I highly, highly recommend uv. It solves & installs dependencies incredibly fast, and the CLI is very intuitive once you've memorized a couple commands. It handles monorepos well with the "workspaces" concept, it can replace pipx with "uv tool install," handle building & publishing, and the docker image is great, you just add a FROM line to the top and copy the bin from /uv. I've used 'em all, pip + virtualenv, conda…
Having said that, there are 2 areas where we still need conda:
- uv doesn’t handle non-python wheels, so if you need to use something like mkl, no luck
- uv assumes that you want to use one env per project. However with complex projects you may need to use a different env with different branches of your code base. Conda makes this easy - just activate the conda env you want — all of your envs can be stored in some central location outside your projects — and run your code. Uv wants to use the project toml file and stores the packages in .venv by default (which you don’t want to commit but then need different versions of). Yes you can store your project venv elsewhere with an env var but that’s not a practical solution. There needs to be support for multiple .toml files where the location of the env can be specified inside the toml file (not in an env var).