Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Ibuprofen alters human testicular physiology to produce compensated hypogonadism

ncbi.nlm.nih.gov

Post reply on HN
Print view View original

21–30 of 251 posts

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#21

Post by tbabb »

wmccullough wrote: post #7

As someone who is XXY, I can’t help but wonder what, if any issues would be caused by a pregnant mother taking a lot of this.

This seems like an endocrine effect, rather than a chromosomal one.

I'd expect XXY to cause endocrine effects because sex-linked cells are operating with bad genetic info.

This paper suggests that Ibprofen might cause sex-linked cells to misbehave because of chemistry.

It doesn't seem like there is evidence here that Ibprofen would have had an effect on chromosomes. These are two independent causes of sex-linked malformity/endocrine issues, not a case of one causing the other.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#22

Post by eaandkw »

Alex3917 wrote: post #5

600mg per day is an enormous dose, albeit not especially uncommon. I’d be more interested though in the effects of, say, 200 - 400mg per week.

Clearly you have never been in the USMC. In hind sight it was pretty stupid but I have taken up to 1600mg per day for several days/ weeks in a row.

We pretty much call the 800mg tablets grunt candy.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#24

Post by mhd »

azhenley wrote: post #10
Alex3917 wrote: post #5

600mg per day is an enormous dose, albeit not especially uncommon. I’d be more interested though in the effects of, say, 200 - 400mg per week.

It isn’t enormous at all. 400mg every 4 hours is the OTC dose (at least in the US). My prescription was 800mg.

That's the local OTC dose here (Germany), too, although I always got the somewhat strict advise that this shouldn't be kept up for more than four days in a row.

Mostly because of renal damage and gastrointestinal issues, if I remember correctly.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#25

Post by lbotos »

couradical wrote: post #14
Alex3917 wrote: post #5

600mg per day is an enormous dose, albeit not especially uncommon. I’d be more interested though in the effects of, say, 200 - 400mg per week.

How is that an enormous dose? The recommendation is 2x200mg every 4-6h. When doing competitive athletics, I probably took 1-3g of “vitamin I” a day. 600mg a day is barely above a single dose.

What were you taking it for? Pain reduction? (Curious, no judgement, trying to understand if there was any other reason)

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#26

Post by CptFribble »

azhenley wrote: post #4

This is terrifying. I used to take a lot of ibuprofen for frequent headaches (much better now). Military doctors were overzealous with the 800mg prescriptions (double the OTC dose). I suppose I should just use naproxen or acetaminophen? Ibuprofen always seemed the most effective to me.

The paper mentions that at issue are all NSAIDs, including aspirin, etc.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#27

Post by wenc »

Alex3917 wrote: post #5

600mg per day is an enormous dose, albeit not especially uncommon. I’d be more interested though in the effects of, say, 200 - 400mg per week.

I'm not sure if it counts as enormous. I'm looking at my Ibuprofen bottle and it says do not exceed 6 (200mg) tablets in 24 hours unless directed by doctor, so 1200 mg is the OTC maximum recommended dose per day.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#28

Post by Dylan16807 »

Alex3917 wrote: post #20
azhenley wrote: post #10

Earlier quoted context omitted.

It isn’t enormous at all. 400mg every 4 hours is the OTC dose (at least in the US). My prescription was 800mg.

> My prescription was 800mg. Sure, but it’s not like 800mg is 4x or even 2x more effective than 200mg. Ibuprofen is great, I just don’t really see the point of risking dying and whatever else for what’s at most a very marginal benefit. It’s not enormous in the sense that it’s uncommon per se, but rather in the sense that it’s way outside the efficient frontier on the risk/reward curve.

> I just don’t really see the point of risking dying and whatever else

Ibuprofen is not the painkiller where taking 2x the recommended limit has an enormous risk of death.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#30

Post by sawhit »

lelandgaunt wrote: post #15
wmccullough wrote: post #7

As someone who is XXY, I can’t help but wonder what, if any issues would be caused by a pregnant mother taking a lot of this.

Long term acetaminophen usage is linked to a reduction in empathy.[0] [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015806/

As far as I can tell, the article linked says that there was a reduction in empathy (for pain) directly after being administered acetaminophen. I'm not seeing anything about long term use.
Post reply on HN