191–200 of 431 posts
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Even if you almost always end up paying the bill + 20% tip, Americans like the idea that they could not pay the tip if the service was bad.
The appearance of free action is appealing and preferable to being forced to pay the extra amount, even if you almost always pay the amount willingly anyway.
Peptides are a revolution and you don't need to know how they work to know that they work (for various people for various conditions). There is a tension between empiricism and fundamentalism with much of medical science focusing on fundamentalism. Now with the ability to collect and search large amounts of empirical data and communicate it peer-to-peer people are picking up on a lot of things that work without knowi…
This is a deeply unfair statement, and also a false dichotomy. Medical science is of course empiric. What you call "fundamentalism" is that compounds need to undergo a rigorous regiment of empiric testing before they are given to potentially millions of people. And no, it's not just because of Thalidomide. Many, many compounds fail clinical trials because of severe side effects, like liver toxicity, severe immune reactions or heart problems. Then there's of course increased risk of cancer, which can take many years to manifest itself empirically. You argue that you prefer living with these uncertainties rather than ME/CFS, and that's of course entirely understandable, but disparaging the field of medical science as focused on "fundamentalism" because we do not give large patient cohorts untested compounds is polemic. I understand where you are coming from, and I'm sorry that you suffer from this terrible condition, but likewise, you should try to understand the other side.
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> hamburgers and milkshakes don’t give you heart disease and cancer They absolutely do, particularly if you're getting most of your calories from them. If evidence-based medicine doesn't convince you, uh, hamburgers and supermarket milk tends to be processed.
They absolutely do not, unless you’re getting too many calories. Individual foods are—with some exceptions—neither bad for you nor good for you. A healthy diet can occasionally include doughnuts, and milkshakes. Your overall diet is what matters.
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> Still, hamburgers and milkshakes don’t give you heart disease and cancer. Overeating, oxidative stress from low-quality ingredients, etc might. What? “Oxidative stress”? Oh come on, at least go full “seed oil” if we’re going to talk nonsense.
We already left the land of reason far behind by the time OP implied hamburgers and milkshakes give people cancer.
Seed oils are not as bad as painted but some caution is needed given for instance the industrial processes used to bring them to market sometimes. Plus the way the oils are cooked when they create free radicals. This is not nonsense.
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Last I checked, Ozempic (Semaglutide) is around $1000/month in the US. A typical 1 month pen is 4-8mg, so around $250/mg to $500/mg. So yeah, I may have understated how much cheaper the gray market version is.
Semaglutide is effectively $99/month in the US. Not from shady sources.
Peptides are a revolution and you don't need to know how they work to know that they work (for various people for various conditions). There is a tension between empiricism and fundamentalism with much of medical science focusing on fundamentalism. Now with the ability to collect and search large amounts of empirical data and communicate it peer-to-peer people are picking up on a lot of things that work without knowi…
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I'm glad we have GLP-1, and I don't think there are really major side effects. But they are ineffective outside clinical trial setting for treating obesity. It seems to be like treating alcoholism with disulfiram: it's a miracle in clinical trials but in the real world the patients just lower the doses or discontinue treatment after 1-2 years and go back to their old habits.
> But they are ineffective outside clinical trial setting for treating obesity. This is one of the wildest claims I have ever seen on this website. Would you claim insulin is ineffective outside of clinical trials for treating type 1 diabetes because people have to keep injecting it?
Type 1 diabetes (or majority of diseases) doesn't involve addiction.
Dealing with doctors is kind of a pain in the ass. I was very sick a month ago and my doctor is pretty "anti antibiotics", he wanted me to go over for an in person check-in. This was after 10 days of having symptoms that I did everything reasonable to take care of. I got on a call with another doctor (at a perfectly reputable hospital) who immediately prescribed antibiotics. It took 5 days of antibiotics just to feel somewhat better - all while using saline rinses, showering, sleeping, eating properly, etc. I still have a lingering cough. I am very reluctant to take antibiotics unless it really feels necessary, this was easily the worst sinus infection of my adult life.
My friend wanted to try out a weight loss medication. Their doctor refused because they felt that my friend hadn't tried hard enough without it. So they got some from another friend who hadn't ended their prescription because they also were worried of being cut off. They've lost weight, which has motivated them to exercise more, eat better, and are generally happier and healthier.
From the article,
> Unfortunately, point two is that we barely have any of these effects worked out - at least not to the degree that you would want before you start injecting them into your leg.
This is what was said to a friend whose doctor took them off of one of those GLP medications, basically. They didn't have enough evidence to know the risks of continued use, even at lower doses.
The reality is simply that there's a big gap right now between what people want and what people have access to. The supplement industry exists to fill that gap.
Medical professionals can complain about users taking these peptides, but plenty of people are not "anti medicine" while still feeling underserved. If doctors aren't in a position to have these conversations, people will go to Youtube or wherever else to look for answers.
Personally, I have mixed feelings about a number of medications requiring a prescription. I frankly do not see why my doctor is involved in me taking a drug unless it would be negligent to allow me to or if it would have community health impacts (ie: antibiotic resistant strains etc). I'm an adult, if I've been properly informed of risks, etc, then I'm inclined to say that it should be up to me to pay full price for some medication or not.
I know plenty of people getting their GLP1 from compound pharmacies. None of them went their first, their doctors wouldn't give them the medication (sometimes they were just a pound under the BMI limit, often because they had been slowly losing weight) so they went elsewhere. These aren't anti-vaxxers who won't take their medication, they're people who want help and there's a gap that companies are taking advantage of. The medical establishment needs to find a way to address that. Right now the answer appears to be compound pharmacies and nurse practitioners.
> In my own view (and it ain’t just me) you also have regulatory agencies to force people to show that their drugs actually have some benefit before they can sell them, too. But that’s going further and further out of fashion. Can’t get ahold of the New Hotness to inject into your upper thigh if there are a bunch of stick-in-the-mud folks asking for human data, infringing on your freedom and all.
Many of us will be dead before there's a medically approved treatment for something. Hell, I got eye surgery before it was FDA approved - I'd probably be blind (or at least far worse off) if I'd waited the years it took.
How many people taking supplements are "naturopaths" who reject modern medicine as opposed to just people who want to be healthier? I really wonder that.