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Paracetamol disrupts early embryogenesis by cell cycle inhibition

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Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#191

Post by bitwize »

greesil wrote: post #46
bitwize wrote: post #12

Earlier quoted context omitted.

The vaccine-autism smoking gun that Andrew Wakefield and RFK Jr. heroically tried to find has, so far, failed to turn up. But there was a study recently that showed that autism is correlated with the mother taking acetaminophen during pregnancy.

Or maybe it's genetic. Or whatever. Cite yer sources matey, or it be all hot sargassum.

Arrh, be this good enough for ye?

https://hsph.harvard.edu/news/using-acetaminophen-during-pre...

https://ehjournal.biomedcentral.com/articles/10.1186/s12940-...

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#192

Post by JumpCrisscross »

astrange wrote: post #85
mctt wrote: post #79

Earlier quoted context omitted.

Yes, https://www.thisamericanlife.org/505/use-only-as-directed The episode shows how even small overdoses of acetaminophen can cause fatal liver damage, while decades of FDA delays and confusing drug labeling left millions of Americans at risk.

Tylenol is very safe if taken as prescribed. The overdose amount is relatively low, but not uniquely low. The alternatives are worse - ibuprofen destroys your stomach lining if taken at the regular dose for too long.

> Tylenol is very safe if taken as prescribed

I’ll note that if you aren’t used to taking Tylenol, be mindful of the difference between extra and regular strength. My dentist just wrote down a number of Tylenols to take every X hours, and I took them, but because they were extra strength I started hallucinating and chugging water during, I think, Detective Pikachu or some nonsense like it. My liver came out of it fine. But if I’d taken another handful poison control said they would have directed me to the ER. One more after that and it would have been permanent liver damage.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#193

Post by wildzzz »

hdgvhicv wrote: post #160
a3w wrote: post #42

Earlier quoted context omitted.

Most, if not all, medication would carry a poisonous symbol, if it were not taken out of regulation for that. Mostly, you kill organs by any overdose. Roughly: - Paracetamol overdose can cause severe liver damage and may be fatal. - Ibuprofen in high doses can lead to kidney injury and stomach bleeding. - Aspirin overdose may result in salicylate poisoning, causing ringing in the ears, confusion, and metabolic acidos…

You can overdose on water and oxygen too. What’s your point?

It's pretty hard to overdose on water unless you're in some state like extreme dehydration where water consumption needs to be overseen by a doctor. Unless you're talking about drowning, then you're just being silly. As a healthy adult, drinking too much water until the point that you're injured is hard to do. You likely need a mental disorder to ignore simple signals like "my stomach is very full right now". Whereas OTC medications can be very easy to overdose. If you don't read the instructions and regularly take more than recommended, you can injure your liver or other organs. Pills are not very big so a handful of them can easily be in the LD50 area.

Oxygen toxicity is not a risk for most people. You either are a scuba diver regularly working at depths beyond what most do or are taking supplemental oxygen while under the care of a doctor. You are not at risk of oxygen toxicity reaching into your bathroom medicine cabinet.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#195

Post by K0balt »

formerly_proven wrote: post #114
a3w wrote: post #42

Earlier quoted context omitted.

Most, if not all, medication would carry a poisonous symbol, if it were not taken out of regulation for that. Mostly, you kill organs by any overdose. Roughly: - Paracetamol overdose can cause severe liver damage and may be fatal. - Ibuprofen in high doses can lead to kidney injury and stomach bleeding. - Aspirin overdose may result in salicylate poisoning, causing ringing in the ears, confusion, and metabolic acidos…

- Metamizole has a tendency to kill some percentage of native Brits and their descendants. Yet globally it's one of the most popular painkillers, it's even OTC in countries with sufficiently low numbers of British and related people. (Has anyone ever done research to try and figure out why Brits are on the order of 1000x-10000x more sensitive to that side effect?)

> Brits are on the order of 1000x-10000x more sensitive to that side effect?

That is wild.

If true, it would have to be genetic? I mean, unless it is chronic dehydration from their sense of humor?

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#196

Post by Noe2097 »

sarchertech wrote: post #94
Noe2097 wrote: post #83

Isn't paracetamol forbidden in the US for pregnant women already? It is in other countries

No it’s the only allowed pain reliever for pregnant women in the US. It’s also allowed in the UK and the EU from what I can tell. What countries are you talking abou?

Sincere apologies, I mixed ibuprofen and paracetamol.

Ibuprofen is forbidden for pregnant women in the last 4 months in France at least - and by "forbidden", I mean "strongly advised against in a case of self medication".

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#197

Post by Noe2097 »

mynegation wrote: post #164
Noe2097 wrote: post #83

Isn't paracetamol forbidden in the US for pregnant women already? It is in other countries

You are probably thinking of ibuprofen which is considered non safe during pregnancy. Paracetamol is pretty much the only OTC pain relief medication that is recommended for pregnant women.

Yes indeed, you are absolutely right. Sorry about that.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#198

Post by akk0 »

Dave3of5 wrote: post #163
akk0 wrote: post #159

Earlier quoted context omitted.

I am familiar enough with the numbers that I am not necessarily surprised , but I still find it emotionally hard to grok that more than one in five would-be paracetamol suicide victims would be dissuaded by having to pop the pills out of a blister pack first.

Actually nowadays it's less that it's a problem to pop the pills out the booster pack and more that you are limited to the number you can buy. So if you're going to off yourself you'd have to stock pile or roam around shops picking up. There is a not insignificant number of suicides where people just say fck it I'll just kill myself but they don't want to go out to any real bother to do it i.e. they don't pre-plan it…

That's a different matter that wasn't mentioned though. Where I live (continental Europe) I've never seen any kind of medication as a bottle, but I'm also not aware of there being an amount restriction on paracetamol, which where I grew up in in the Netherlands can be bought in any supermarket. Interestingly I was surprised to find that in France paracetamol can only be sold in pharmacies but hard liquor is available in supermarkets.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#200

Post by nikolay »

littlestymaar wrote: post #183
nikolay wrote: post #154

Earlier quoted context omitted.

But it's the truth. Something that has just a 2% incidence should not dictate 98% of the treatments. Compromising the innate immunity of the 98% is more disgusting!

> But it's the truth. No it's not, in many case there's just no way the parent can tell something is about to go wrong. > Something that has just a 2% incidence should not dictate 98% of the treatments. This isn't the same argument, and I would agree if it was true, but you're distorting numbers as the actual prevalence estimations lie between 2 and 14%[1]. Now you could make the argument that 10% is low enough of in…

The vast majority of these seizures are benign. If your child had a febrile seizure, then there's a 30% chance of having it again, so, then you have some excuse to keep their fever under control (hopefully not with Tylenol as there are other antipyretics, too). Here's a nice summary by Gemini:

Key Takeaways

- No Lasting Damage: Simple febrile seizures do not cause long-term brain damage, intellectual impairment, or learning disabilities.

- Benign Nature: Despite how terrifying they are to witness, febrile seizures are considered benign events in the vast majority of cases.

- Focus on Reassurance: The primary goal for healthcare providers is to reassure parents and caregivers, providing them with the knowledge and tools to manage a fever and understand the low risk of lasting effects.

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