Historically I’ve written several services that load up some big datastructure (10s or 100s of GB), then expose an HTTP API on top of it. Every time I’ve done a quick implementation in Python of a service that then became popular (within a firm, so 100s or 1000s of clients) I’ve often ended up having to rewrite in Java so I can throw more threads at servicing the requests (often CPU heavy). I may have missed somethin…
You have a single big data structure that can't be shared easily between multiple processes. Can't you use multiprocessing with that? Maybe mapping the data structure to a file and mmapping that in multiple processes? Maybe wrapping the whole thing in database instead of just using one huge nested dictionary? To me multi-threading sounds so much less painful than all the alternatives that I could imagine. Just adding…
While I hate how verbose and inexpressive it is, Go does hit a sweet spot of fairly good performance, even multi-core, while still being GCed so it's not nearly as foreign for a native python user.