The actual paper is paywalled. Can anyone tell what the sample size of the stud(ies) was?
It looks like between 4 and 9 per treatment group, depending on the experiment.
Doesn't that seem extremely small?
Activating circadian clock reduces brain cancer without side effects in mice
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Re: Activating circadian clock reduces brain cancer without side effects in mice
#22Earlier quoted context omitted.
It looks like between 4 and 9 per treatment group, depending on the experiment.
Doesn't that seem extremely small?
It does.. I didn’t notice that before posting the article here. But, possibly helping their case, at least some of the experiments were done on ears, so double the biological replicates.
Re: Activating circadian clock reduces brain cancer without side effects in mice
#23Pretty sure I have cancer. Context: https://news.ycombinator.com/item?id=15889203 FWIW I also have narcolepsy, which took until adulthood to diagnose and had far more devastating effects on my life: https://news.ycombinator.com/item?id=10984478 Didn't want to make this about me, but the coincidence between sleep problems and cancer is interesting enough that it seemed worth chiming in.
I developed narcolepsy in my teens and I can absolutely relate to how you feel. Everyone just thought I was lazy, malingering or, in the case of my general physician, depressed. It took years before I could even see a neurologist, after which an official diagnosis was quickly made. If you're not already on sodium oxybate (Xyrem), I can't recommend it enough; it's the only thing that puts me in a sound, restorative sl…
I'd suggest trying baclofen if you haven't. It doesn't work for everyone but it does work in some cases for both narcolepsy and circiadian issues and if it does work for you it is one of the better sleep drugs available (even if not usually considered as a sleep drug).
Re: Activating circadian clock reduces brain cancer without side effects in mice
#24Earlier quoted context omitted.
I don't think you should blame yourself about beggars, it's not hypocritical. I don't usually give any money to beggars too, because most probably they are related to some crime groups (someone takes away most of donated money from them) and/or will just spend the money on booze and that's it. On the other hand, I've bought stuff I don't need from beggar-like old women here (babushkas), who just knit socks/hats etc a…
> because most probably they are related to some crime groups (someone takes away most of donated money from them) Why is that "most probably"? Btw, you can give other things than money to beggars as well. Bread or a cup of coffee, for example.
Because that's how it is here (Russia). It's wide spread scheme - crime groups "cover" some territory (usually where there's a lot of walk traffic) and take money from all the beggars which stay on that territory.
Here you can see how beggar gives money to his criminal supervisor: https://www.youtube.com/watch?v=5TrRI1QyQ8g
There's a lot of info about it on youtube, but it's mostly in Russian. Beggars in good places can get 2-3 average salaries per month and most of those money goes to criminals. It's really ugly criminal business. As an example - there's such thing as "renting" small babies - because women with babies can gather more money. They drug babies so they would lie still in the hand of beggar women. So giving money to beggars is often same as giving funds to criminals here.
Re: Activating circadian clock reduces brain cancer without side effects in mice
#25Earlier quoted context omitted.
> because most probably they are related to some crime groups (someone takes away most of donated money from them) Why is that "most probably"? Btw, you can give other things than money to beggars as well. Bread or a cup of coffee, for example.
Because that's how it is here (Russia). It's wide spread scheme - crime groups "cover" some territory (usually where there's a lot of walk traffic) and take money from all the beggars which stay on that territory. Here you can see how beggar gives money to his criminal supervisor: https://www.youtube.com/watch?v=5TrRI1QyQ8g There's a lot of info about it on youtube, but it's mostly in Russian. Beggars in good places…
Thanks for the info, it had not even occurred to me that you could possibly be from Russia. I'm curious, do you agree giving a bread to a homeless person (in general, or in Russia specifically) makes sense?