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Project Covalence

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Re: Project Covalence

#21

Post by memexy »

curryst wrote: post #20
memexy wrote: post #9

Earlier quoted context omitted.

Yes. That's not my question. Are you saying drug trials don't cover such costs and that this is standard? Because that's the pitch the company is making and it sounds odd > We put the patient in the driver’s seat before, during, and after a trial. Because it’s not just doctors who help build a healthier future. It’s patients. And it’s time to do right by them. It sounds like they're saying, "patients are treated very…

If they did, there's always going to be a debate over whether something was caused by the trial. You get a rash and have to go see a dermatologist, was it a result of the trial or unrelated? Or more seriously, you develop cancer. Was it from the trial, or from an unrelated issue? Other people might show symptoms, but it would still take time you don't have for them to sort out whether other participants have cancer,…

So how is this company addressing all those issues?

Re: Project Covalence

#22

Post by gumby »

type0 wrote: post #8
memexy wrote: post #7

Earlier quoted context omitted.

I looked at the site > Participate in a clinical trial at no cost to you or your health insurance. Why would health insurance be involved when running medical trials and why would it cost anything? The pitch doesn't make sense to me. I always assumed medical trials were free for the participants. No idea who their target demographic is which makes me suspicious already.

> Why would health insurance be involved when running medical trials and why would it cost anything? To cover for the possible adverse effects

Actually AEs, and especially SAEs, are more often than not handled by the clinical investigators or trial sponsor, for a variety of reasons.

Insurance policies often don't cover you while you're enrolled in a trial ("you wouldn't have broken your leg if you hadn't been in that cholesterol drug trial so we don't cover that").

The agency really cares a lot, especially about SAEs, and if someone is hit by a trolley while in a cholesterol drug study they will want the company to promptly determine that the drug didn't cause them to stumble, or lose vision, or be confused about where they were. We used to joke at one company, "but being hit by a meteor is not an SAE."

Re: Project Covalence

#23

Post by hairytrog »

shoyer wrote: post #17
hairytrog wrote: post #11

It is now clear that Covid-19 is not as dangerous as was thought and hyped by media and governments worldwide, and that the prescribed shutdown cure has been and will be much worse than the disease itself. Please see ( https://swprs.org/a-swiss-doctor-on-covid-19/ ) for a pretty clear summary or follow Aaron Ginn. Covid-19 vaccine development is nearly useless at this point. That said, we need countermeasures and res…

This is actively dangerous misinformation. In places where the pandemic is not under control, there have been vast numbers of excess deaths: https://www.nytimes.com/interactive/2020/04/21/world/coronav... We are still far from the peak in most parts of the world. New York City has a population about 8 million, with 24,000 [1] excess deaths and an antibody positive rate of about 20% [2]. Do you really think it would b…

Lots of downvotes on my comment. A somewhat hilarious denial of what is plainly visible. Did you people even read the linked summary? The economy was hijacked for a complete non-threat, driven by increasingly discredited studies, "experts" speaking in apocalyptic terms, and a media looking for crisis.

Re: Project Covalence

#24

Post by chintan »

Great initiative! There needs to be more effort towards streamlining these trials.

At TrialX [1], we also launched Covid Labs Initiative to Hack The Pandemic [2] by bringing together hackers in Clinical Trials informatics space - Drop us a note hackcovid@trialx.com if interested.

We are seeing an unprecedented activity on-the-ground at various orgs[3,4,5] where we power the clinical trials recruitment. There is a huge interest in patient/volunteer community. Any effort to streamline and accelerate would be welcome.

1. https://trialx.com

2. https://trialx.com/covid-labs/

3. https://www.pennmedicine.org/coronavirus/covid-19-clinical-t...

4. https://www.centerwatch.com/covid-19-treatment-information

5. https://clinicaltrials.med.nyu.edu/clinicaltrials/?keyword=C...

Re: Project Covalence

#25

Post by jessfyi »

jxramos wrote: post #5

I've actually been wondering as covid19 winds down and people's lived experiences no longer perceive it as the doom and gloom threat it once held sway with, if given that perception whether the market rewards will continue to stand and attract massive investments in pursuit of a vaccine where the rewards may not outweigh the risks. I would think that would be a pretty strong signal that covid is not as large a risk i…

If you're in America, covid19 is not winding down. After working for Roche I think statements and projects like this are here solely for lip-service/to quickly attract VC bucks, but the threat is still very real and every major pharma company is dedicating resources and or M&A teams to the vaccine effort.

