I recommend Peter Attia's highly engaging and informative talk [0] on the same topic, which I think does a better job at articulating the motivation behind possible approaches to attacking the issue of health- and life-span.
Beginner's guide to longevity research
21–30 of 89 posts
Re: Beginner's guide to longevity research
#22Earlier quoted context omitted.
My diet is almost small these days but I'm very curious about IF... Hoping I'll have willpower to do one
Honestly, it takes less willpower to do IF than to not do it :p 1. Wake up 2. Make Breakfast 3. Go on with day vs 1. Wake up 2. Go on with day.
one shot are easy, it's the semblance of regularity that is important
Re: Beginner's guide to longevity research
#23Very interesting research, but trying to derive actionable recommendations for humans seems a bit laughable at this point. Still seems tough to become immortal these days. Harvesting young blood, a rigid diet, castration and starving yourself occasionally - lots of effort your self-absorbed wealthy investor with a desire to live forever has to go through. But then again, Sam Altman recently praised China for having f…
The reproduction angle is interesting, to me, anyway. The article only really talks about worms and then draws a vague link to Eunuchs - given social factors etc. neither is that meaningful.
What's more interesting is how my health/lifespan is impacted as a transwoman... Fertility is pretty badly hit by hormone therapy for both trans men and women, and in a few decades you should start having enough people to see how that actually affects outcomes. Of course... the social realities of being trans could confound that data. (E.g., being socially isolated is not good for your health)
Re: Beginner's guide to longevity research
#24This is a pretty fantastic writeup, short and simple on each topic with loads of sources. For those looking for something actionable, you may want to head to the reddit board for intermittent fasting. It's a good way to lower your caloric intake and increase autophagy. People doing intermittent fasting often also eat a keto diet that is mentioned in the writing as well. https://www.reddit.com/r/intermittentfasting/ h…
I have made many attempts at fasting. I'm skinny as a rake and get very weak without some kind of constant caloric intake. I also get "hangry" and make bad decisions on an empty stomach. Is this just me? Or is this a thing that everyone has and just works through?
1.) Start slow, you can start with something as short as 12hrs fasting (sleeping time counts) and just add an hour to that every week or two. Personally I added an hour as I get used to it. 14 hour fast and still not hungry yet? I'll add an hour to it this week. Now I generally just eat one meal per day unless I'm very active. 16hours fasting, 8 hours feeding window is the most common spot for people to stop.
2.) This is exactly why people who do intermittent fasting are often eating keto, which is a low carb, moderate protein, high fat diet. Carbs spike your blood sugar. Then it comes crashing down and puts you in a relative "low", so your body craves more of that quick energy and boom you are hungry/want carbs again.
Fats and proteins on the other hand give you a more stable energy level by not spiking your blood sugar as much. You stay full. The reason for only moderate protein is because excess protein is also turned into glucose through gluconeogenesis.
For the record my boyfriend is a black hole when it comes to food. He's fairly muscular and active so he gets hungry pretty quickly. But if he eats keto macros he can handle 1 meal a day too. He actually gets a bit sick eating carb heavy meals now.
I've seen people do it without doing keto and still get weight loss success, but a LCHF diet of some sort is the most common diet I see. Also the article mentions specifically keto diet linked to longevity.
Read through the sidebar info on the keto reddit if you want an idea of where to start.
Re: Beginner's guide to longevity research
#25Earlier quoted context omitted.
I have made many attempts at fasting. I'm skinny as a rake and get very weak without some kind of constant caloric intake. I also get "hangry" and make bad decisions on an empty stomach. Is this just me? Or is this a thing that everyone has and just works through?
1.) Start slow, you can start with something as short as 12hrs fasting (sleeping time counts) and just add an hour to that every week or two. Personally I added an hour as I get used to it. 14 hour fast and still not hungry yet? I'll add an hour to it this week. Now I generally just eat one meal per day unless I'm very active. 16hours fasting, 8 hours feeding window is the most common spot for people to stop. 2.) Thi…
Thanks for the encouraging response, I will definitely checkout the keto subreddit.
Re: Beginner's guide to longevity research
#26This is a pretty fantastic writeup, short and simple on each topic with loads of sources. For those looking for something actionable, you may want to head to the reddit board for intermittent fasting. It's a good way to lower your caloric intake and increase autophagy. People doing intermittent fasting often also eat a keto diet that is mentioned in the writing as well. https://www.reddit.com/r/intermittentfasting/ h…
My diet is almost small these days but I'm very curious about IF... Hoping I'll have willpower to do one
This is partially why I mentioned keto, keto keeps your blood sugar level very even so you don't get hungry as much. I find eating once per day to be quite easy as long as I eat the correct ratio of fat/protein/carbs. Also I worked up to eating once per day so that helped. (14 hrs for 2 weeks, then 15 hrs for 2 weeks, 16 hours for 2 weeks, etc.)
Re: Beginner's guide to longevity research
#27Earlier quoted context omitted.
1.) Start slow, you can start with something as short as 12hrs fasting (sleeping time counts) and just add an hour to that every week or two. Personally I added an hour as I get used to it. 14 hour fast and still not hungry yet? I'll add an hour to it this week. Now I generally just eat one meal per day unless I'm very active. 16hours fasting, 8 hours feeding window is the most common spot for people to stop. 2.) Thi…
Thanks for the encouraging response, I will definitely checkout the keto subreddit.
Yeah, came here to echo the idea that fasting is MUCH easier on a low carb diet. If you start reading about keto, you'll probably see the classic macro ratio of 75% fat, 20% protein, 5% carbohydrate – sometimes even higher percentage from fat.
My advice is that starting out, I wouldn't get too hung up on the ratio. It's actually pretty hard to get 75% of calories from fat. IMO, the important part is to limit the carbs. If you're hitting something like 60% fat, 30% protein, 10% good carbs (mostly green veggies, maybe some berries), you'll still see most of the keto benefits in terms of fewer mood swings and cravings, ability to fast more easily, etc.
Healthy eating is one of those areas where a lot of people (myself included) let perfect become the enemy of good. Even moderate low-carb, just eating cutting out sweets and starches, can be enough for a lot of people to see waistline and mood stability improvements.
Re: Beginner's guide to longevity research
#28[deleted]
Re: Beginner's guide to longevity research
#29This is an awesome write-up.
Regarding the experiment on monkeys that showed calorie restriction led to a longer life, there is one key point that I think damages the conclussion. Both groups of monkeys were fed an extremely unhealthy diet that was very high in sugar. So the conclusion would be that eating fewer unhealthy calories leads to a longer life, not that calorie restriction in itself does.
Re: Beginner's guide to longevity research
#30Very interesting research, but trying to derive actionable recommendations for humans seems a bit laughable at this point. Still seems tough to become immortal these days. Harvesting young blood, a rigid diet, castration and starving yourself occasionally - lots of effort your self-absorbed wealthy investor with a desire to live forever has to go through. But then again, Sam Altman recently praised China for having f…
Actionable things for humans at the moment appear to look like trying senolytic drug candidates in rational self-experimentation, with before/after tests of metrics linked to tissue stiffness, inflammation, kidney and heart function. Clearing senescent cells very clearly produces a degree of rejuvenation in mice, and can turn back progression of aging and specific age-related diseases via a sizable number of metrics.…
The problem with all potential senolytic drugs is cancer. Looking at all the animal models (and spontaneous human mutations) where senescence is reduced there is a corresponding increase in cancer. We really can't do much about ageing until we can cure or prevent cancer.