As a music student, I was always amazed at the irony of Schoenberg's thesis about the "Liberation of the Dissonance", when 12 tone Equal Temperament is an arbitrary intonation system that limits the actual potential for freedom when creating harmony. Ben Johnston, an American composer who studied with Harry Partch, used extended Just Intonation, which is a system of unlimited harmonic capabilities, for several serial…
"And above all; this scale is not the last word, the ultimate goal of music, but rather a provisional stopping place. ... Whether there will then be quarter tones, eighth, third, or (as Busoni thinks) sixth tones, or whether we will move directly to a 53-tone scale that Dr. Robert Neumann has calculated, we cannot foretell. Perhaps this new division of the octave will even be untempered and will not have much left over in common with our scale. ... Probably, whenever the ear and imagination have matured enough for such music, the scale and the instruments will all at once be available."
I'd say that last prediction was very prescient!