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Study finds no evidence cannabis helps anxiety, depression, or PTSD

sciencedaily.com

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Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#181

Post by Hobadee »

jounker wrote: post #172
wahern wrote: post #23

Earlier quoted context omitted.

> but remember there was a period of time where many seemingly forgot about their addictive properties. There was also quite alot of talk about how doctors, by being reticent to prescribe opioids, were inhumanely forcing patients to live in pain, and not being sufficiently deferential to patient autonomy. Moreover, the rhetoric was incorporated into discussions about racist disparities in treatment, given there was s…

As an aside, it is a well established fact that doctors, as a whole, take the the pain of black people much less seriously than the pain of non-black people.

> it is a well established fact

[Citation Needed]

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#182

Post by GorbachevyChase »

Kon5ole wrote: post #66

American media has really been shockingly pro weed/cannabis for the past 20 or so years. Really astounding to witness considering the well known downsides to human health and cognitive function. Main characters smoke weed as a cool disobedience, in sitcoms even. Wonder what is behind it, from my perspective it's quite remarkable.

I think there’s probably some adjacency to other things which make people feel good, but are ultimately bad for them. Gambling, alcohol, porn, infinite scroll social media. There are a few people making a ton of money on this stuff and the social costs aren’t something they care about.

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#184

Post by yosame »

andoando wrote: post #153
dns_snek wrote: post #125

Earlier quoted context omitted.

That's a terrible oversimplification. Stimulant treatments for ADHD are not supposed to produce pronounced mood-enhancing effects. Stimulant treatment has been shown to be effective indefinitely in majority of people without increasing the dosage over time. These days formulations like lisdexamfetamine and extended release methylphenidate are preferred because they have all-day efficacy with typical duration of actio…

extended release are just two doses of the drug where half the beads are delayed by ~4 hours. How is that different from taking two edibles a day and claiming full day efficacy?

I mean the difference is that you just take one in the morning? Which makes adherence easier, makes sure that the delay is constant rather than variable, and reduces abuse liability.

(As an aside, there are more complex extended release mechanisms than just delayed bead release - like lisfexamfetamine is a inactive prodrug, so cleaving the lysine off the amphetamine is rate limited. This has the effect of extended the duration of effect, and reduces the potential to abuse by snorting/iv/etc).

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#185

Post by flyingkiwi44 »

j45 wrote: post #112
anewcolor wrote: post #105

Earlier quoted context omitted.

we don't understand the brain well enough for images to be of any use. amen is a fraud.

Would love to learn more about how this is the case (both assertions). Mind sharing? Neuroscience seems to be coming through with more and more understanding using technologies like fMRI and others the past 5-10 years. There is definitely some understanding there.

Amen Clinics have been covered on sciencebasedmedicine.org a few times (2008 and 2013) from the look of it.

https://sciencebasedmedicine.org/spect-scans-at-the-amen-cli...

https://sciencebasedmedicine.org/dr-amens-love-affair-with-s...

Both https://sciencebasedmedicine.org and https://theness.com/neurologicablog/ are good resources for detailed research into science and medicine. With Neurologica having some good deep dives into Neuroscience topics https://theness.com/neurologicablog/category/neuroscience/ as the author is a recently retired academic clinical neurologist

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#186

Post by jrflowers »

> “Though our paper didn’t specifically look at this, the routine use of medicinal cannabis could be doing more harm than good by worsening mental health outcomes, for example a greater risk of psychotic symptoms and developing cannabis use disorder, and delaying the use of more effective treatments,” he said.

I like how confident the author is to just say stuff that’s not covered by his study while promoting his study.

“I didn’t look into this but I bet pot is bad!” doesn’t solicit a lot of confidence in the neutrality of the guy who previously brought us hits like “Does smoking weed lead to doing heroin?” and “Is ChatGPT good for doing medical research?”

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#187

Post by snissn »

I’m digging through the paper. It’s a meta analysis paper.. they have six studies they analyze on anxiety treatment and they (footnotes 40-46) have positive results in terms of cbd showing a significant effect on anxiety reduction. I’m not invested in figuring out exactly how this study came to represent what it claims but it seems like a joke

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#188

Post by snissn »

snissn wrote: post #187

I’m digging through the paper. It’s a meta analysis paper.. they have six studies they analyze on anxiety treatment and they (footnotes 40-46) have positive results in terms of cbd showing a significant effect on anxiety reduction. I’m not invested in figuring out exactly how this study came to represent what it claims but it seems like a joke

Ok I see so they have six studies that they found to indicate effective treatment of anxiety with cannibanoids but their meta study only found six trials with 50 people so the significance / n count is not high enough. So the study is a null result ie they don’t have enough data not they’ve disproved it. In fact their data supports the hypothesis. Then the coverage on science daily misrepresented this. Here's citaiton 40: https://www.nature.com/articles/npp20116 "Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients" Pretreatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alert in their anticipatory speech. The placebo group presented higher anxiety, cognitive impairment, discomfort, and alert levels when compared with the control group as assessed with the VAMS.

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#189

Post by shakna »

Hobadee wrote: post #181
jounker wrote: post #172

Earlier quoted context omitted.

As an aside, it is a well established fact that doctors, as a whole, take the the pain of black people much less seriously than the pain of non-black people.

> it is a well established fact [Citation Needed]

One of many, many citations: [0]. This is not something surprising, it's been ongoing since before the USA was a country.

[0] https://www.mayoclinicproceedings.org/article/S0025-6196%282...

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#190

Post by jdejean »

ecshafer wrote: post #77
Kon5ole wrote: post #66

American media has really been shockingly pro weed/cannabis for the past 20 or so years. Really astounding to witness considering the well known downsides to human health and cognitive function. Main characters smoke weed as a cool disobedience, in sitcoms even. Wonder what is behind it, from my perspective it's quite remarkable.

Since the 1960s and the emergence of the New Left, and the introduction of the Frankfurt School and 60s post modernism into academia, there has been a widespread belief amongst a large segment of the population that everything traditional is wrong. A social stigma is merely ignorance, that which is seen as bad is actually good, traditions are wrong. All of these things need to be overturned for the enlightenment. Sin…

What an intellectually bankrupt take; Extremely convincing until you realize less than 50% of people in the 60s even finished high school, and less than 8% of them even attempted post secondary education. Rejection of traditional values post 95 is attributable to any number of side effects of humans participating in the internet. We realized the scale of antiquated regulation. Something the “traditional media” would’ve never bothered to cover. This post is about weed not some soap box for your silent generation tears.
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