http://tedxtalks.ted.com/video/Seeking-immortality-Aubrey-de...
More info on Aubrey de Grey:
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http://tedxtalks.ted.com/video/Seeking-immortality-Aubrey-de...
More info on Aubrey de Grey:
I'd like to believe you, but what kills people is not their age, today it's mostly cancer and heart disease. While I'd hope we'll make progress, I doubt those 2 will be just gone in 30 years.
The thing to take away here is that this is inevitable, but not necessarily for us, unless we dig in and get the job done right now. The development of the necessary technologies is very thinly funded, meaning that timelines are very uncertain. Senescent cell clearance may be under development in two US startups right now, a part of allotopic expression of mitochondrial DNA in clinical trials in France, clearance of one type of amyloid has had a successful trial in the UK, and clearance of glucosepane cross-links a couple of years away from a drug candidate, but other areas of biological repair needed for SENS-style rejuvenation of the old are still years away from getting to even this nascent stage. It is a miserable state of affairs given that the cost of progress towards prototypes in mice is a few hundred million, less than a single drug's development funding. Funding and advocacy make a huge difference at this point in the bootstrapping of rejuvenation therapies.
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Escape Velocity: Why the Prospect of Extreme Human Life Extension Matters Now
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC423155/
The escape velocity cusp is closer than you might guess. Since we are already so long lived, even a 30% increase in healthy life span will give the first beneficiaries of rejuvenation therapies another 20 years—an eternity in science—to benefit from second-generation therapies that would give another 30%, and so on ad infinitum. Thus, if first-generation rejuvenation therapies were universally available and this progress in developing rejuvenation therapy could be indefinitely maintained, these advances would put us beyond AEV. Universal availability might be thought economically and sociopolitically implausible (though that conclusion may be premature, as I will summarise below), so it's worth considering the same question in terms of life-span potential (the life span of the luckiest people). Those who get first-generation therapies only just in time will in fact be unlikely to live more than 20–30 years more than their parents, because they will spend many frail years with a short remaining life expectancy (i.e., a high risk of imminent death), whereas those only a little younger will never get that frail and will spend rather few years even in biological middle age. Quantitatively, what this means is that if a 10% per year decline of mortality rates at all ages is achieved and sustained indefinitely, then the first 1000-year-old is probably only 5–10 years younger than the first 150-year-old.
http://waitbutwhy.com/2015/01/artificial-intelligence-revolu...
I'd like to believe you, but what kills people is not their age, today it's mostly cancer and heart disease. While I'd hope we'll make progress, I doubt those 2 will be just gone in 30 years.
"The latest possible date a prediction can come true and still remain in the lifetime of the person making it is defined as The Maes-Garreau Point. The period equals to n-1 of the person’s life expectancy. This suggests a law: Maes-Garreau Law: Most favorable predictions about future technology will fall within the Maes-Garreau Point." http://kk.org/thetechnium/the-maesgarreau/
There exist a growing number of people propagating various forms of the viewpoint that we middle-aged folk in developed countries may (or might, or certainly will) live to see the development and widespread availability of radical life extension therapies. Which is to say medical technologies capable of greatly extending healthy human life span, probably introduced in stages, each stage effective enough to grant additional healthy years in which to await the next breakthrough. You might think of Ray Kurzweil and Aubrey de Grey, both of whom have written good books to encapsulate their messages, and so forth.
Some people take the view of radical life extension within our lifetimes at face value, whilst others dismiss it out of hand. Both of these are rational approaches to selective ignorance in the face of all science-based predictions. It usually doesn't much matter what your opinion is on one article of science or another, and taking the time to validate science-based statements usually adds no economic value to your immediate future. It required several years of following research and investigating the background for me to feel comfortable reaching my own conclusions on the matter of engineered longevity, for example. Clearly some science-based predictions are enormously valuable and transformative, but you would lose a lifetime wading through the swamp of uselessness and irrelevance to find the few gemstones hidden therein.
