I'd be curious to see a more thorough comparison to S2, which IMHO seems simpler (it's just quadtrees) and likely faster (it supports O(1) lookup vs. needing a hierarchical search).
Representation systems for geospatial data models is an amazingly deep theoretical rabbit hole. Common systems are almost always optimized for presentation as most were originally designed for cartographic use cases. If you were looking at representation systems optimized for fast, scalable geospatial analytics, for example, you'd use some type of 3-space embedding representation. There is a lot of diversity.