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Paracetamol disrupts early embryogenesis by cell cycle inhibition

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Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#181

Post by whazor »

thayne wrote: post #173
whazor wrote: post #76

Earlier quoted context omitted.

This send me into a whole rabbit hole. Mostly children get paracetamol overdose. Then I learned that in US/UK kids get paracetamol in liquid form with all kinds of flavours. Which is much harder to dose correctly when the kid spits or drools it out. Total culture shock for me, as in Europe the default for children is rectal ingestion (which is probably a culture shock as well for Americans). Any how, with pills it is…

As someone in the US, I've only used liquid tylenol for my kids when they were infants and pills were a choking hazard. Otherwise, it's much easier to get them to take a pill than drink a liquid.

Rectal pills use a different route than oral ones and are very safe.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#183

Post by littlestymaar »

nikolay wrote: post #154
littlestymaar wrote: post #124

Earlier quoted context omitted.

> risks of febrile seizures are overstated and if you're a responsible parent, not a lazy one, you can see if things are going South Not always. Blaming “lazy” and irresponsible parents is disgusting.

But it's the truth. Something that has just a 2% incidence should not dictate 98% of the treatments. Compromising the innate immunity of the 98% is more disgusting!

> But it's the truth.

No it's not, in many case there's just no way the parent can tell something is about to go wrong.

> Something that has just a 2% incidence should not dictate 98% of the treatments.

This isn't the same argument, and I would agree if it was true, but you're distorting numbers as the actual prevalence estimations lie between 2 and 14%[1].

Now you could make the argument that 10% is low enough of incidence it shouldn't dictate the treatment of the other 90%, but that's not what you're doing, instead you are blaming helpless parents and cherry picking numbers, making nothing but noise.

Oh, and by the way, most parents aren't in fact giving their kids paracetamol for that particular reason (as most parents are simply unaware of the existence of febrile seizures), but to help their children sleep and rest (and so themselves can sleep). And in fact, resting being key in innate immunity efficiency, I'm not particularly convinced about the effectiveness of letting your kids cry all night because of the pain and fever. You do what you want with your own kids, but there's no justification for insulting other parents.

Good day.

[1]: https://www.bmj.com/content/351/bmj.h4240

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#184

Post by littlestymaar »

thayne wrote: post #171
littlestymaar wrote: post #105

Earlier quoted context omitted.

> someone uneducated about it who is really suffering could easily take 3 or 4 times the dose. And the solution is simple: educate people about that. And it's not something hard to do, just have pharmacists say “respect the dose as it will kill you if you don't” every time they sell things and it'll work.

But Tylenol/acetaminophen/paracetamol is an over the counter drug, so there is no pharmacist involved in most sales. And I certainly wouldn't count on everyone reading the tiny text on the bottle.

That's entirely a sales (de)regulation problem though.

It's funny that in a country where you can win massive sums of money on stupid trials a drug like paracetamol is sold without supervision.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#185

Post by vanderZwan »

antonkochubey wrote: post #77
vanderZwan wrote: post #55

Earlier quoted context omitted.

What about ginger? Because that apparently only downregulates COX-2 without affection COX-1 (most inflammation-reducing drugs affect both)

Etoricoxib does just that and is widely available at least in the EU

Interesting, I didn't know. My original question was more about whether that affects muscle gains differently though, do you happen to have any insights into that?

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#186

Post by epgui »

bitwize wrote: post #174
alwa wrote: post #170

Earlier quoted context omitted.

In gp’s defense—I interpreted their formulation to suggest vaccine skeptics applied effort to an heroic degree/amount, not that the effort was of heroic virtue. That is, that those people applied ridiculously high levels of effort to searching for an effect, and still did not find an effect. As distinct from the retort that “absence of evidence is not evidence of absence”: It can be, if you’ve tried hard enough to ga…

I was being highly, highly sarcastic. People still banging the vaccine-autism drum are heroes only in their own mind.

Thanks for clarifying, it was really not obvious given the incredible prevalence of vaccine skepticism!

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#187

Post by epgui »

alwa wrote: post #170
epgui wrote: post #40

Earlier quoted context omitted.

> Andrew Wakefield and RFK Jr. heroically tried to find I'm not sure if that was supposed to be sarcastic, but these two people have done more harm to public health, and are responsible for more health dis/mis-information, than pretty much anyone I can think of. (I am a biochemist, no conflict of interest)

In gp’s defense—I interpreted their formulation to suggest vaccine skeptics applied effort to an heroic degree/amount, not that the effort was of heroic virtue. That is, that those people applied ridiculously high levels of effort to searching for an effect, and still did not find an effect. As distinct from the retort that “absence of evidence is not evidence of absence”: It can be, if you’ve tried hard enough to ga…

Yeah that was my charitable reading as well, but with the incredible prevalence of anti-vax/vaccine skepticism, you can never be sure. I thought clarifying could be helpful!

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#188

Post by CyberDildonics »

crmd wrote: post #108
more_corn wrote: post #33

Earlier quoted context omitted.

[flagged]

I had kidney stone surgery (laser lithotripsy) in Manhattan last Friday morning and literally the first thing I was given after changing into the paper gown was 2 500mg Tylenol pills and a cup of water. I don’t know if you’re a physician but the medical staff in manhattan tend to be at the top of their game, and they are cool with Tylenol.

Are you saying one of the most used drugs on the planet is safe just because someone gave it to you in manhattan?

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#189

Post by laughing_man »

Terr_ wrote: post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

Tylenol is unusual among OTC medications in that you can get liver damage from as little as double the recommended dosage. It doesn't play well with alcohol, either. I wonder how many of those liver failures are the result of people drinking and taking too much of the drug either because the alcohol causes them to lose track, or from the alcohol interaction itself.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#190

Post by jurking_hoff »

akk0 wrote: post #158
crmd wrote: post #108

Earlier quoted context omitted.

I had kidney stone surgery (laser lithotripsy) in Manhattan last Friday morning and literally the first thing I was given after changing into the paper gown was 2 500mg Tylenol pills and a cup of water. I don’t know if you’re a physician but the medical staff in manhattan tend to be at the top of their game, and they are cool with Tylenol.

Being safe acutely after surgery does not necessarily translate into being healthy over decades when habitually used as a hangover cure.

[dead]
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