Didn't read this article, but saw this in another article: > Every 20 minutes, the participants were asked to remove their masks for five minutes, bringing their oxygen back to normal levels. However, during this period, researchers saw that fluctuations in the free oxygen concentration were interpreted at the cellular level as a lack of oxygen – rather than interpreting the absolute level of oxygen. > In other words…
Why would oxygen shortage lead to cell generation ? If I regularly choke myself, will I end up living longer ?
Were there any tangible benefits observed? Did the participants' heath quantifiably improve in any way? This kind of observation is missing from the article; if the expected benefits of telomere length is increased health and longevity, does the lack of such result suggest that they are less involved in aging than we think?
The main outcome of the study was to measure an in improvement in cognition: https://www.aging-us.com/article/202188/text
There doesn't seem to be any mention of cognition as a result in the article. The primary endpoint was telomere length.
Telomeres are intentionally shortened by the body, a process which is no doubt favored by evolution. While we don't know why for sure, it is entirely possible that telomere shortening actually lengthens life. As telomeres become shorter, cell division becomes slower and metabolism decreases. This means that an older person's cells will reproduce at a slower rate than a younger person's in general. If we suppose that…
My guess is that the shortening of telomeres—and the presumed aging effects—is evolutionarily beneficial because it sets an expiration date on your life. If people could live forever they may prohibit other younger and genetically different people from reproducing and introducing variety in the gene pool. Certainly having wealthier people live forever now would be bad from a social perspective. Time is really the big…
With biomedical and technological advancements, this scenario is highly likely. At some point in the future, I can envision almost a divergence in human species - those who age naturally and live similar to how we do today, and those who’s wealth has afforded them medical and technical enhancements prolonging their lives, enhancing their abilities, and allowing them to control vast amounts of resources. Perhaps they will at least keep us as beloved family pets.
Junk article. It's certainly not a "holy grail"...the study just measured telomere length after HBOT. Even meditation has been shown to reduce telomere length. It certainly didn't "reverse human aging".
HN people: please stop posting these junk newspaper articles that completely misrepresent the science.
Telomeres are intentionally shortened by the body, a process which is no doubt favored by evolution. While we don't know why for sure, it is entirely possible that telomere shortening actually lengthens life. As telomeres become shorter, cell division becomes slower and metabolism decreases. This means that an older person's cells will reproduce at a slower rate than a younger person's in general. If we suppose that…
My guess is that the shortening of telomeres—and the presumed aging effects—is evolutionarily beneficial because it sets an expiration date on your life. If people could live forever they may prohibit other younger and genetically different people from reproducing and introducing variety in the gene pool. Certainly having wealthier people live forever now would be bad from a social perspective. Time is really the big…
What may be a good mechanism for simple single-cellular, multi-cellular organisms, or even complex animals, is not necessarily a good mechanism for humans. If you’d like to argue that the omniscient deity intends humanity to die then perhaps that can be an acceptable philosophical argument. But evolution as a non-omniscient mechanism is not guaranteed to be an optimally benevolent process. There is no reason in that context to say that mortality is necessary for humanity other than negative emotions.
Didn't read this article, but saw this in another article: > Every 20 minutes, the participants were asked to remove their masks for five minutes, bringing their oxygen back to normal levels. However, during this period, researchers saw that fluctuations in the free oxygen concentration were interpreted at the cellular level as a lack of oxygen – rather than interpreting the absolute level of oxygen. > In other words…
Why would oxygen shortage lead to cell generation ? If I regularly choke myself, will I end up living longer ?
> chamber inducing a state of hypoxia, or oxygen shortage, which caused the cell regeneration. Might actually be related to life extension through calorie restriction in this regard. This paper re calories restriction mentions: > caloric restriction improves whole body energy efficiency by inducing the biogenesis of mitochondria that utilize less oxygen and produce less reactive oxygen species (ROS). https://journals…
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901353/ I thought the free radical/antioxidant stuff was done with?
The calorie restriction one says:
> increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL
Telomeres are intentionally shortened by the body, a process which is no doubt favored by evolution. While we don't know why for sure, it is entirely possible that telomere shortening actually lengthens life. As telomeres become shorter, cell division becomes slower and metabolism decreases. This means that an older person's cells will reproduce at a slower rate than a younger person's in general. If we suppose that…
My guess is that the shortening of telomeres—and the presumed aging effects—is evolutionarily beneficial because it sets an expiration date on your life. If people could live forever they may prohibit other younger and genetically different people from reproducing and introducing variety in the gene pool. Certainly having wealthier people live forever now would be bad from a social perspective. Time is really the big…
Telomeres aren’t longer because people aren’t choosing to reproduce exclusively with people who produce long telomeres.
Didn't read this article, but saw this in another article: > Every 20 minutes, the participants were asked to remove their masks for five minutes, bringing their oxygen back to normal levels. However, during this period, researchers saw that fluctuations in the free oxygen concentration were interpreted at the cellular level as a lack of oxygen – rather than interpreting the absolute level of oxygen. > In other words…
Why would oxygen shortage lead to cell generation ? If I regularly choke myself, will I end up living longer ?
Hormesis is a fairly common theme in human biology.
We seem to be at our best when under mild stressors.
Didn't read this article, but saw this in another article: > Every 20 minutes, the participants were asked to remove their masks for five minutes, bringing their oxygen back to normal levels. However, during this period, researchers saw that fluctuations in the free oxygen concentration were interpreted at the cellular level as a lack of oxygen – rather than interpreting the absolute level of oxygen. > In other words…
Why would oxygen shortage lead to cell generation ? If I regularly choke myself, will I end up living longer ?