21–30 of 34 posts
How and if people got autism before processed foods?
The article notes the link between certain kinds of bacteria in ASD children that overproduce PPA as a byproduct.
Or maybe the "rise" in autism rates is due to the fact that our diagnostic tools have become more advanced in the past 20 years which has resulted in more people getting their diagnoses. In particular older people (i.e. 30+) are getting diagnosed just now because doctors previously didn't know what they were looking for.
Or maybe the "rise" in autism rates is due to the fact that our diagnostic tools have become more advanced in the past 20 years which has resulted in more people getting their diagnoses. In particular older people (i.e. 30+) are getting diagnosed just now because doctors previously didn't know what they were looking for.
Earlier quoted context omitted.
Were the "high levels" of PPA food level, or 100x total human lifetime exposure? This is very preliminary speculative science that shouldn't be oversold.
The elevated levels of PPA are linked to a dysbiotic gut bacteria imbalance, with ASD children exhibiting more bacteria that produce PPA. I'd imagine if you're not eating PPA in excess of your body's ability to metabolize it you're fine. Regarding the second half of your comment, I'll cite from the etiology article I linked: > In the concluding sentences of their analysis, Witters and Debold make their strongest argu…
> Research produced in 2016 by Drs Peter Witters and Eric Debold corroborates the link between the two conditions in a longitudinal study of 12 patients investigating blood metabolite balance in patients with PA and behavioral disruptions.
From https://en.wikipedia.org/wiki/Propionic_acidemia the incidence of PA is 1/3500 and from https://en.wikipedia.org/wiki/Autism_spectrum the incidence of ASD is 1/100, so assuming independence it's expected that you can find in the word 7000000000/3500/100 = 20000 person with both illness, and they are analyzing a group of 12 patients with PA and only 5 have clear ASD and other 3 have only some symptoms of ASD.
Even if this isn't rock-solid I'd rather see a backlash against processed foods than against vaccines.
This is why I quit diet soda. I don't really want to drink some science experiment.
http://lateralscience.blogspot.com/2017/12/the-radium-water-...
Even if this isn't rock-solid I'd rather see a backlash against processed foods than against vaccines.
Thinking about this a lot lately. Biggest thing is getting people ready to put in the time needed to process food themselves. Reducing packaging and eating better food takes A LOT of time, and I don't think anyone except the portion of us that like to hunt recipes and cook are ready for that.
And I suppose if you don't know how to turn on the oven then the whole endeavor looks like marathon running (and winning) looks to a bed-ridden person. But your goal is not to be a professional chief in 5 star restaurant, it is to cook some soup from whatever is in the fridge, boil some pasta, fry some eggs and chop up some greens. Cook enough to last a week and you are set.
Ask your first generation immigrant coworker to teach you what they cook (or ask them to introduce you to their parents :)).
Earlier quoted context omitted.
The elevated levels of PPA are linked to a dysbiotic gut bacteria imbalance, with ASD children exhibiting more bacteria that produce PPA. I'd imagine if you're not eating PPA in excess of your body's ability to metabolize it you're fine. Regarding the second half of your comment, I'll cite from the etiology article I linked: > In the concluding sentences of their analysis, Witters and Debold make their strongest argu…
How did they make the calculation? From the same article: > Research produced in 2016 by Drs Peter Witters and Eric Debold corroborates the link between the two conditions in a longitudinal study of 12 patients investigating blood metabolite balance in patients with PA and behavioral disruptions. From https://en.wikipedia.org/wiki/Propionic_acidemia the incidence of PA is 1/3500 and from https://en.wikipedia.org/wiki…
> With the increasing reported frequency of ASD in the pedi-atric population one cannot rule out a possible coincidence of the diagnosis of ASD in patients with propionic acidemia.
Regarding the calculation, Wikipedia says 1 in 35000 for PA the US, rather than 3500, and the researchers use an incidence rate of .5% for autism rather than 1%. So the number of people is 1000, not 20000. The researchers say they're calculating off a 5/8 ASD/PA incidence rate, so the calculation is something like (1000/7 billion)^5*(some negligible amount)^3.
Or maybe the "rise" in autism rates is due to the fact that our diagnostic tools have become more advanced in the past 20 years which has resulted in more people getting their diagnoses. In particular older people (i.e. 30+) are getting diagnosed just now because doctors previously didn't know what they were looking for.
Do you not think that the highly competent researchers didn't account for this very well know the rise in the data. Their findings here are novel, critically important and are related to a host of other works revealing the intricate links between the gut biome and neurobiology previously unknown. Parkinsons is another disease that recently has been shown to potentially be related to changes in the gut biome.
Earlier quoted context omitted.
How did they make the calculation? From the same article: > Research produced in 2016 by Drs Peter Witters and Eric Debold corroborates the link between the two conditions in a longitudinal study of 12 patients investigating blood metabolite balance in patients with PA and behavioral disruptions. From https://en.wikipedia.org/wiki/Propionic_acidemia the incidence of PA is 1/3500 and from https://en.wikipedia.org/wiki…
You're right that it's a low sample size, and the authors themselves do warn that diagnostic rates of ASD in children may be inflated: > With the increasing reported frequency of ASD in the pedi-atric population one cannot rule out a possible coincidence of the diagnosis of ASD in patients with propionic acidemia. Regarding the calculation, Wikipedia says 1 in 35000 for PA the US, rather than 3500, and the researcher…
OK. I'm fine with that. My idea was to show that if we assume independence, it is not difficult that someone can find 12 cases with both illness.
* About the calculation:
Is that in the paper? [I assume that "some negligible amount" means "close to 1".]
This calculation is the probability that if you pick 12 persons at random from the whole word population you find a group with 5 person with PA+ASD and 3 PA+dubiousASD and 4 with PA+noASD. There is a missing (1-epsilon)^4 that doesn't matter. And you need to add some combinatorial number, like (12! / 5! 3! 4!) ~= 30000.
Even assuming that "1-epsilon" and "some negligible amount" are equal to 1, the result of your calculation is 6E-35 that is much much much smaller than the reported result 4E-13 (after using the combinatorial number you get or 2E-30 that is still smaller). So they clearly used another calculation.
Anyway, your calculation is wrong because you can't use the probabilities of the general population in a calculation of a group that you cherrypicked.
Earlier quoted context omitted.
Thinking about this a lot lately. Biggest thing is getting people ready to put in the time needed to process food themselves. Reducing packaging and eating better food takes A LOT of time, and I don't think anyone except the portion of us that like to hunt recipes and cook are ready for that.
Basic cooking taking a lot of time is a myth. Sure, if you don't have a kitchen and a fridge at all, that is a problem. And I suppose if you don't know how to turn on the oven then the whole endeavor looks like marathon running (and winning) looks to a bed-ridden person. But your goal is not to be a professional chief in 5 star restaurant, it is to cook some soup from whatever is in the fridge, boil some pasta, fry s…
Compare a fresh head of broccoli to a package frozen; with fresh, you've got to clean it, trim it, clean up after your trimming, and finally cook it. With frozen, snip a bag open and you're on your way. Much simpler, but of course now you're using something that was shipped from afar, wrapped in plastic, and held in a freezer and it won't even taste as good when you're done!
Now compare ordering delivery from your phone. Compare shopping, storing, chopping, wiping up etc. to building a Blue Apron dinner. In terms of convenience, it's not even close. This is coming form someone who prepares 2-3 meals per day for my family.