Earlier quoted context omitted.
An alternative approach would be to learn enough to make mRNA “programs” that once inside a cell could determine cancerous vs healthy cells. There’s been research on computations using DNA, and many natural pathways do similar “calculations”, that it seems feasible to create a “if specific xyz protein/carbohydrate/etc in cell exceeds threshold trigger cell death pathways”. Then injection in a tumor mass should be suf…
You could maybe skip the cell death part, and instead trigger some existing telemetry systems that the immune system already watches for? At least then if something goes wrong, you could still be put on immunosupressants
What can mRNA treat next?
191–197 of 197 posts
Re: What can mRNA treat next?
#192Re: What can mRNA treat next?
#193Moderna has a public development pipeline. It shows they are working on, among other things, an HIV vaccine and vaccines/therapies for multiple types of cancer. https://www.modernatx.com/pipeline
Plus a flu vaccine: > mRNA vaccines [...] generate a much stronger immune response than responses that are generated to the protein in a normal flu vaccine [...] > One limitation of the current flu vaccines is that they take about six months to develop, meaning scientists must choose which strains they think will be prevalent in the next flu season — even before the current one is over. So by the time the vaccines ar…
Re: What can mRNA treat next?
#194Earlier quoted context omitted.
OK, but that doesn't really answer my question. Turns out the answer can be found here: https://www.cdc.gov/flu/about/viruses/types.htm "There are four types of influenza viruses: A, B, C and D. Human influenza A and B viruses cause seasonal epidemics of disease (known as the flu season) almost every winter in the United States. Influenza A viruses are the only influenza viruses known to cause flu pandemics, i.e., gl…
One more piece of this is they endlessly mutate, I don't think in reality there is a limit. Most mutations probably don't help the virus proliferate, might cause it to not be effective. Eventually the shape of a new one, what your body is looking for in it's remembered virus history will change enough that it can't be detected. We see this in real time with the cv19 variants. My mental model of this (I am in software…
Re: What can mRNA treat next?
#195Earlier quoted context omitted.
I haven't read anything related to treating autoimmune diseases with mRNA, that would be quite exciting. Do you happen to have a reference for this? I have Ulcerative Colitis, which is a form of an autoimmune disease. A vaccine as a cure would be a game changer.
But I thought we don’t really know what causes UC. Fungi? Bacteria? Genetic factors? Something else?
Re: What can mRNA treat next?
#196Do the concerns raised here have any merit? https://osf.io/epr24/
Re: What can mRNA treat next?
#197Earlier quoted context omitted.
Although given how we've squandered (and continue to squander) antibiotics, future generations may view bacterial diseases the way past generations did.
i think necesity here is for to block third world from acquisition of new antibiotic drug. there is where new superbug are arise. maybe it kill many there, but it also save many American here in longer term. in such 3world country, misuse/overuse of antibiotic are make for development of resistant. then poor sanatation are make for it easy for to spread to other persons. https://wwwnc.cdc.gov/eid/article/5/1/99-0103_…