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The Link Between Inflammation and Depression?

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Re: The Link Between Inflammation and Depression?

#21

Post by finaliteration »

InGodsName wrote: post #12
finaliteration wrote: post #5

Earlier quoted context omitted.

I think a larger problem is that it’s such a crapshoot about which treatments will work for a given individual, pharmaceutical or not. It took me about 10 therapists with varying backgrounds before I finally found one that would help. It also took me trying several different medications to find a combination that’s actually effective. It’s a lot of work and effort, and most people suffering through depression, anxiet…

what worked in your case?

I suffer from PTSD due to childhood trauma which is ultimately the cause of my anxiety, depression, mood swings, etc,. Right now I’m seeing a therapist who specializes in trauma and going through EMDR (eye movement desensitization and reprocessing) treatment. I’ve also taken Wellbutrin (anti-depressant) and Lamictal (mood stabilizer) for the last 18 months or so.

I also just have to constantly keep busy. I fill my time with work and activities with my family. I rarely take downtime because if I do the dread and flashbacks rear their ugly heads.

Re: The Link Between Inflammation and Depression?

#22

Post by z3t4 »

InGodsName wrote: post #14

We don't know about severity of the depression when we say depression. My friend has racing thoughts, feeling tired all time, unable to move, unable to think. Negatives thoughts amplifying to point where nothing no longer makes sense. Can such depression be treated? When she was born, she had a serological conflict. 1. She first recognized it at age 8. 2. Now she's 18 3. Tried sucide at 16 It's not like she doesn't w…

i think its warranted to go see a doctor.

Re: The Link Between Inflammation and Depression?

#23

Post by denerio-a »

atomical wrote: post #13
astazangasta wrote: post #9

Earlier quoted context omitted.

Most medications DON'T work for most people. For example here[1] is a meta-analysis from 2004 of the top 6 antidepressants which finds that 80% of the effect is achieved by placebo, and the remaining effect is statistically, but not clinically, significant (that is, the effect size is tiny). Here[2] is another follow-up that shows that there may be effects only in the most severely-depressed patients. In addition the…

Do none of your friends have severe depression? CBT doesn't work for severe depression without medication in my experience.

That seems a strange reply to a comment that acknowledged medication only really has a real effect in severe cases.

Even for a friend who is severely depressed, which medication will work? How long does each one need to be tried for? What is meant by ‘work’ exactly? Meanwhile, the serious side effects aren’t even fully understood, and you’ll be buying them from companies that actively denied and hid such information from legislators and the public.

Re: The Link Between Inflammation and Depression?

#24

Post by Bucephalus355 »

This is very important. It’s not yet fully understood, but something is missing yet in our understanding of inflammation.

It’s not everything, just like antibiotics weren’t everything, but progress here will mean curing an incredible amount of human suffering.

The book linked below, a late 2015 text on Molecular Neuropharmacology, is fascinating. Every chapter has a mention of inflammation and usually ibuprofen. It’s that important.

Particularly fascinating is the connection with ADHD, Parkinson’s, and Schizophrenia. All of the diseases have something to do with dysregulation of Dopamine. In particular, it seems like Ibuprofen helps with reducing the effects of Dopamine overload, which is essentially what Schizophrenia is. It’s an inflammation of the mind that is somewhat similar to how we now think sugar causes harm/inflammation. Anyway this overload eventually can lead to underload, or Parkinson’s. ADHD individuals are often overloaded as well due to the treatment with stimulant medication (which is good but can be abused).

I’m not kidding when I say there are Nobel prizes being left on the table here right now.

https://www.amazon.com/Molecular-Neuropharmacology-Foundatio...

Re: The Link Between Inflammation and Depression?

#25

Post by fromthestart »

jganetsk wrote: post #11
mettamage wrote: post #10

Earlier quoted context omitted.

Would anyone have an idea why this could potentially be?

https://www.mdedge.com/fedprac/article/81232/mental-health/n...

I'd caution anyone making a link between depression and NSAIDs from that paper. Most of those people probably climbed out of depression because they specifically administered pain medication to subjects with osteoarthritis. Suddenly being rid of chronic pain can be liberating.

Re: The Link Between Inflammation and Depression?

#26

Post by auganov »

Bucephalus355 wrote: post #24

This is very important. It’s not yet fully understood, but something is missing yet in our understanding of inflammation. It’s not everything, just like antibiotics weren’t everything, but progress here will mean curing an incredible amount of human suffering. The book linked below, a late 2015 text on Molecular Neuropharmacology, is fascinating. Every chapter has a mention of inflammation and usually ibuprofen. It’s…

Interesting definitely adding this to my reading list for self serving reasons. I independently came to similar ideas about inflammation, mostly because I have to take a lot of Ibuprofen for chronic pain and what works best is taking some preemptively on non painful days. That is, I always tried to think up more reasons for why this isn't a terrible idea.

Re: The Link Between Inflammation and Depression?

#27

Post by ada1981 »

I suffered from suicidal depression, anxiety, mania, psychosis, paranoia, panic attacks and more.

I flirted with diagnosis of schizoaffective disorder to bipolar.

My life was pretty out of control.

I didn’t like the outcomes I saw of people who were on meds their entire life and I didn’t buy the story from mainstream psychiatry.

I found MDMA therapy via an underground practice and it transformed my life over the course of a few session.

I was able to get to the root of all symptoms and heal what was beneath.

Combined with Holotropic Breathwork and NARM / somatic therapy for integration, this approach blew anything the psychiatrists were offering out of the water.

I’ve been experimenting with CBD and it seems to offer and even deeper level of clarity and non-anxiety.

No psychiatric meds, no symptoms and my creative and romantic life now has something to grown from - before this everything was in a constant cycle of boom and bust.

Re: The Link Between Inflammation and Depression?

#28

Post by cortesoft »

ada1981 wrote: post #27

I suffered from suicidal depression, anxiety, mania, psychosis, paranoia, panic attacks and more. I flirted with diagnosis of schizoaffective disorder to bipolar. My life was pretty out of control. I didn’t like the outcomes I saw of people who were on meds their entire life and I didn’t buy the story from mainstream psychiatry. I found MDMA therapy via an underground practice and it transformed my life over the cour…

I am very glad this worked for you, but isn't MDMA a psychiatric med?

Re: The Link Between Inflammation and Depression?

#29

Post by andyidsinga »

so serendipitous - the other day ago I was putting down some wood flooring in my house and hurt my back a little - something that happens from time to time in exactly the same place - so I knew that I should get on top of it and take a couple of ibuprofen.

So I take a the ibuprofen, and take a break for an a couple hours - and as I noticed the back pain go away - I also noticed a distinct improvement in my mood! I had the exact reaction described in the article "of course, your back doesn't hurt ..duh".

The article makes me wonder if there is another explanation for the mood improvement ..

Re: The Link Between Inflammation and Depression?

#30

Post by egypturnash »

cortesoft wrote: post #28
ada1981 wrote: post #27

I suffered from suicidal depression, anxiety, mania, psychosis, paranoia, panic attacks and more. I flirted with diagnosis of schizoaffective disorder to bipolar. My life was pretty out of control. I didn’t like the outcomes I saw of people who were on meds their entire life and I didn’t buy the story from mainstream psychiatry. I found MDMA therapy via an underground practice and it transformed my life over the cour…

I am very glad this worked for you, but isn't MDMA a psychiatric med?

It started as one but after it found broad use as a recreational drug it was made illegal. It's Schedule I in the US and illegal in most countries (source: wikipedia).

Which is a shame because holy crap the one time I had MDMA sure broke me out of a major depression I'd been in for a couple decades.

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