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An LSD Trip “Off-Switch” May Be Coming Soon

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Re: An LSD Trip “Off-Switch” May Be Coming Soon

#21

Post by layoutIfNeeded »

throwaway287391 wrote: post #15
wreet wrote: post #2

We already have one. Give someone having a bad trip a Xanax and they're good.

Interesting, I didn't know that. Now I wish I'd had a Xanax after my one trip which kept me awake until 4-5 am after taking acid around noon (otherwise it was an incredible day, it was just annoying not being able to sleep). Don't benzos have some pretty nasty side effects and/or dependency potential though? Maybe this drug is a bit more targeted / less risky?

Benzos are given to hundreds of millions of people every year, so they're pretty safe in my opinion. But they must not be taken for longer than a few weeks and/or in high doses! Because if you stop them cold turkey, you can die from the withdrawal effects (seizures).

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#22

Post by Nursie »

throwaway287391 wrote: post #15
wreet wrote: post #2

We already have one. Give someone having a bad trip a Xanax and they're good.

Interesting, I didn't know that. Now I wish I'd had a Xanax after my one trip which kept me awake until 4-5 am after taking acid around noon (otherwise it was an incredible day, it was just annoying not being able to sleep). Don't benzos have some pretty nasty side effects and/or dependency potential though? Maybe this drug is a bit more targeted / less risky?

Benzos can be deadly if used with opiates or alcohol, as all suppress breathing and in combination can just stop it while the person sleeps. Yes, they are quite addictive if taken recreationally or used frequently for anxiety/sleep. Withdrawal is allegedly worse than opiates and can kill through seizures if done too suddenly. Benzodiazepines are also thought to be carcinogenic to some degree. When used for sleep, benzos will affect sleep quality even though they allow you to go to sleep more easily.

That all said, I have used a few types infrequently for helping to get to sleep and found them absolutely delightful, waking up refreshed and energised (and still somewhat relaxed) the next day.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#24

Post by W4ldi »

layoutIfNeeded wrote: post #21
throwaway287391 wrote: post #15

Earlier quoted context omitted.

Interesting, I didn't know that. Now I wish I'd had a Xanax after my one trip which kept me awake until 4-5 am after taking acid around noon (otherwise it was an incredible day, it was just annoying not being able to sleep). Don't benzos have some pretty nasty side effects and/or dependency potential though? Maybe this drug is a bit more targeted / less risky?

Benzos are given to hundreds of millions of people every year, so they're pretty safe in my opinion. But they must not be taken for longer than a few weeks and/or in high doses! Because if you stop them cold turkey, you can die from the withdrawal effects (seizures).

Thing with most drugs is - we barely know which long-term/not clearly traceable side effects they have. We have these big issues like heart attacks, strokes, cancer, mental issues, gene defects - all of which don't have obvious causes but surely increased with pollution, drugs and chemicals

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#25

Post by peteretep »

throwaway287391 wrote: post #15
wreet wrote: post #2

We already have one. Give someone having a bad trip a Xanax and they're good.

Interesting, I didn't know that. Now I wish I'd had a Xanax after my one trip which kept me awake until 4-5 am after taking acid around noon (otherwise it was an incredible day, it was just annoying not being able to sleep). Don't benzos have some pretty nasty side effects and/or dependency potential though? Maybe this drug is a bit more targeted / less risky?

> and/or dependency potential though?

They absolutely have dependency potential, but you have to be regularly taking them for that to be an issue, a fact which the doctor who was merrily prescribing me them failed to mention. Kicking them was much easier for me from an addictive perspective than cigarettes, but with dramatically worse side effects.

They’re also going to make a certain percentage of the population feel incredible (or just allow them to relax/sleep when they can’t usually), so they’re also very more-ish.

In short: taking them once a quarter is unlikely to be an issue unless you already have poor impulse control and easy access to them, in which case: just don’t start.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#28

Post by fiblye »

dzhiurgis wrote: post #23
wreet wrote: post #2

We already have one. Give someone having a bad trip a Xanax and they're good.

How about alcohol? I’ve only had one third of a trip and towards the end whiskey took some of the edge off.

Yeah, I’ve found having a beer definitely takes away some anxiety/twitchiness and brings me back to reality a bit faster. But it was the same for me, towards the end of a trip. Not sure how it works for somehow rapidly being swallowed by the void.

Re: An LSD Trip “Off-Switch” May Be Coming Soon

#30

Post by QUFB »

dkmar wrote: post #20

note: i’m not a doctor or anything related. Wikipedia says “5-HT2A antagonists block the psychedelic activity of LSD”[0], so wouldn’t 5-ht2a antagonists like mirtazapine work well enough here? No idea as to how quickly the trip would be tempered, though [0]: https://en.m.wikipedia.org/wiki/Lysergic_acid_diethylamide

Yes, or at least it blocks effects if you take it pre-exposure. Risperidone, an atypical antispychotic, is also known for this. Some idiotic big pharma startup will try and milk this, rather than examining cheap existing medications. Plenty of medications block 5-HT2A, I think the important requirement here would be rapid absorption and high receptor occupancy.
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