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As epidemic rages, ER study finds opioids no better than Advil and Tylenol

arstechnica.com

21–30 of 161 posts

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#21
post #10

Yeah, look, I staggered into the ER with a shattered collar-bone and a shitload of missing skin, and 10 mg of oxy had me feeling pretty much FINE while a nurse took a coarse sponge to scrub the asphalt out of my wounds. Overprescribed, yes. Comparable to OTC? Absolutely fucking not. Claiming that ibuprofen is as effective as diluadid or morphine is completely disingenuous.

[deleted]

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#22

Agreed that opiods are overprescribed, but for acute pain there's no comparison. At least in my experience. I was rushed to the ER with an excruciating condition, and i popped quite a bit of ibuprofen at home before going to the hospital (i think 4-6?). Nothing. In the triage room or whatever, that morphine drip (plus saline IV to replace all fluid i vomited up due to pain) made the 8/10 pain reduce to a 2-3/10, allo…

Watch out popping ibuprofen in large quantities, it is hepatoxic.

Isn't that Tylenol(the acetaminophen in it)? Ibruprofen screws up your kidneys I think.

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#23
post #9

Earlier quoted context omitted.

They didn’t say opioids are no better than either acetaminophen or ibuprofen; they said that opioids are no better than the combination of ibuprofen with acetaminophen — something very rarely prescribed (and usually advised against on the labels of both drugs.)

counter-anecdote: my doctor told me to use precisely that combination for severe pain. She said you cannot combine multiple NSAID's (ibuprofen, naproxen, ASA), but you can combine an NSAID with acetaminophen.

Same. In the hospital I was given small doses of morphine, and frankly I was shocked at how well it worked. I've had demerol for kidney stones, and it didn't do much for pain.

But the morphine at the hospital was like magic. And the dose low enough I didn't really feel any other effects.

That said, when it was time for discharge, the doc told me to alternate tylenol and advil every 2 hours (4 hour cycles each), as needed.

It wasn't news to me. I've followed the protocol before. I wasn't really in much pain by the time I was discharged, so I didn't bother with it this time and can't really compare.

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#24
post #9

Earlier quoted context omitted.

They didn’t say opioids are no better than either acetaminophen or ibuprofen; they said that opioids are no better than the combination of ibuprofen with acetaminophen — something very rarely prescribed (and usually advised against on the labels of both drugs.)

counter-anecdote: my doctor told me to use precisely that combination for severe pain. She said you cannot combine multiple NSAID's (ibuprofen, naproxen, ASA), but you can combine an NSAID with acetaminophen.

Agreed; I've been prescribed that combination more than once by different doctors. It's very common, and often the recommendation is to stagger them. NSAIDs are metabolized by the kidneys and acetaminophen is metabolized by the liver, so they can be safely combined.

EDIT: also, this is pretty much what Excedrin is (aspirin instead of ibuprofen, but NSAID + acetaminophen, plus also caffeine)

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#25

Earlier quoted context omitted.

Watch out popping ibuprofen in large quantities, it is hepatoxic.

Isn't that Tylenol(the acetaminophen in it)? Ibruprofen screws up your kidneys I think.

You're right. Tylenol trashes the liver, Advil hurts the kidneys and intestinal system.

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#26

Earlier quoted context omitted.

Watch out popping ibuprofen in large quantities, it is hepatoxic.

Isn't that Tylenol(the acetaminophen in it)? Ibruprofen screws up your kidneys I think.

Ibuprofen can cause liver damage in higher doses. It appears to happen almost randomly though, which suggests something unusual to the patient prompts the reaction.

https://livertox.nih.gov/Ibuprofen.htm

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#27
Of course while YMMV, I've found the same thing - I've been prescribed opioids for pain, and I found that Advil worked just as well, without the side effects. I do understand that opioids have their place - for example I was told that Advil was not safe to take before surgery so I was stuck with the prescription meds.

On example that made an impression on me: a couple of years ago, I had arthroscopic surgery on a knee. When the surgery was done and I was being discharged, a nurse came to me with a percocet script and told me to take one every xx hours. Having taken percocet in the past and being familiar with the aforementioned side-effects, I asked her if she wanted me to take it for pain management, or if there was another reason to take it (blocking the formation of blood clots for example). I'm fairly pain-tolerant, so if it was a pain management thing, I wasn't going to take it. Her response was "just take the pills." That was not helpful. If doctors and nurses are just shoving these things down patients' throats it's not surprising there is a problem out there.

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#28
As someone who actually ended up in ER with a badly broken ankle once, I beg to differ. After surgery, Percocet was the only reason I could sleep for the first few days. I got off it as soon as I could, though.

Edit: I just wanted to point out there are different degrees of “acute extremity pain”. There’s “I bumped my toe against a chair leg” kind, and then there’s “I can’t breathe because I’m in shock” kind. Opioids are appropriate for the latter.

Re: As epidemic rages, ER study finds opioids no better than Advil and Tylenol

#30
post #9

Earlier quoted context omitted.

They didn’t say opioids are no better than either acetaminophen or ibuprofen; they said that opioids are no better than the combination of ibuprofen with acetaminophen — something very rarely prescribed (and usually advised against on the labels of both drugs.)

counter-anecdote: my doctor told me to use precisely that combination for severe pain. She said you cannot combine multiple NSAID's (ibuprofen, naproxen, ASA), but you can combine an NSAID with acetaminophen.

We do this pretty often for the patients that come into our student run clinic. We aren't allowed to prescribe opioids, so we tell them to alternate ibuprofen and acetaminophen every 4 hours. Works pretty well, and doesn't stress your liver or stomach as hard.
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