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2016 Nobel Prize in Physiology or Medicine Is Awarded to Yoshinori Ohsumi [pdf]

nobelprize.org

21–30 of 31 posts

Re: 2016 Nobel Prize in Physiology or Medicine Is Awarded to Yoshinori Ohsumi [pdf]

#21
post #19

In case anyone is interested in the personal implications of this, this is part the mechanism by which intermittent fasting gains it's health benefits. People have fasted for 16-48 hours and gained benefits through history but what is happening in the body is really ketosis + autophagy. Most people in the modern world eat too frequently to benefit from autophagy, but men (16 hours of fasting) and women (14 hours of f…

>"3-4x faster cell recycling"

What is "cell recycling"?

Re: 2016 Nobel Prize in Physiology or Medicine Is Awarded to Yoshinori Ohsumi [pdf]

#22
post #4

Not to CRISPR - again!...

The Nobel committee is probably waiting for a resolution to a patent conflict regarding who invented it first, before they give it to crispr, see http://www.nature.com/news/bitter-fight-over-crispr-patent-h...

Whenever Lior Pachter points his guns it's time to get out the popcorn....

https://liorpachter.wordpress.com/2016/01/18/the-heroes-of-c...

Re: 2016 Nobel Prize in Physiology or Medicine Is Awarded to Yoshinori Ohsumi [pdf]

#23
post #19

In case anyone is interested in the personal implications of this, this is part the mechanism by which intermittent fasting gains it's health benefits. People have fasted for 16-48 hours and gained benefits through history but what is happening in the body is really ketosis + autophagy. Most people in the modern world eat too frequently to benefit from autophagy, but men (16 hours of fasting) and women (14 hours of f…

Please, everyone in the IT/CS world, ridiculous health "benefit" claims are in fact the origin of the term "snake oil." There is no accepted guidance from the biomedical community regarding fasting that draws a link to autophagy. Please keep your completely unscientific and unfounded health "benefit" claims to yourself.

Re: 2016 Nobel Prize in Physiology or Medicine Is Awarded to Yoshinori Ohsumi [pdf]

#24
post #21
post #19

In case anyone is interested in the personal implications of this, this is part the mechanism by which intermittent fasting gains it's health benefits. People have fasted for 16-48 hours and gained benefits through history but what is happening in the body is really ketosis + autophagy. Most people in the modern world eat too frequently to benefit from autophagy, but men (16 hours of fasting) and women (14 hours of f…

>"3-4x faster cell recycling" What is "cell recycling"?

Most of the news outlets reporting on this are using that term, which must have appeared in a press release. I think it's just a layman-friendly version of "autophagy".

Re: 2016 Nobel Prize in Physiology or Medicine Is Awarded to Yoshinori Ohsumi [pdf]

#25
post #21

Earlier quoted context omitted.

>"3-4x faster cell recycling" What is "cell recycling"?

Most of the news outlets reporting on this are using that term, which must have appeared in a press release. I think it's just a layman-friendly version of "autophagy".

Thanks, your assessment agrees with mine for whatever that is worth.

Re: 2016 Nobel Prize in Physiology or Medicine Is Awarded to Yoshinori Ohsumi [pdf]

#26
post #12

Earlier quoted context omitted.

The Nobel Prizes in science are generally awarded a few decades after the fact. That gives enough time for the impact of the work to become clear.

Very true. It took 8 years for Craig Mello and Andrew Fire to be awarded for RNAi (published 1998, awarded 2006 -- and that was considered fast). CRISPR as a gene engineering tool isn't even that old yet, so we've got a few years.

Counter example: yamanaka

Re: 2016 Nobel Prize in Physiology or Medicine Is Awarded to Yoshinori Ohsumi [pdf]

#27
post #20
post #16

Earlier quoted context omitted.

It's disappointing that the "prize is being giving in recognization ... better understanding of neurodegenerative diseases". My point is that I think the prize itself should honor scientific achievements, rather than medical ones, and that this discovery, on its own, stands as a fundamental biological understanding. That it helped understand neurodegenerative disorders is ancillary, and unecessary to justify the priz…

Alfred Nobel apparently disagreed, and it's still the interest on the money bequeathed by his will that funds the prize. So it's unlikely that the name will be changed.

Neither kind of restriction is applied to the physics or chemistry prize (they do not require some sort of nebulous "medical benefit" to qualify).

Re: 2016 Nobel Prize in Physiology or Medicine Is Awarded to Yoshinori Ohsumi [pdf]

#28
post #23
post #19

In case anyone is interested in the personal implications of this, this is part the mechanism by which intermittent fasting gains it's health benefits. People have fasted for 16-48 hours and gained benefits through history but what is happening in the body is really ketosis + autophagy. Most people in the modern world eat too frequently to benefit from autophagy, but men (16 hours of fasting) and women (14 hours of f…

Please, everyone in the IT/CS world, ridiculous health "benefit" claims are in fact the origin of the term "snake oil." There is no accepted guidance from the biomedical community regarding fasting that draws a link to autophagy. Please keep your completely unscientific and unfounded health "benefit" claims to yourself.

It seems as though many of your historical posts are similarly angry "source-your-claims" posts. Here is an article entitled "Short-term fasting induces profound neuronal autophagy": https://www.ncbi.nlm.nih.gov/pubmed/20534972/

Re: 2016 Nobel Prize in Physiology or Medicine Is Awarded to Yoshinori Ohsumi [pdf]

#29
post #25

Earlier quoted context omitted.

Most of the news outlets reporting on this are using that term, which must have appeared in a press release. I think it's just a layman-friendly version of "autophagy".

Thanks, your assessment agrees with mine for whatever that is worth.

Yes. It is a literal description of autophagy.

Re: 2016 Nobel Prize in Physiology or Medicine Is Awarded to Yoshinori Ohsumi [pdf]

#30
post #28
post #23

Earlier quoted context omitted.

Please, everyone in the IT/CS world, ridiculous health "benefit" claims are in fact the origin of the term "snake oil." There is no accepted guidance from the biomedical community regarding fasting that draws a link to autophagy. Please keep your completely unscientific and unfounded health "benefit" claims to yourself.

It seems as though many of your historical posts are similarly angry "source-your-claims" posts. Here is an article entitled "Short-term fasting induces profound neuronal autophagy": https://www.ncbi.nlm.nih.gov/pubmed/20534972/

Thank you for stalking. The paper you cite is preclinical work in mice, and the mechanistic association between starvation conditions and autophagy induction were already well understood before this paper. (That was, in fact, the Nobel-winning work on which you commented.) Any consequential claims of autophagy are unsupported by data in that paper, even in mice. The claim that autophagy has net "health benefits" or "life extension properties" in humans is completely unsupported and not something on which there is professional medical guidance.

HN is replete with medical and health claims that should not be propagated by responsible people. Face it: IT professionals don't have expertise in this area, but that doesn't apparently stop you from having opinions and propagating them authoritatively as truth. If you'd like to do original research in this area, please do, but don't spread misinformation as if it's factual.

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