I don't understand the controversy. We know full well the natural world is full of substances with significant impact on our bodies. Many such substances can even on average be harmful, but when used correctly, they are beneficial. Opioids come to mind first and foremost. It's not controversial to give e.g. serious accident victims a shot of morphine. Why are investigations into medicinal use of shrooms or marijuana…
Playing the devils advocate, and I think this is a pretty strong point against shrooms: while opioids cause harm, their harm is incredibly mechanical (it’s just addiction) and can be managed well. Shrooms play with your brain. We barely know how that works and quite frankly a lot of the research into managing the depressive episodes with shrooms may just be that you become more stupid and therefore less prone to thin…
Other than that, I think you are absolutely right tho, mushrooms can induce severe changes. I am not for legalization. And I believe your point is why most people under legal psychedelic treatment are terminal patients.