Is this a permanent effect, or does T production return to normal after stopping the drug?
Ibuprofen alters human testicular physiology including testosterone production
21–30 of 67 posts
Re: Ibuprofen alters human testicular physiology including testosterone production
#22While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time
I've been prescribed that sort of dosage to deal with inflammatory issues. From limited personal experience, larger does are not about pain relief, but bringing inflammation (eg bursitis) under control.
I've been through similar doses as well, though for muscular strain I was given something stronger (not opioids though)
Re: Ibuprofen alters human testicular physiology including testosterone production
#23I've been paying attention to the lowering fertility rate across the world. My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disruptor. It didn't totally fit though so I felt like there was something else that was a major contributor. Ibuprofen being a cause of lower sperm counts could be the missing piece of the puzzle. It's also a big deal becau…
Funny to see this now, as I was thinking a little while ago of the break-in period for a new mattress I owned, where I dealt with a sore throat or asthma-like condition for a week before realizing the probable cause, after doing some reading about many with similar problems. (I closed off the bedroom with the windows open during that winter period and slept elsewhere for a little while after that.)
To me it's emblematic of the Safety State: a (relative) few die from mattress fires, so now everybody is gassed with possible or probable toxins in hyper-response.
PSA: Careful of those new mattresses…
Re: Ibuprofen alters human testicular physiology including testosterone production
#24This isn't really huge news, technically speaking. Any anti-inflammatory drug will have negative net impact on your body function. For a while we know now that NSAIDs alter ROS levels in response to injury and in fact any normal process. NSAIDs also have negative impact on training adaptation or cell death due to overexpression of ROS. So no - taking overabundant levels of oral NSAIDs isn't going to be good for you and that's why topical NSAIDs make sense in cases of joint pain, tough they're not as convenient.
Note: I remember taurine had protective effect on testicular function in men treated in 19-nor derivatives. Maybe worth checking out if it does so also for ibuprofen :)
Re: Ibuprofen alters human testicular physiology including testosterone production
#25I've been paying attention to the lowering fertility rate across the world. My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disruptor. It didn't totally fit though so I felt like there was something else that was a major contributor. Ibuprofen being a cause of lower sperm counts could be the missing piece of the puzzle. It's also a big deal becau…
At least in Italy, children are almost exclusively given paracetamol (Tylenol) to lower temperature. Ibuprofen is only used as an anti-inflammatory drug, for example if they have faryngitis
Paracetamol comes with its own set of problems. It's somewhat dangerous to people with a variety of liver conditions.
Re: Ibuprofen alters human testicular physiology including testosterone production
#26Earlier quoted context omitted.
At least in Italy, children are almost exclusively given paracetamol (Tylenol) to lower temperature. Ibuprofen is only used as an anti-inflammatory drug, for example if they have faryngitis
Paracetamol comes with its own set of problems. It's somewhat dangerous to people with a variety of liver conditions.
In large enough doses it is dangerous to everyone. The problem is that the large enough dose is much smaller than other OTC drugs.
Re: Ibuprofen alters human testicular physiology including testosterone production
#27I've been paying attention to the lowering fertility rate across the world. My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disruptor. It didn't totally fit though so I felt like there was something else that was a major contributor. Ibuprofen being a cause of lower sperm counts could be the missing piece of the puzzle. It's also a big deal becau…
My money would be on increasing levels of education and healthcare instead of fire retardant chemicals and ibuprofen.
Re: Ibuprofen alters human testicular physiology including testosterone production
#28Re: Ibuprofen alters human testicular physiology including testosterone production
#29Earlier quoted context omitted.
Blame the journal. Scientists are generally pretty busy. Writing a (life sciences) paper is an incredible amount of work usually done in a short period of time. Preparing raw data and explaining what everything means is quite involved. If they don't have to do something they won't. The journal should mandate data access, then it will get done. This is crucial for human experiments, if only because the authors can los…
As far as I know this is slowly changing. According to scientists I've met (life science fields) there is an ongoing trend towards demanding raw data and even the code used to analyze it. Not every journal everywhere yet of course, but the consensus seemed to be that in 5 to 10 years it would become the new norm. Which might cause quite the disruption. Having seen quite the amounts of code written by PHD students I'm…
This is exactly the motivation behind the Loom file format[0] being developed and used in the molecular neurobiology-group I work for[1]. It is an HDF5-based file format for 'omics data, to deal with the ever-growing size of the data sets.
I specifically work on the Loom Viewer[1], a SPA that we're trying to design in such a way that it will be really easy and cheap for research groups to host and share these loom files themselves. This would make easy for other groups to ask simple questions about each others data, and in the worst case the raw loom file is always available for download.
We're already hosting some of our own published datasets with this viewer, you can check it out here[3].
To lower expectations a bit: the viewer is not trying to be comparable to the big atlases like [4] or [5] (I mean, it's being developed by one dude - me - so by comparison it's a no-budget OSS project). It's much simpler and basic - the idea is that if you use the Loom file format in your pipeline in a sensible manner, the viewer will more or less know what to do with the data.
[0] https://github.com/linnarsson-lab/loompy
[2] https://github.com/linnarsson-lab/loom-viewer
[3] http://loom.linnarssonlab.org/
Re: Ibuprofen alters human testicular physiology including testosterone production
#30Earlier quoted context omitted.
Nope, that is literally the dosage mentioned in leaflet inside my box of pills: 2x200mg, up to 3 times a day, do not exceed 6 weeks.
I'm not saying it's an overdose (and their tests of renal and hepatic function corroborate that) But it's not a dose people will commonly take in their "day to day" activities and ideally not something that is done without medical supervision
I went through a period of heavy physical activity without good equipment, which caused quite bad shin splints. My doctor prescribed precisely this dose, along with some physiotherapy. I think it's quite common for inflammatory problems like that.