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What Ozempic does to the gut-brain axis

psychologytoday.com

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Re: What Ozempic does to the gut-brain axis

#191
post #10

Tirzepatide at 1mg/week reduced my muscle soreness. I felt less depressed but this might just have been situational because I've been plagued by bad soreness after working out for years. Unfortunately after twelve weeks I had to stop because I felt a lot of nausea and tenderness in my upper abdomen, and was worried it might be pancreatitis developing. I'm not sure why it would happen at such a low dose but the sympto…

Might be worth trying live yogurt in the meantime, per the article?

Re: What Ozempic does to the gut-brain axis

#192

Earlier quoted context omitted.

To the others on this reply, I take 1/4 dose of the "clinical dose" and it has been life changing. I've lost 30 lbs. I've done that in the past, but for me that was harder than ranger school in the army. I LOVE food. Eating out and family dinner were always important to me. I was very worried that I would lose my pleasure in this. I haven't. But now I can just eat 1/2 slice of pie. Or 1 scoop of ice cream, etc etc. I…

I've been on Mounjaro for a couple of years. Unfortunately this effect seems to plateau somewhat and you have to bump your dose. I've changed doses 3 times now, so I'm pretty familiar with how long each increase lasts. It still provides some appetite control, but those initial gains, or the honeymoon phase, definitely tapers. Still, I'm better off being on it versus not and I think it allows me to maintain a healthy…

Did it still plateau on the highest dose?

Re: What Ozempic does to the gut-brain axis

#193
post #64

I got severely downvoted in the past for badmouthing GLP1s here. Then I did my research, got on them and I take it all back. These things are on par with statins in terms of potential societal impacts.

That says more about the harmful effects of obesity than anything.

That's kind of the point.

Re: What Ozempic does to the gut-brain axis

#194
post #56

What’s the downside to this magical drug. There has to be a downside…

And downsides of penicilin? There are some but they are massively offset by not having alt consequences

There are massive downsides to any antibiotic. A single dose of a broad-spectrum antibiotic can permanently alter a kid's gut microbiome and make them more likely to develop a variety of mental health issues like depression

https://theconversation.com/how-childhood-infections-requiri...

https://www.scientificamerican.com/article/a-single-course-o...

Re: What Ozempic does to the gut-brain axis

#195

Earlier quoted context omitted.

This is it. I am on GLP-1 (Zepbound). I have done Weight Watchers multiple times. I'd lose the weight for a little bit, then it would come back. The reason was _I was hungry all the time_. It's not sustainable. As someone else in WW told me: "The easy bit is losing the weight. The hard part is continuing to eat that way your whole life." It's simply a faulty hunger sensor in my body. It was not what I was eating, sim…

My friends who have been on it can genuinely enjoy food more now. There is no guilt. The portions make restaurant budgets more manageable. And they’re trying more of the menu. They liked food before. I think they can genuinely love it now, and that’s really great to experience with them, even aside from the massive lifestyle benefits losing weight brings.

Yes!

I was able to drink an Italian soda this week and not feel like "oh God I'm drinking my calories I'm going to be punished for this on the scales later".

Re: What Ozempic does to the gut-brain axis

#196

Earlier quoted context omitted.

I've been on Mounjaro for a couple of years. Unfortunately this effect seems to plateau somewhat and you have to bump your dose. I've changed doses 3 times now, so I'm pretty familiar with how long each increase lasts. It still provides some appetite control, but those initial gains, or the honeymoon phase, definitely tapers. Still, I'm better off being on it versus not and I think it allows me to maintain a healthy…

Did it still plateau on the highest dose?

I’m at 7.5mg now so can’t speak to any doses higher than that. But I’m assuming each step up would reintroduce more appetite control and reduce food noise and then level back off a bit. Not saying the effects go to zero, just that they start off more pronounced.

Re: What Ozempic does to the gut-brain axis

#197
post #10

Tirzepatide at 1mg/week reduced my muscle soreness. I felt less depressed but this might just have been situational because I've been plagued by bad soreness after working out for years. Unfortunately after twelve weeks I had to stop because I felt a lot of nausea and tenderness in my upper abdomen, and was worried it might be pancreatitis developing. I'm not sure why it would happen at such a low dose but the sympto…

Might be worth trying live yogurt in the meantime, per the article?

Yep one thing I did as part of going off tirzepatide was go immediately on a high fiber and fermented foods diet. It has helped a lot actually.

It's quite hard to maintain over time is all, I have a lot of social occasions where healthy choices are not really available, and from experience I know that over time I'll slowly drift back towards an unhealthy eating pattern. The modern world is just geared that way, unfortunately.

Re: What Ozempic does to the gut-brain axis

#198

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

The only underlying issue is an evolutionary mismatch: human evolution is too slow to keep pace with the modern abundance of food.

What we now call food addiction is exactly what kept our ancestors alive during famines.

Re: What Ozempic does to the gut-brain axis

#199
post #171

I'd take them even if they didn't make me lose weight - and I'm the type of person that doesn't like takeing Tylenol unless absolutely necessary. The best way I can describe it: my body and mind are no longer is in starvation mode. I plan, do, act and sleep well.

I had the same experience, but not with GLP-1 drugs, but by upping my protein intake to about 0.7g per pound of body weight. Night and day, stopped always being hungry... I've tried Noom before (eating highly filling, low calorie foods, but filling, not satiating), but that only worked while I was tracking (and always forcing myself to keep it up)... Losing weight required work on top of that, but the protein just ma…

I had a similar experience bringing down my A1C.

People talk a lot about meat, but not enough about dairy. My prayers were answered at the altars of feta, greek yogurt, half and half, butter, cottage cheese, etc. They made salads not suck. They opened up a ton of lower carb dessert options. My gut health improved. All of my health improved.

I no longer treat these humble foods as optional extras. They perfectly fill the gap in my daily protein needs. They were never unwelcome, just forgotten.

Re: What Ozempic does to the gut-brain axis

#200
post #177

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

The issue isn't food addiction, it's a broken hunger response (broken by Howard Moskowitz intentionally in the name of profits)... You have to change your food regimen completely (higher fiber, more protein, less sugar, less carbs, less fat), and that's tough to do when you're surrounded by options that aren't... I think the real problem is that the symptom we're trying to treat is "overweight", and it's actually a t…

We shouldn’t ignore grocery stores and marketing.

Aisles and aisles of sugar drinks and colorful sugar packaging.

The way society leaves it up to people to make their own decisions creates the problem at scale.

Society essentially has to take weekly injections to avoid the temptation of coca cola.

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