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Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

nature.com

191–200 of 303 posts

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#191

Earlier quoted context omitted.

Also, 1 microbe is 1/1000000 of be.

Microbes are actually around 1 micrometer! Whilst I'd generally hate for a 1 meter bee to exist, it might be worth it just for the nerd joke. So purely factually, a microbe is only 1/10000th of a bee

> Whilst I'd generally hate for a 1 meter bee to exist

Luckily for you a rare sight - https://upload.wikimedia.org/wikipedia/commons/thumb/a/a4/Sa...

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#192
post #122

I'm sort of surprised they didn't extract/synthesize psilocybin directly and administer that. Decades ago, I grew a few batches of P. Cubensis. Even amongst mushrooms from the same rice cake, the dosage wildly varies. You could have a "trip" from a tiny mushroom or eat a handful of duds.

It might be so that researchers investigate the common practice of "microdosing" and its effects, not necessarily (just) the effects of psilocybin low dosage. So they tried to closely emulate this practice, as it is done by users in real-life. But this of course introduces more uncertainty, as you pointed out, so to have any conclusive results a much larger sample group would be needed, I think. Also I agree with oth…

I figured it was this as well - the motivation for performing the study is the anecdata from self-reports on microdosing with traditional techniques. I suspect that, if they had seen strong evidence for microdosing here - they would have moved on to investigating the effect in detail.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#193
post #77

Do mushrooms make you write incoherent ramblings on Facebook about how you are God and how everyone else is stuck in the matrix? Because I have 3 different friends who all started doing that after dabbling in psychedelics

Your friends are doing their best to connect with others and share their newfound perspective using whatever crude tools are available to them. Be kind. Psychedelics give you a new map into reality. If nobody teaches you how to read the map, it's easy to get lost or misread it. Integrating a bunch of different maps can be very challenging. Charitably, what they probably mean is that if we model god as the sum total o…

Playing into and encouraging other people's delusions isn't helping them.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#194

Been doing it for some months on & off, this shit is legit. Altough 0,5g has me tripping so I rarely dose above 100 milligrams. Get up early, do a workout, take cold shower, meditate and then pop a microdose shrooms, feels great. Microdosing is like steroids for meditation. Especially helpful for the programmer logic types of people like me, gets you out of your head for some time and helps you connect with your emot…

Does your daily routine change when you microdose? Do you still take the cold shower and meditate and all that regardless of it being a microdose day or not?

I found that when I was microdosing it made me way more mindful and apt to make "good/healthy" choices than normal. I think this is a tremendous benefit but for me very difficult to differentiate from a placebo effect.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#195
post #84
post #77

Do mushrooms make you write incoherent ramblings on Facebook about how you are God and how everyone else is stuck in the matrix? Because I have 3 different friends who all started doing that after dabbling in psychedelics

I’ve seen the observation that psychedelics evoke a sense of spirituality in people. I wonder if this is how people cope with that feeling of spirituality if they don’t participate in any organized religion?

The last time I took mushrooms with a friend they tried to talk me into joining them in worshiping Satan. Maybe you're onto something.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#196

I have been interested for quite some time to dabble with psilocybin but just haven't yet had the chance with buddies(outside of a work related traveling event) to do so. I absolutely refuse to try anything like this outside of an environment I have some level of control in or trust in the people around me(not the general public I.E: Bars, clubs, Vegas, etc). Any advice on what to avoid for a first timer from any exp…

The ideal would be to have someone with you during the trip that you are very comfortable with, since whatever emotion you might feel will be amplified. Even in that case tho, that person should know what to do, a little reading about how to trip sit would be the ideal, since for example asking “hey are you okay? You’re acting very weird” would be a bad idea.

In case you don’t have such person, for you first experience I would say that doing alone is better than doing with bad people or in crowded places. I would suggest tripping in a place you are comfortable with, with lots of blankets and pillows. For the first time I would avoid going outside, because even tho nature is astounding on trip, as a first time it could be a bit overwhelming. Prepare music that you like and gives good vibes to you. I personally prefer music without lyrics as those can be distracting. If you have a dog or a cat, know that they might act weird towards you, like if they are kind of scared. This is the setting.

The most important thing is that a trip is kind of like a roller coaster, once you get on it, you can’t get off until it finishes, meaning that you have to be open minded and ready to see and feel whatever your mind will show you. I personally like to think about people that I love in my life, and I explore the feeling inside of my body. This is the set.

If you are feeling like you are entering a thought loop, or negative thoughts, changing the setting (so changing music, going to another room) could help. At some point you will need to go to the bathroom. Be ready, the experience will be very weird, because the bathroom is usually smaller than other room, you are naked, and there are mirrors. For your first time I would suggest to avoid looking at yourself in the mirror, as the experience of seeing yourself aging or morphing could be quite disorienting.

If you need any more info there are subreddit that provide great source for everything you need. Have a safe trip!

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#197

It improves your mood, which quiets down the internal critic always shouting at you that what you’re creating is a waste of time. That’s probably the actual most important benefit.

Exactly, from personal experience I would say the effect of proper micro dosing is very similar to the benefits that experience meditators report when asked

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#198

Been doing it for some months on & off, this shit is legit. Altough 0,5g has me tripping so I rarely dose above 100 milligrams. Get up early, do a workout, take cold shower, meditate and then pop a microdose shrooms, feels great. Microdosing is like steroids for meditation. Especially helpful for the programmer logic types of people like me, gets you out of your head for some time and helps you connect with your emot…

> Been doing it for some months on & off, this shit is legit.

> Microdosing is like steroids for meditation.

I feel like I see a bit of wanting it both ways from people who like microdosing. There are lots of reports, like in this study, that the practice slightly (but only slightly!) lowers performance in most tests. On one hand, that's a pretty good trade-off as far as psychopharmaceuticals go. On the other hand, that's never how advocates present it. It's never "I'm a little less sharp but a lot happier."

My personal view of the situation is that the traditional view that psychedelics push peoples' mental mindsets away from those that work best with capitalist models of productivity is correct. Stoners really don't make 'good workers' (though a good worker could still gain a much needed respite by getting a little stoned here and there). But actually that is good! A drug that had mild side effects and allows you to be released from the productivity-focused conditioning of our work-culture is a really useful tool. You just shouldn't focus your advocacy on the idea that these drugs should be promoted on the off chance they increase productivity: because the mean case is not going to.

Edit: A clearer way to state what I mean is - occasional stoners probably do make more balanced workers - but they probably don't do their best work while they are stoned (or micro-stoned) and trying to insist they do seems unlikely to be the argument that decriminalized psychedelics.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#199
post #90

In studies such as these with huge intersubject variability, and probably also quite large intrasubject variability from day to day on many scales, it makes sense to look at change from baseline for individuals in the various groups rather than just differences in raw scores between treatment groups. It seems by a cursory glance that most analyses done were of the latter kind, and I think then a study such as this, w…

> it makes sense to look at change from baseline for individuals in the various groups rather than just differences in raw scores between treatment groups. That’s called cherry picking. Results are always noisy. You could give two groups of people the same tests on different days without any drugs at all and some subset would show “improvement”. If you start focusing on the individuals that show the result you want t…

They're not saying you should look at some subset of individuals with positive results, you have misread.

The notion is that the difference between participants can mask the effect of the drug, such that comparing any individual participant to anyone but themselves is improper.

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