The main drawback of this method if used daily would be broken USB ports.
I'm at 2 out of 4 ports dead now after 1,5 years on a $10 hub so it's not bad :) In addition, it's an iMac and the ports at the back are a nightmare to use. I taped the hub to the 'foot' of the iMac so it's much easier to use.
I don't use this mode though but PIV + PIN.