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What can mRNA treat next?

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Re: What can mRNA treat next?

#191
post #183

Earlier quoted context omitted.

An alternative approach would be to learn enough to make mRNA “programs” that once inside a cell could determine cancerous vs healthy cells. There’s been research on computations using DNA, and many natural pathways do similar “calculations”, that it seems feasible to create a “if specific xyz protein/carbohydrate/etc in cell exceeds threshold trigger cell death pathways”. Then injection in a tumor mass should be suf…

You could maybe skip the cell death part, and instead trigger some existing telemetry systems that the immune system already watches for? At least then if something goes wrong, you could still be put on immunosupressants

From what I’ve read both are options. There’s benefits to getting the immune system to target cancerous cells Such as ongoing protection. Directly killing the cells is a good way to reduce tumor mass by direct injection however. The first t-cell immune treatments almost killed the patients due to liver/kidney overload from cellular debris as the immune system reacted too strongly, so being able to in cull tumor mass in a controlled fashion likely has merit as well. Either way the “detection method” would need to be very well tested and robust I imagine. Though the first treatments could be for “last chance” treatments that’d enable testing the safety of the particular detection method.

Re: What can mRNA treat next?

#193
post #64
post #53

Moderna has a public development pipeline. It shows they are working on, among other things, an HIV vaccine and vaccines/therapies for multiple types of cancer. https://www.modernatx.com/pipeline

Plus a flu vaccine: > mRNA vaccines [...] generate a much stronger immune response than responses that are generated to the protein in a normal flu vaccine [...] > One limitation of the current flu vaccines is that they take about six months to develop, meaning scientists must choose which strains they think will be prevalent in the next flu season — even before the current one is over. So by the time the vaccines ar…

VaC (Vaccine as Code)

Re: What can mRNA treat next?

#194
post #73

Earlier quoted context omitted.

OK, but that doesn't really answer my question. Turns out the answer can be found here: https://www.cdc.gov/flu/about/viruses/types.htm "There are four types of influenza viruses: A, B, C and D. Human influenza A and B viruses cause seasonal epidemics of disease (known as the flu season) almost every winter in the United States. Influenza A viruses are the only influenza viruses known to cause flu pandemics, i.e., gl…

One more piece of this is they endlessly mutate, I don't think in reality there is a limit. Most mutations probably don't help the virus proliferate, might cause it to not be effective. Eventually the shape of a new one, what your body is looking for in it's remembered virus history will change enough that it can't be detected. We see this in real time with the cv19 variants. My mental model of this (I am in software…

The lead time for pushing new "virus definitions" is a lot shorter once the vaccine is adopted and manufacturing chain is established. A central lab can download the new variants genome from labs all over the world, select some markers and push changes to manufacturing facilities through e-mail or even Git.

Re: What can mRNA treat next?

#195

Earlier quoted context omitted.

I haven't read anything related to treating autoimmune diseases with mRNA, that would be quite exciting. Do you happen to have a reference for this? I have Ulcerative Colitis, which is a form of an autoimmune disease. A vaccine as a cure would be a game changer.

But I thought we don’t really know what causes UC. Fungi? Bacteria? Genetic factors? Something else?

You're correct, doctors/biologists still do not know the root cause of IBD (UC/Chrons). In fact, most autoimmune diseases are quite poorly understood due to the vast dimensional space that can influence the human immune system. If there is evidence that it could be controlled via an mRNA vaccine, it would give me much hope for the future of controlling autoimmune diseases without consistent drug intervention or surgery.

Re: What can mRNA treat next?

#197
post #94

Earlier quoted context omitted.

Although given how we've squandered (and continue to squander) antibiotics, future generations may view bacterial diseases the way past generations did.

i think necesity here is for to block third world from acquisition of new antibiotic drug. there is where new superbug are arise. maybe it kill many there, but it also save many American here in longer term. in such 3world country, misuse/overuse of antibiotic are make for development of resistant. then poor sanatation are make for it easy for to spread to other persons. https://wwwnc.cdc.gov/eid/article/5/1/99-0103_…

Dude, it's not developing country misuse of antibiotics that's the problem. It's pouring it into animal feed in factory farms. It's doctors in wealthy countries giving their patients an antibiotic prescription for a viral infection because their patients expect them to "do something." You're not getting downvoted for using "third world" you're getting downvoted for speaking from a position of ignorance.
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