Maybe this actually part of a study to research whether having your research subjects pay you (rather than the other way around) has an effect the results of a study.
L-Theanine Experiment (1 Month)
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Re: L-Theanine Experiment (1 Month)
#22I tried taking L-Theanine for about 5 days. 30 minutes after taking it each day, I would get very nauseous and usually throw up. I tried varying the dosage from 200mg down to 100mg and then 75mg, I would still get the nausea, no matter if I had an empty stomach or not. I also get the same symptom when drinking more than a cup or so of green tea, and has for years (though I do remember being able to stomach the stuff…
If that's actually true (probably not), you have much bigger issues than L-Theanine.
Re: L-Theanine Experiment (1 Month)
#23This website almost certainly violates FDA rules on human subject experimentation because it collects data on the effect of a drug on human subjects. I would stop working on this project until you have advisors (and lawyers) who have experience with regulatory oversight from the FDA. At the bare minimum you are going to need (a) procedures to gain informed consent from trial enrollees and (b) an Institutional Review Board (IRB) to sign off on your trial. Depending on the drug, you might also need an FDA waiver to conduct the trial.
The PhD student (Rob Wagner) listed in the about section should have had at least one course on the responsible conduct of research. This course is required for most (all?) scientists working under a training or research grant from the NIH. Design and implementation of clinical trials--along with the ethical and legal issues involves--is standard fare for these courses for precisely this reason!
Re: L-Theanine Experiment (1 Month)
#24Earlier quoted context omitted.
You bring up a good point! We will be adding some outlines about ethics soon. Thanks for reminding us of the importance!
I'm sorry, you have a website called doubleblind, you are asking people to pay to participate in the study, and you need to be reminded of the importance of thinking about ethics? There's a reason why science and medicine don't move the same way Web 2.0 does (ie move quickly and break things). It's because people have died from poor implementations, and people trialing drugs are prone to exploitation from unscrupulou…
We chose L-Theanine because it has an excellent safety record, is well studied, and has no known toxic dose. We are very aware of safety and ethics. There are many nootropics and supplement companies safely distributing the same L-Theanine.
While we work through our protocol we will continue to dive into ethics and safety.
Re: L-Theanine Experiment (1 Month)
#25Hey! I've been taking L-Theanine for the past month. It feels to me like I've been waking up with a clearer mind, but it's super hard to know if that's form the l-theanine or just in general the change in the weather. So many variables.
Indeed it's difficult to tell - exactly the reason why a double-blinded trial on yourself can help you determine if it's making a significant difference or not :)
Re: L-Theanine Experiment (1 Month)
#26I tried taking L-Theanine for about 5 days. 30 minutes after taking it each day, I would get very nauseous and usually throw up. I tried varying the dosage from 200mg down to 100mg and then 75mg, I would still get the nausea, no matter if I had an empty stomach or not. I also get the same symptom when drinking more than a cup or so of green tea, and has for years (though I do remember being able to stomach the stuff…
Interesting. I've never heard of someone reacting to L-Theanine this way. Perhaps it could be an allergy?
Re: L-Theanine Experiment (1 Month)
#27I also love the idea, would really like to try it! Any chance to get it shipped outside the US (I live in Sweden)?
Not yet :( Like Steer said, you can still order Theanine independently of our company but I can let you know when we are ready for international orders if you send me your email!
Re: L-Theanine Experiment (1 Month)
#28I love the idea, but the execution seems less than ideal. Besides the research ethics question posed in another comment, what is the dosage of L-Theanine in the capsules? What kind of responsibility does the company take for possible side effects? I understand the side effects should be mild or non-existant in the experiment for L-Theanine, but just a discussion around that issue would be nice. Again, I want to stres…
What kind of responsibility does the company take for possible side effects? Probably the same kind of responsibility taken by green tea manufacturers.
Green tea sellers don't make medical claims for their products; green tea sellers don't enroll people in "research".
Re: L-Theanine Experiment (1 Month)
#29I absolutely love this idea. Are you gonna do a trial every month? Any schedule for which trials you're gonna run?
We're going to keep adding more trials - but there's no timeframe for when you have to start and end the trial. You can order it and start it whenever you receive it in the mail.
Re: L-Theanine Experiment (1 Month)
#30Earlier quoted context omitted.
What kind of responsibility does the company take for possible side effects? Probably the same kind of responsibility taken by green tea manufacturers.
Green tea sellers don't make medical claims for their products; green tea sellers don't enroll people in "research".
We make no medical claims about our product either - we only reference existing science.