Live data from Hacker News

What Ozempic does to the gut-brain axis

psychologytoday.com

181–190 of 555 posts

Re: What Ozempic does to the gut-brain axis

#181

Earlier quoted context omitted.

> evidence of where their fat stores came from? Yes. Specifically, how basal metabolism is not a consciously-controlled rate that modifies itself against diet and exercise to the point that in some people with serious metabolic syndrome it may be impossible for them to lose weight through diet and exercise without suffering nutritional shortfalls. Also, the clinical evidence around what works for people losing weight…

Third party private healthcare decisions are almost non-existant in the US due to the payment systems. People are on the hook for the decisions of others either through their premium, taxes, or both. Of course, this is non-central and rarely the concern people present. That said, 2026 US GLP-1 healthcare sales projections run between 60 and 100 billion [1]. it will be interesting to see if these miricle drugs can rea…

> Third party private healthcare decisions are almost non-existant in the US due to the payment systems

The payment part is almost entirely pushing against GLP-1 agonists. Nobody has a long-term financial stake in patient costs to care that lifetime costs will likely be lower; insurers are just looking at the next couple years against expected churn. Another cost of tying health insurance to employment.

Re: What Ozempic does to the gut-brain axis

#182

My insurance stopped covering, now I'm looking at $450 for Zepbound / month. Just the weight coming back is making me more depressed...

Without long term positive dietary changes most people are unlikely to keep the weight off unless you want to take this stuff for life.

I have to exercise and go to the gym for life already?

Re: What Ozempic does to the gut-brain axis

#183

Earlier quoted context omitted.

Plenty of people have lifelong drug use of, say, caffeine, or aspirin as a blood thinner, or various antihistamines. Why is this somehow worse? Particularly keeping in mind that it's very easy to make, so once the patents expire, it's going to be dirt cheap as generics everywhere.

I'm just sharing my personal preference and not trying to tell people how to live their lives. I don't like personally like the idea that I'll only be healthy if I take this drug for the rest of my life when I could (again - speaking for me), be more disciplined about the food I put into my body.

[deleted]

Re: What Ozempic does to the gut-brain axis

#184

Earlier quoted context omitted.

> that will take that away from me They don’t stop eating, just overeating. Getting joy from food is different from self medicating with overconsumption. (For the record, I love food. I also don’t have an issue maintaining a healthy weight and physique.)

This is it. I am on GLP-1 (Zepbound). I have done Weight Watchers multiple times. I'd lose the weight for a little bit, then it would come back. The reason was _I was hungry all the time_. It's not sustainable. As someone else in WW told me: "The easy bit is losing the weight. The hard part is continuing to eat that way your whole life." It's simply a faulty hunger sensor in my body. It was not what I was eating, sim…

My friends who have been on it can genuinely enjoy food more now. There is no guilt. The portions make restaurant budgets more manageable. And they’re trying more of the menu. They liked food before. I think they can genuinely love it now, and that’s really great to experience with them, even aside from the massive lifestyle benefits losing weight brings.

Re: What Ozempic does to the gut-brain axis

#185

My insurance stopped covering, now I'm looking at $450 for Zepbound / month. Just the weight coming back is making me more depressed...

I get mine on the black market, 50c/mg for semaglutide, $3 per month at my current rate of usage. I’ve been on it for years, I was getting gray market at $12/mg for 3 years before RFK clamped down on that market. It’s exactly the same stuff (for me, no guarantee for others), had it tested in a lab and as the side effect profile is on point. It massively relieved my ME/CFS, back when I started there was no way I could…

GRAY market is way undercounted in peptide use. Go to the gym and there's like 25% of the people there taking gray market peptides (some for weight, some for injury repair, etc)

Re: What Ozempic does to the gut-brain axis

#186

I'd take them even if they didn't make me lose weight - and I'm the type of person that doesn't like takeing Tylenol unless absolutely necessary. The best way I can describe it: my body and mind are no longer is in starvation mode. I plan, do, act and sleep well.

As a counter example, I found myself unable to eat anything at all even with anti nausea meds, and my head utterly in a fog that felt like I was becoming ill.

Re: What Ozempic does to the gut-brain axis

#187

What’s the downside to this magical drug. There has to be a downside…

Some downsides:

1. They make you stop eating, which for most of human history kills you.

2. They are a life-long treatment and kind of expensive unless you go gray market.

3. Gastrointestinal issues especially when titrating up.

Re: What Ozempic does to the gut-brain axis

#188

I got severely downvoted in the past for badmouthing GLP1s here. Then I did my research, got on them and I take it all back. These things are on par with statins in terms of potential societal impacts.

It’s so funny, because they did well for you you’re now incredibly on board for all of society.

I tried them and my health got massively worse and I couldn’t eat at all, on a sub minimum dose.

Re: What Ozempic does to the gut-brain axis

#189

Earlier quoted context omitted.

I'm not on GLP-1s, but I've been looking at very seriously because something I can't "fix on my own" is just... always feeling hungry. That's just how my body works. Exercise doesn't help; there's no reasonable amount of exercise that will help with my office-worker stomach wanting 3000 calories a day. So far through my life I've just lived with it and managed my diet as best I can and it just absolutely sucks.

Why would exercise use help? Burning calories makes your body want to eat, obviously - this is how our bodies are supposed to work.

Exercise absolutely helps as it helps regulate blood sugar more effectively. A surprising effect of building muscle and exercising is that your body becomes more insulin sensitive and your blood sugar stabilizes instead of having drastic swings.

Re: What Ozempic does to the gut-brain axis

#190

Hasn't done jack shit for my depression. Also worth mentioning GLP1's are known to cause anhedonia. So there's that...

I can say the things I like, I like the same or even more (higher sex drive is one noted example). I can sit and program for hours now without thinking about other things. I assume this is what people who took Ritalin felt.

I do notice it makes it harder for me to get up and do certain harder, outdoor chores.

Post reply on HN