Could a genetic algorithm have come up with this design? (Electronics seems an interesting application area for automated design, since the search space is relatively small)
I modern chip design, simulated annealing is used for placement of parts to minimize the length of routes and optimize parasitic effects.
The constraints for generic digital logic soup are comparatively "simple" : make wires as short and neat as possible and then check the (simulated) physical timing characteristics.
Analog is more artistic since any noise or crosstalk degrades the signal irreversibly (for low noise stuff) and any wire is a transmission line (for high speed stuff).
Actually even for digital I'm sure you still have to do manual layout for the most critical pieces of high-performance designs (say a register file on a nvidia gpu).