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Eating chocolate is associated with improved brain function

washingtonpost.com

21–30 of 101 posts

Re: Eating chocolate is associated with improved brain function

#21
post #11

I long for the day when these correlation-digging studies with absurd claims will stop. https://xkcd.com/882/

You should take a look at the journal article. They comment on how they corrected for multiple testing

"In addition to MANOVA, the Bonferroni procedure was used to protect against multiple comparisons."

The Bonferroni correction is one of the most conservative ways to correct for multiple testing.

https://en.wikipedia.org/wiki/Bonferroni_correction

Re: Eating chocolate is associated with improved brain function

#22

in my personal experience, eating chocolate has pushed me into IBS trouble, which i realized such a disease existed after 15 years. I stopped eating chocolate for the past 5 years. Now i am happy. Brain is a sugar sucker. Eat food which has natural sugar (like fruits) and you still be happy. Chocolate is just one sour junk which sugar added to please your bain (which is the trick). I think eat the chocolate without s…

Bitter, not sour. Lemons are sour.

forgive my english. its not my native.

Re: Eating chocolate is associated with improved brain function

#23
post #11

I long for the day when these correlation-digging studies with absurd claims will stop. https://xkcd.com/882/

You should take a look at the journal article. They comment on how they corrected for multiple testing "In addition to MANOVA, the Bonferroni procedure was used to protect against multiple comparisons." The Bonferroni correction is one of the most conservative ways to correct for multiple testing. https://en.wikipedia.org/wiki/Bonferroni_correction

The study is still 'correlation-digging'. Bonferroni won't fix the problem that these kinds of studies will throw up statistically significant associations that provide no insight into anything meaningful, due to confounders, biases, poor design etc. There is no equivalent xkcd however.

Re: Eating chocolate is associated with improved brain function

#24

in my personal experience, eating chocolate has pushed me into IBS trouble, which i realized such a disease existed after 15 years. I stopped eating chocolate for the past 5 years. Now i am happy. Brain is a sugar sucker. Eat food which has natural sugar (like fruits) and you still be happy. Chocolate is just one sour junk which sugar added to please your bain (which is the trick). I think eat the chocolate without s…

Its kind of cliche to target excess consumption of a rake and claim its terrible since you took the extreme cold turkey. All pleasures are best used moderately. Its an adage as old as good and evil itself.

Re: Eating chocolate is associated with improved brain function

#26
post #23

Earlier quoted context omitted.

You should take a look at the journal article. They comment on how they corrected for multiple testing "In addition to MANOVA, the Bonferroni procedure was used to protect against multiple comparisons." The Bonferroni correction is one of the most conservative ways to correct for multiple testing. https://en.wikipedia.org/wiki/Bonferroni_correction

The study is still 'correlation-digging'. Bonferroni won't fix the problem that these kinds of studies will throw up statistically significant associations that provide no insight into anything meaningful, due to confounders, biases, poor design etc. There is no equivalent xkcd however.

I don't think that anyone would take the results of this article as a statement of absolute fact. In the discussion they mentioned some more (better controlled) studies investigating the role of cocoa flavanols in "cognitive tasks". Doing any longitudinal study with humans suffer from confounders, biases, and poor design because we can't do controlled, long-term research on humans. You just have to take these limitations into account when you are interpreting the results and use any findings as areas for possible further investigation.

Re: Eating chocolate is associated with improved brain function

#27
The study is here[1; non-paywalled].

A series of follow-ups might look like this:

1: GWAS to look for genetic association with chocolate consumption.

2: Mendelian randomization to assess whether an inherent predisposition for increased chocolate consumption leads to increased cognitive function.

The same approach has been used to assess whether there is a dose-response of alcohol on mortality (the answer appears to be "yes," and there is no U-shaped curve).[2; non-paywalled]

This is mostly just to say that I'm not convinced by such tortured data in an association study, but if there is enough interest in the hypothesis, then the path forward to assess causality is clear.

1 = http://www.sciencedirect.com/science/article/pii/S0195666316...

2 = http://www.bmj.com/content/349/bmj.g4164

Re: Eating chocolate is associated with improved brain function

#28

in my personal experience, eating chocolate has pushed me into IBS trouble, which i realized such a disease existed after 15 years. I stopped eating chocolate for the past 5 years. Now i am happy. Brain is a sugar sucker. Eat food which has natural sugar (like fruits) and you still be happy. Chocolate is just one sour junk which sugar added to please your bain (which is the trick). I think eat the chocolate without s…

Why not eat unsweetened chocolate? Take it like a vitamin.

Re: Eating chocolate is associated with improved brain function

#29
post #23

Earlier quoted context omitted.

You should take a look at the journal article. They comment on how they corrected for multiple testing "In addition to MANOVA, the Bonferroni procedure was used to protect against multiple comparisons." The Bonferroni correction is one of the most conservative ways to correct for multiple testing. https://en.wikipedia.org/wiki/Bonferroni_correction

The study is still 'correlation-digging'. Bonferroni won't fix the problem that these kinds of studies will throw up statistically significant associations that provide no insight into anything meaningful, due to confounders, biases, poor design etc. There is no equivalent xkcd however.

There's more to it than just the things you mentioned, and I'd argue that it's an even bigger problem. The fact studies are adaptively chosen and performed based on the results of past studies on the same (or related) data leads to increased instances of false discovery. This is something that is directly addressed in some very recent recent work (not uncoincidentally making reference to this exact XKCD comic):

http://googleresearch.blogspot.com/2015/08/the-reusable-hold...

Re: Eating chocolate is associated with improved brain function

#30

Just as an FYI, I found a company recently that makes chocolate with zeor sugar, that's sweetened with Stevia: https://www.cocopolo.com/ I didn't like their dark chocolate, but their milk chocolate comes pretty close to regular milk chocolate.

Are you conserved with sugar per se, or the insulin response? Cocoa causes insulin spike even when sugar-free, iirc.
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