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Toothpaste made with keratin may protect and repair damaged teeth: study

kcl.ac.uk

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Re: Toothpaste made with keratin may protect and repair damaged teeth: study

#181

Earlier quoted context omitted.

https://betterbiom.com/products/nobs-toothpaste-tablets

Nobs is good because they only use rod-shaped NHA, not needle-shaped NHA which has a worse safety profile. Safety profile is important for anything nano

Is there anywhere I can learn more about NHA shapes? I currently use Apagard Renamel.

Re: Toothpaste made with keratin may protect and repair damaged teeth: study

#182
post #135
post #126

Earlier quoted context omitted.

I guess it implies human hair.

FWIW, I did not assume human hair.

Human hair is probably easiest to source in quantity, given it is a waste product in hair dressers world wide. Other current uses are wigs, and cleaning oil spills.

Re: Toothpaste made with keratin may protect and repair damaged teeth: study

#183
Think about it, the human genome already contains genetic encoding of keratin, it wouldn't have to evolve (incrementally bruteforce) a full protein code to "protect and repair" damaged teeth. It would just need to "happen onto" accidentally expressing it somewhere in the mouth: perhaps the mucous membrane lining the inside cheeks, perhaps the tongue, perhaps some glands in the mouth. Accidentally expressing a gene in a cell type that didn't before is much easier to occur (i.e. more likely) than generating a new functional protein: all it takes is a change in the binding site (or promoter region) so that the relevant cell type (say lining the mouth) would express it, conditionally or unconditionally.

If this were effective, our bodies would probably be doing it already.

Just to clarify: even if 2 people had the exact same genetic coding for proteins, but different coding of promoter regions, then these will have different binding affinities, modulating when proteins will or wont be expressed and at what rate. So when considering a population's genome statistics, there is already a spectrum of promotor region codes in the population, if this keratin presence on teeth had significant advantage, selection pressure would already have increased that level towards optimum.

The only caveat for my reasoning would be if it were discovered that this is exactly what happens in a healthy mouth, and that we recently discovered that conventional toothpastes have been stripping such layer of keratin by abrasion.

Re: Toothpaste made with keratin may protect and repair damaged teeth: study

#184
post #4

Was thinking about oddities of language recently (happens a lot since moving to Germany), specifically how "toothpaste" isn't made from teeth and "tomato paste" isn't something you rub onto a tomato. So anyway, should we be calling this "hairpaste for teeth", or "toothpaste from hair"?

And "pasta" is just the Italian word for paste.

Re: Toothpaste made with keratin may protect and repair damaged teeth: study

#185
post #172

Earlier quoted context omitted.

It depends on the country also. In the UK for example, Repair & Protect uses novamin but in the US it just uses stannous fluoride.

I think Canada has it with Novamin, while the US doesn't. The Netherlands does, and Germany doesn't. All with the same "repair & protect" name. It's puzzling. Now Germany does have it under a new "clinical repair" name, of course the "clinical" ones in the US do not, those do contain soap for some reason (sodium lauryl sulfate) which I don't think I've seen in any other country.

I actually started using Sensodyne because of the lack of SLS. I'm not in the US though.

Re: Toothpaste made with keratin may protect and repair damaged teeth: study

#187
post #5

>While fluoride toothpastes are currently used to slow this process, keratin-based treatments were found to stop it completely. That's really great I hope to use this some day.

Sensodyne toothpaste has two lines: one that contains a mild painkiller (Rapid Relief) and one that [claims to] repair small cracks in teeth (Repair & Protect). I use the latter. I do not know if it works, but I use it. I have never suffered from tooth pain before or after.

I found out the hard way that my mouth really doesn't like having SLS in it because I bought the wrong version of Sensodyne once. The "Pronamel" version is the only one I'm sure doesn't have SLS.

Regular Sensodyne in other countries has novamin though, and does not have SLS. I've brought home a few tubes from traveling and it seems to work just as well as the US version - I don't get sensitivity back when using it.

Re: Toothpaste made with keratin may protect and repair damaged teeth: study

#188

Earlier quoted context omitted.

I think Canada has it with Novamin, while the US doesn't. The Netherlands does, and Germany doesn't. All with the same "repair & protect" name. It's puzzling. Now Germany does have it under a new "clinical repair" name, of course the "clinical" ones in the US do not, those do contain soap for some reason (sodium lauryl sulfate) which I don't think I've seen in any other country.

I actually started using Sensodyne because of the lack of SLS. I'm not in the US though.

Be careful, they add SLS to several versions of their products in the US.

Re: Toothpaste made with keratin may protect and repair damaged teeth: study

#189

How does this compare with nano-hydroxyapatite, which is the current rage in toothpaste innovation and remineralization?

nHA is prohibitively expensive to produce and the most effective process that produces the smallest particles is patent-protected by Sangi, and therefore many nHA toothpaste brands only contain a fraction of the concentration used to produce the effective results reported in academic studies (1-2% instead of 10%). If keratin toothpastes can be produced more economically they could be a better option for mass adoption…

First time I've heard about apagard royal. In India it costs ₹5145 or $60 appprox.

Thats... substantially more expensive than regular toothpaste. Which costs ₹100-₹200 or $2-3.

Re: Toothpaste made with keratin may protect and repair damaged teeth: study

#190

Earlier quoted context omitted.

NHAP particles are smaller than fluoride particles, so they're able to penetrate farther into the porous surface of the teeth; flouride basically can only coat the surface. There is some research indicating that NHAP is more effective than flouride at remineralizing (e.g. https://pmc.ncbi.nlm.nih.gov/articles/PMC4252862/ ) but that flouride is more protective than NHAP because NHAP isn't protective at all. (The flour…

>Dave's toothpaste has both NHAP and flouride And has an RDA of 101. Why on earth would a toothpaste meant for sensitivity have this high of an RDA? (Non-whitening sensodyne is around the 40s)

After doing some research, I decided to go for this one: https://drjennatural.com/products/dr-jen-super-paste-with-na.... 10% nHAP (rod-shaped), RDA under 50 (exact number unspecified), nothing obviously objectionable in the ingredients, and comes with or without fluoride. My only minor quibble is that I couldn't determine the exact range of HAP particle sizes, which some other vendors do list. On the other hand, it has some strong reviews that seem credible, and there aren't many other options that explicitly provide 10% nHAP with a low RDA, and even fewer that offer a fluoridated version on top of that.

SuperMouth also looked like a great option with an RDA of 67 (particularly for kids who like crazy flavors), and Elims also looked good for anyone who doesn't mind the 92.71 RDA. Ollie stood out for its minimal ingredients list, but turned out to have a relatively high RDA of 143.

I currently use BioMin C in the morning and F at night, but based on everything I'm learning right now about nHAP, I figure it can't hurt to stack Dr. Jen with those. Maybe in a few years I'll get some keratin in the mix too.

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