Earlier quoted context omitted.
I don't have to. We've had a nationwide epidemic of deaths from regulated, labeled opiates, which is a fact that refutes your argument without requiring me to provide an alternative.
You are making a claim then saying you don't have to back it up while making another dubious claim. Among synthetic opioid–involved overdose deaths in 2016, almost 80% involved another drug or alcohol, such as: another opioid, heroin, cocaine, prescription opioids, benzodiazepines, alcohol, psychostimulants, and antidepressants. https://www.cdc.gov/drugoverdose/deaths/other-drugs.html
> In 2021, nearly 71,000 drug overdose deaths involving synthetic opioids (other than methadone) occurred in the United States, which is more deaths than from any other type of opioid. Synthetic opioid-involved death rates increased by over 22% from 2020 to 2021 and accounted for nearly 88% of all opioid-involved deaths in 2021. The number of overdose deaths involving synthetic opioids in 2021 was nearly 23 times the number in 2013.
Same CDC page, "opioid" tab. https://www.cdc.gov/drugoverdose/deaths/opioid-overdose.html