Inhalable insulin was a total failure, even though it worked. I don't expect this to succeed where inhalable insulin failed.
New pill can deliver insulin
21–30 of 260 posts
Re: New pill can deliver insulin
#22> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…
What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…
T1 here. This is a perfect summary. I received my Dexcom G6 yesterday. If you dont have a CGM and insulin pump, I highly recommend both.
Re: New pill can deliver insulin
#23Earlier quoted context omitted.
What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…
T1 here. This is a perfect summary. I received my Dexcom G6 yesterday. If you dont have a CGM and insulin pump, I highly recommend both.
One thing I'm worried about WRT switching to a pump is the impact of heat on insulin. I can't have a Humalog pen exposed to 80+ degree heat for more than a few minutes without it losing efficacy. I live in Texas. What will stop the summer heat from cooking all the insulin in my pump's reservoir while I'm walking down the street?
Do you have any thoughts on this? I'd love to have more flexibility.
Re: New pill can deliver insulin
#24Study by Novo Nordisk. one of the fine companies responsible for raising insulin prices by thousands of percent.
Jesus man. Novo has invented and produced more insulin in the last 30 years than any other company or organization. I get that you're disgruntled about the price of insulin; I am, too. But put the blame where it belongs, not on the people who are producing more and more insulin to accommodate more and more diabetic lifestyles and helping to drive the price down rather than up.
Per a quick google <15% of type 2 diabetics use insulin. I would say this effects more type 1 diabetics than anything. Or are you trying to say peoples lifestyles are leading them to an autoimmune disease?
Re: New pill can deliver insulin
#25> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…
What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…
Vegetables & fruits are the ultimate medicine for all disease.
Have you seen elephants having such diseases?
Re: New pill can deliver insulin
#26> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…
What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…
> I don't know a single diabetic who cares about injections and blood sugar tests.
I'm diabetic and the sole reason I don't check my blood sugar (unless I think something is drastically out of whack) is that it takes me upwards of 30 minutes to do a finger prick for testing. My anxiety skyrockets and nothing I do can tell me that it's not going to be excruciating. Most of the time I end up having my wife do it, which isn't a fun process for either of us.
It's not the worst thing, but it's deeply, deeply unpleasant for me. Come at me with a 10ga needle, I won't flinch; come at me with a 30ga lancet and I'll be a mess. I'm going to be switching to a CGM purely for this reason.
Re: New pill can deliver insulin
#27Study by Novo Nordisk. one of the fine companies responsible for raising insulin prices by thousands of percent.
Jesus man. Novo has invented and produced more insulin in the last 30 years than any other company or organization. I get that you're disgruntled about the price of insulin; I am, too. But put the blame where it belongs, not on the people who are producing more and more insulin to accommodate more and more diabetic lifestyles and helping to drive the price down rather than up.
Novo Nordisk has yearly profits of somewhere in the neighborhood of 10b a year.
Those numbers are partially generated by pricing insulin products out of reach of many people who died from not being able to afford it.
Sorry if I don't have a lot of sympathy for them.
Re: New pill can deliver insulin
#28Earlier quoted context omitted.
Jesus man. Novo has invented and produced more insulin in the last 30 years than any other company or organization. I get that you're disgruntled about the price of insulin; I am, too. But put the blame where it belongs, not on the people who are producing more and more insulin to accommodate more and more diabetic lifestyles and helping to drive the price down rather than up.
Per a quick google <15% of type 2 diabetics use insulin. I would say this effects more type 1 diabetics than anything. Or are you trying to say peoples lifestyles are leading them to an autoimmune disease?
I'm saying Novo Nordisk produces insulin, and in doing so causes downward pressure on insulin prices thanks to basic economics. (When the supply of a good increases at the same level of demand, price falls.) This is true for both type 1 and type 2 diabetics.
In Novo's case, they have two kinds of long-acting insulin analogue taken 1-2 times per day for both T1 and T2; they have to my knowledge the only ultra-long-acting insulin on the market, taken once every 2-3 days, most appropriate for T2, but also viable for some T1 lifestyles; they have very-rapid-acting insulin for T1 diabetics only, and they have older kinds of insulins appropriate for older patients.
They offer all of these products in good supplies. I've never seen or heard of a Novo product's being unavailable at the pharmacy. So, as far as I can tell, their only influence on insulin prices is downward pressure, not upward pressure. Every new product they produce lowers the price of insulin despite industry-wide changes.
Re: New pill can deliver insulin
#29> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…
Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract.
With the right compound in the needle, thst sounds like an incredible way to assassinate someone without leaving any traces which are unlikely to be found. The combination of a tiny needle mark on the inside of the stomach, a lack of dissolved pills in the gut, and a likely delay between administration and onset of effects, it’s sort of perfect.
Re: New pill can deliver insulin
#30What's the point of having this be an internal device? Why not use the same technology to make external injection devices easier to use? It seems to me like having the device be internal just increases the number of possible failure modes and makes failures harder to spot/recover from.