Intermittent fasting increases hippocampal neurogenesis in mice • Hacker News Board

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#21

Post by voisin » Sat, Oct 31, 2020, 5:09 PM UTC

frisco wrote: post #3

bitxbitxbitcoin wrote: post #2

I don't know enough about neurobiology to fully understand the graphs beyond the general conclusion in the title. Could someone explain what this tells us about 16 hour vs 24 hour intermittent fasting? Is one "better" than the other?

Per the figures, it looks like 16 hours had the largest effect, even larger than 24 hour fasts. But this is mouse data and should all be taken with a huge grain of salt.

Off topic: I understand “taken with a grain of salt” is meant to express diminishment of the idea it is being associated with. By saying “huge grain of salt” which is very common, doesn’t that defeat the purpose?

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#22

Post by voisin » Sat, Oct 31, 2020, 5:09 PM UTC

chiefalchemist wrote: post #8

Can we get the title updated? This is for rodents.

Title is from the original study.

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#23

Post by ahmedfromtunis » Sat, Oct 31, 2020, 5:10 PM UTC

For anyone wondering:

> Adult hippocampal neurogenesis is a process that describes the generation of new functional DGCs from adult neural stem cells through the amplification of intermediate progenitors and neuroblasts, as well as the integration of these new neurons into the existing neural circuits.

Source: https://www.nature.com/articles/s41380-018-0036-2#:~:text=Ad....

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#24

Post by johnyzee » Sat, Oct 31, 2020, 5:12 PM UTC

Fasting prompts significant release of growth hormone, so it is not surprising that it promotes cell regeneration, but interesting to see it applied to synapses.

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#25

Post by Icedcool » Sat, Oct 31, 2020, 5:12 PM UTC

ahmedfromtunis wrote: post #23

For anyone wondering: > Adult hippocampal neurogenesis is a process that describes the generation of new functional DGCs from adult neural stem cells through the amplification of intermediate progenitors and neuroblasts, as well as the integration of these new neurons into the existing neural circuits. Source: https://www.nature.com/articles/s41380-018-0036-2#:~:text=Ad... .

Oh, well that clears that up. :)

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#26

Post by smitty1e » Sat, Oct 31, 2020, 5:14 PM UTC

I find skipping lunch and going breakfast-to-breakfast on Monday and Thursday to be a good rhythm.

Being past fifty might play into it.

I think about half the USRDA is about right for my caloric intake, though I've never consulted a nutritionist.

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#27

Post by waihtis » Sat, Oct 31, 2020, 5:21 PM UTC

ei8htyfi5e wrote: post #15

rottencupcakes wrote: post #11

Earlier quoted context omitted.

Super interested in how the mice who experienced daily 24 hr food deprivation for 3 months did in the study.

They eat once a day... so I’m sure they’re fine...

Fun fact: Mice can only survive 48 hours without food, so not eating for 24 hours is quite long for them.

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#28

Post by kitotik » Sat, Oct 31, 2020, 5:22 PM UTC

ahmedfromtunis wrote: post #23

For anyone wondering: > Adult hippocampal neurogenesis is a process that describes the generation of new functional DGCs from adult neural stem cells through the amplification of intermediate progenitors and neuroblasts, as well as the integration of these new neurons into the existing neural circuits. Source: https://www.nature.com/articles/s41380-018-0036-2#:~:text=Ad... .

:/

Anyone care to ELI5 please?

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#29

Post by pkaye » Sat, Oct 31, 2020, 5:28 PM UTC

kitotik wrote: post #28

ahmedfromtunis wrote: post #23

For anyone wondering: > Adult hippocampal neurogenesis is a process that describes the generation of new functional DGCs from adult neural stem cells through the amplification of intermediate progenitors and neuroblasts, as well as the integration of these new neurons into the existing neural circuits. Source: https://www.nature.com/articles/s41380-018-0036-2#:~:text=Ad... .

:/ Anyone care to ELI5 please?

Seems like a literal translation would be "creation of neurons in the hippocampus". And the hippocampus is associated with memory and learning.

Re: Intermittent fasting increases hippocampal neurogenesis in mice

#30

Post by epmaybe » Sat, Oct 31, 2020, 5:29 PM UTC

kitotik wrote: post #28

ahmedfromtunis wrote: post #23

For anyone wondering: > Adult hippocampal neurogenesis is a process that describes the generation of new functional DGCs from adult neural stem cells through the amplification of intermediate progenitors and neuroblasts, as well as the integration of these new neurons into the existing neural circuits. Source: https://www.nature.com/articles/s41380-018-0036-2#:~:text=Ad... .

:/ Anyone care to ELI5 please?

Fasting -> new brain cells and brain connections in a specific part of the brain. At least that’s the correlation they’re going for