Re: Project Covalence

#26

Post by simonebrunozzi »

hairytrog wrote: post #23
shoyer wrote: post #17

Earlier quoted context omitted.

This is actively dangerous misinformation. In places where the pandemic is not under control, there have been vast numbers of excess deaths: https://www.nytimes.com/interactive/2020/04/21/world/coronav... We are still far from the peak in most parts of the world. New York City has a population about 8 million, with 24,000 [1] excess deaths and an antibody positive rate of about 20% [2]. Do you really think it would b…

Lots of downvotes on my comment. A somewhat hilarious denial of what is plainly visible. Did you people even read the linked summary? The economy was hijacked for a complete non-threat, driven by increasingly discredited studies, "experts" speaking in apocalyptic terms, and a media looking for crisis.

> The economy was hijacked

So, a conspiracy? I bet hundreds of people met in secret at least once in the past few months, and decided it would have been really lucrative to stage this farce. Well played! And nobody will ever know.

Sarcasm or jokes apart... Who, tell me who would have had the power and the drive to set this up?

Re: Project Covalence

#27

Post by jxramos »

cinntaile wrote: post #19
jxramos wrote: post #5

I've actually been wondering as covid19 winds down and people's lived experiences no longer perceive it as the doom and gloom threat it once held sway with, if given that perception whether the market rewards will continue to stand and attract massive investments in pursuit of a vaccine where the rewards may not outweigh the risks. I would think that would be a pretty strong signal that covid is not as large a risk i…

Most of the big pharma companies are developing a vaccine. [0] The ones that aren't specifically mentioned by name are probably funding some of the smaller biotech companies instead. [0] https://en.wikipedia.org/wiki/COVID-19_vaccine

That is an exceedingly thorough wiki article. What a great testament to community efforts. Thanks for sharing.

Re: Project Covalence

#28

Post by redis_mlc »

jxramos wrote: post #5

I've actually been wondering as covid19 winds down and people's lived experiences no longer perceive it as the doom and gloom threat it once held sway with, if given that perception whether the market rewards will continue to stand and attract massive investments in pursuit of a vaccine where the rewards may not outweigh the risks. I would think that would be a pretty strong signal that covid is not as large a risk i…

As soon as SARS-1 died down in 2003, all human vaccine efforts and trials stopped.

Even worse, funding for general corona virus research also was not available.

That's why even though SARS-1 was in 2003, we're nowhere with SARS-2.

(China hid SARS-1 from about Nov. 2002 to Jan. 2003, similar to SARS-2.)

Re: Project Covalence

#29

Post by redis_mlc »

simonebrunozzi wrote: post #26
hairytrog wrote: post #23

Earlier quoted context omitted.

Lots of downvotes on my comment. A somewhat hilarious denial of what is plainly visible. Did you people even read the linked summary? The economy was hijacked for a complete non-threat, driven by increasingly discredited studies, "experts" speaking in apocalyptic terms, and a media looking for crisis.

> The economy was hijacked So, a conspiracy? I bet hundreds of people met in secret at least once in the past few months, and decided it would have been really lucrative to stage this farce. Well played! And nobody will ever know. Sarcasm or jokes apart... Who, tell me who would have had the power and the drive to set this up?

There have multiple conspiracies with covid-19:

- coverup at Wuhan Corona Lab in Dec. and disappearance of local doctors

- coverup of US government funding and oversight of that lab

- California has had flat hospital stats for 3 months, yet we're still lockdown because Gavin Newsom wants to be President

Re: Project Covalence

#30

Post by redis_mlc »

nostromo wrote: post #15
hairytrog wrote: post #11

It is now clear that Covid-19 is not as dangerous as was thought and hyped by media and governments worldwide, and that the prescribed shutdown cure has been and will be much worse than the disease itself. Please see ( https://swprs.org/a-swiss-doctor-on-covid-19/ ) for a pretty clear summary or follow Aaron Ginn. Covid-19 vaccine development is nearly useless at this point. That said, we need countermeasures and res…

Just today I was reading that vaccinations in many countries were stopped to prevent Covid-19 transmission, and now children are starting to die. https://www.nytimes.com/2020/06/14/health/coronavirus-vaccin...

There will be so much collateral damage due to the lockdown.

- wiped out most small business owners (anybody who rents a store front, etc.

- delayed chemotherapy treatments

- delayed coronary checkups and treatment.

- doctors are reporting high rates of suicides

There will probably be more collateral than corona deaths in the US, especially when you factor in co-morbidity.

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