As a further incentive to avoid swamp-wading, it is generally well known that futurist predictions of any sort have a horrible track record. Ignoring all futurism isn't a bad attention management strategy for someone who is largely removed from any activity (such as issuing insurance) that depends on being right in predicting trends and events. You might be familiar with the Maes-Garreau Law, which notes one of the incentives operating on futurists: 'The Maes-Garreau Law is the statement that "most favorable predictions about future technology will fall within the Maes-Garreau Point", defined as "the latest possible date a prediction can come true and still remain in the lifetime of the person making it".'
If you want to be a popular futurist, telling people what they want to hear is a good start. "You're not going to be alive to see this, but..." isn't a compelling opening line in any pitch. You'll also be more convincing if your yourself have good reason to believe in your message. Needless to say, these two items have no necessary relationship to a good prediction, accuracy in materials used to support the prediction, or whether what is predicted actually comes to pass. These incentives do not make cranks of all futurists - but they are something one has to be aware of. Equally, we have to be aware of our own desire to hear what we want to hear. That is especially true in the case of predictions for future biotechnology and enhanced human longevity; we'd all like to find out that the mighty white-coated scientists will in fact rescue us from aging to death. But the laws of physics, the progression of human societies, and advance of technological prowess don't care about what we want to hear, nor what the futurists say.
I put value on what Kurzweil and de Grey have to say about the potential future of increased human longevity - the future we'll have to work to bring into being - because I have performed the due diligence, the background reading, the digging into the science. I'll criticize the pieces of the message I don't like so much (the timescale and supplements in the case of Kurzweil, WILT in the case of de Grey), but generally I'm on board with their vision of the future because the science and other evidence looks solid.
But few people in the world feel strongly enough about this topic to do what I have done. I certainly don't feel strongly enough about many other allegedly important topics in life to have done a tenth as much work to validate what I choose to believe in those cases. How should one best organize selective ignorance in fields one does care about, or that are generally acknowledged to be important? What if you feel - correctly, in my humble opinion - that engineered longevity is very important, but you cannot devote the time to validate the visions of Kurzweil, de Grey, or other advocates of longevity science?
The short answer is trust networks: find and listen to people like me who have taken the time to dig into the background and form our own opinions. Figuring out whether ten or twenty people who discuss de Grey's view of engineered human longevity are collectively on the level is not too challenging, and doesn't require a great deal of time. We humans are good at forming accurate opinions as to whether specific individuals are idiots or trustworthy, full of it or talking sense. Fundamentally, this establishment of a trust network is one of the primary purposes of advocacy in any field of endeavor. The greater the number and diversity of advocates to have taken the time to go digging and come back to say "this is the real deal," the more likely it is that that they are right. It's easy, and probably good sense, to write off any one person's views. If twenty very different people are saying much the same thing, having independently come to the same viewpoint - well, that is worth spending more time on.
One of the things I think we need to see happen before the next decade is out is the establishment of more high-profile longevity advocates who discuss advancing science in the Kurzweil or de Grey vein: nanotechnology, repairing the molecular damage of aging, and so on. Two, or three, or five such people is too few.
Life expectancy is skewed by infant mortality rates:
> Our conclusion is that there is a characteristic life span for our species, in which mortality decreases sharply from infancy through childhood, followed by a period in which mortality rates remain essentially constant to about age 40 years, after which mortality rises steadily in Gompertz fashion. The modal age of adult death is about seven decades, before which time humans remain vigorous producers, and after which senescence rapidly occurs and people die.
[1] https://condensedscience.wordpress.com/2011/06/28/life-expec...
PDF: http://www.anth.ucsb.edu/faculty/gurven/papers/GurvenKaplan2...
Earlier quoted context omitted.
It was mainly increasing because we almost made the death at birth close to zero. Now the gains are much harder to get on the other side.
Most people - at least most people here - know that a lot of those publicized numbers are due to infant mortality, but ... Post-childhood life expectancy has gone up in smaller amounts as the parent comment says. The grand numbers ("life expectancy was just 60 in 1900!") obviously reflect infant and childhood mortality, but we've increased the average lifespan in the United States by 2-3 years in the last few decades…