemvoltage wrote: post #24
aphextron wrote: post #19

Earlier quoted context omitted.

What exactly is wrong with allowing a company to profit from performing a literal miracle?

I think Gov should buy the vaccine and provide it for free. Private companies should rightfully charge a premium to the governments as they took: 1) Enormous risk 2) Expediency 3) Investment of talent 4) Demand is through the roof; all this even if the governments were involved in hedging the risk for spinning up manufacturing lines.

In the US that is what is happening - no one is paying for the vaccine.

It is intellectually vapid to get worked about the fact companies are making a $15 marginal unit profit on a vaccine that has 10x the utility of the average annual physical but costs 1/10th as much.

Re: FDA grants authorization to Moderna's Covid-19 vaccine

#27

Post by garmaine »

m-ee wrote: post #21
lisper wrote: post #20

Earlier quoted context omitted.

Does anyone here know the reason for the difference? They're both mRNA vaccines, right? So why does one need a deep freeze and the other one not?

Different lipid nano particles, or maybe just stability testing. The vaccines could be stable at lower temperatures but the companies haven’t had time to prove it by letting the vaccine sit in a fridge for months.

At higher temperatures, you mean.

Re: FDA grants authorization to Moderna's Covid-19 vaccine

#28

Post by chromatin »

IfOnlyYouKnew wrote: post #12
mchusma wrote: post #2

If they stopped banning Astrazeneca too, and stopped vaccinating people who already had COVID, we could be done within 60 days. Astrazeneca is well above the FDAs original safety and efficacy guidance and something I'd be glad to take and give my family.

Nothing is "banned". AZ accidentally ran their first trial with only half the intended dose. For some reason, this turned out to work better than the intended regimen (90 % vs 60 % in the other trial). When they noticed the mistake, they pretended it had been their intention all along. That's one troubling error, one surprising result that doesn't fit expectations and could, therefore, indicate other, potentially dan…

And it turns out the cohort who received the half dose was on average younger than the total study population, this explaining the apparent improvement in efficacy

Re: FDA grants authorization to Moderna's Covid-19 vaccine

#29

Post by wycy »

FreakyT wrote: post #7

Glad to hear it! One key advantage of the Moderna one versus the similar Pfizer/BioNTech vaccine is that it doesn't require deep freeze storage, only regular freezing temperatures. (-90º C for Pfizer/BioNTech vs -20º C for Moderna)

Do both vaccines require 2 doses? Also, is the second dose different or just a duplicate of the first?

Re: FDA grants authorization to Moderna's Covid-19 vaccine

#30

Post by graeme »

djsumdog wrote: post #13
maxerickson wrote: post #10

Earlier quoted context omitted.

It's $40, not super expensive. 600 million doses would cost $25 billion, a trifle compared to how much the pandemic is costing.

Well hundreds of millions have already flowed into every major pharma company for development costs, so the price for tax payers in every contributing country is substantially higher than $40/person. That's just the price an individual may see.

Did you mean hundreds of billions? Hundreds of millions is a tiny amount relative to the billions of doses under production.

Hundreds of billions is not accurate either though.

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