Related to this type of animation, there is a great book called "The Machinery of Life" that talks abut molecular level biology with amazing illustrations. https://www.amazon.com/Machinery-Life-David-S-Goodsell/dp/03...
The life cycle of HIV in 3D [video]
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Re: The life cycle of HIV in 3D [video]
#22Living in 2018 is quite a privilege. Most microbiologists who spent their lives trying to puzzle this out won't get to sit back and watch the answer.
Re: The life cycle of HIV in 3D [video]
#23Here's the video on vimeo https://vimeo.com/260291607
Re: The life cycle of HIV in 3D [video]
#24Earlier quoted context omitted.
One major issue is the fact that reverse transcriptase, which copies the HIV genome inside the cell, is sloppy and makes lots of mistakes. As a consequence, every viral particle produced is a little different. A drug that targets any given HIV protein to disrupt it, will work on most particles, but there’s always some that carry mutations that allow them to escape. The solution is to treat with multiple orthogonal dr…
I would think that once you kill all infected T-cells, yo got rid of all infection?
I doubt a body can completely rid itself of HIV but once you get rid of all infected T-cells you've Acquired Immune Deficiency Syndrome.
Re: The life cycle of HIV in 3D [video]
#25I think articles like Ken Shirriff's "Cells are very fast and crowded places"[1] are good companions for visualizations like this. It helps to keep in mind that the things moving around in cells are flying around at break-neck speeds if you scale them up linearly. 1 - http://www.righto.com/2011/07/cells-are-very-fast-and-crowde...
This is a really great share! Truly mindblowing.
Re: The life cycle of HIV in 3D [video]
#26Hard to believe that no one has programmed this. Evolution is insane.
Re: The life cycle of HIV in 3D [video]
#27Question. How is that even knowing the lifecycle of HIV at this level of detail, there is not a cure for it?
Ha, my thoughts were similar to yours but in the opposite direction: With such complicated machinery being involved in every part of micro biology, how can humans ever hope to cure anything? Everything down there is so complex, fast and intricate and we're stuck up here able to interact with it only in the most brute force and imprecise ways.
Re: The life cycle of HIV in 3D [video]
#28I would love to know how this animation was made. Is there any sort of simulation happening?
Yes, that was my first thought as well. I'm curious what parts are accurate and what parts are simplifications for ease of visualization and comprehension. Colors are clearly not representative. What about movements? Relative speed of movements? Shapes? Density? If we could see these processes in some magical microscope would this look close to what is happening or not?
Re: The life cycle of HIV in 3D [video]
#29I would love to know how this animation was made. Is there any sort of simulation happening?
Drew Berry creates similar animations and refers to them (in this talk) as "accurate representations", but doesn't go into much detail. Interesting history in the beginning as well. https://www.youtube.com/watch?v=WFCvkkDSfIU
Re: The life cycle of HIV in 3D [video]
#30Amazing! So there is self-replicating, self-modifying code (HIV quickly mutates to avoid detection) code, that sometimes jumps into middle of an instruction (GAG proteins being cut into the enveloping proteins).