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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#181

Post by throwawaylaptop »

XorNot wrote: post #162
throwawaylaptop wrote: post #151

Earlier quoted context omitted.

Inaccurate in my opinion. Let's say you eat 2500 calories a day usually. But you want to lose weight so you reduce it to 1800. Except your calories are from pop tarts. If you ate 100 calories of pop tarts every hour you're awake for total of 1800 calories... At the end of the month you'd be fatter. If you ate 1800 calories of pop tarts once a day in 1 hour, you might maintain weight or loose a little. Maybe. If you h…

> If you ate 100 calories of pop tarts every hour you're awake for total of 1800 calories... At the end of the month you'd be fatter. This is thermodynamically impossible unless your daily calorie use is less then 1800 calories.

Are you saying raising your insulin levels hourly, 18 times a day, will not do anything to your metabolism? Did you even read my post, or did you just instantly reply with the same pedantic reply which my post was specifically meant to address?

Re: Ozempic shows anti-aging effects in trial

#182

Post by leidenfrost »

throwawaylaptop wrote: post #151
leidenfrost wrote: post #126

Earlier quoted context omitted.

But it's not. What you're referring to, is the basic concept of thermodynamic calorie in/calorie out. Yes, you can "just" reduce food and lose weight if you hit deficit numbers. But if you don't do it correctly, you'll feel like trash, you'll suffer bad cravings, and put yourself in a stressful mental situation for days, possibly putting your job at risk. You have to: - Eat less than what you're already eating - But…

Inaccurate in my opinion. Let's say you eat 2500 calories a day usually. But you want to lose weight so you reduce it to 1800. Except your calories are from pop tarts. If you ate 100 calories of pop tarts every hour you're awake for total of 1800 calories... At the end of the month you'd be fatter. If you ate 1800 calories of pop tarts once a day in 1 hour, you might maintain weight or loose a little. Maybe. If you h…

Insulin control is about managing hunger more than a direct cause for weight.

You don't even need to do keto or wacky "just meat" diets to handle insulin. Protein consumption prevents insulin spikes for around 1-2 hours after eating. Also, proteins and fats slow down digestion.

Turns out, the good old Mediterranean diet is spot-on for a healthy lifestyle.

Re: Ozempic shows anti-aging effects in trial

#183

Post by throwawaylaptop »

tuesdaynight wrote: post #174
throwawaylaptop wrote: post #142

Earlier quoted context omitted.

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

Just scale that solution to millions of people and the comparison will be relevant.

If you told millions of people that bread, sugar, pasta and bread are basically killing them, and to flat out stop eating them.. you probably would help people lose weight (and save many lives too).

My dad has finally understood that grains are for people that need help maintain weight or gaining weight.

No fat person should ever be eating them.

Re: Ozempic shows anti-aging effects in trial

#184

Post by davorak »

jvanderbot wrote: post #125
blitzar wrote: post #116

Earlier quoted context omitted.

We must live on different timelines. Pre ozempic America was the proudest nation of fat people I have ever encountered (excluding the costal elites of course).

It's weird because I agree with you, but also have to acknowledge that the "pushback against fat phobia" was for some reason a thing.

Third American here, and the push for fat acceptance was so little of my media consumption that it surprised me so many people spent so much time and energy on the topic.

Re: Ozempic shows anti-aging effects in trial

#185

Post by throwawaylaptop »

radiofreeeuropa wrote: post #173
throwawaylaptop wrote: post #142

Earlier quoted context omitted.

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

There's anecdotes, and there's science. Individually, there's (previously) been nothing better to suggest than "try harder (and, maybe, smarter)". Statistically it was almost useless, but it's the best we had. It's not bad advice exactly, it's just extremely unlikely to work for long-term, sustained weight loss. It also very much appears to be the case that weight gain and loss are heavily influenced by environmental…

[flagged]

Re: Ozempic shows anti-aging effects in trial

#186

Post by kulahan »

pessimizer wrote: post #158
const_cast wrote: post #99

Earlier quoted context omitted.

Ive heard this same sentence, verbatim, repeated throughout the course of decades for particular fad diets. Decades .

The irony is that all that "it's so easy" "it's just calories in, calories out" "if you eat according to this plan and make sure to get 8 hours of sleep a day, you won't even feel the cravings" Is stuff that fat people say. They totally buy into it and buy all of the products to help them convince themselves this is true. Then they get disillusioned when it doesn't work, have a crisis of faith, then go to the next fa…

I’m certain IF more closely resembles how humans ate for millions of years, not knowing when our next meal would come before becoming an agrarian society, and we haven’t had much time to evolve since then.

So, yeah, dieting is modern, but so is an abundance of food. Both are equally unnatural.

Re: Ozempic shows anti-aging effects in trial

#187

Post by radiofreeeuropa »

throwawaylaptop wrote: post #185
radiofreeeuropa wrote: post #173

Earlier quoted context omitted.

There's anecdotes, and there's science. Individually, there's (previously) been nothing better to suggest than "try harder (and, maybe, smarter)". Statistically it was almost useless, but it's the best we had. It's not bad advice exactly, it's just extremely unlikely to work for long-term, sustained weight loss. It also very much appears to be the case that weight gain and loss are heavily influenced by environmental…

[flagged]

Run a study of your approach and show good results over a cohort for 2+ years and you'll make an entire sub-field of medical scientists very happy.

[EDIT] It's not that your approach can't work, it's that if (for example) people had as hard a time following the directions for condoms as they do following diet & workout plans, we'd never allow condoms to be sold as contraceptives, they'd not even be close to being OK to promote as useful for that purpose. It wouldn't matter if a few people could follow the directions and it worked 100% of the time for them.

Re: Ozempic shows anti-aging effects in trial

#188

Post by bobsmooth »

y-curious wrote: post #56
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I am one of those people to some extent. For me, it's the naturalistic fallacy I can't get over. I drink caffeine daily, but the idea of hijacking my hunger with an injectable induces dread. I would like to believe that there are no long-term side effects, but: 1. We have to trust the data of for-profit pharmaceutical companies and their trials. They are incentivized to produce optimistic results. 2. It's relatively…

>It is/was made of a poison from an animal.

Caffeine is an insecticide.

Re: Ozempic shows anti-aging effects in trial

#189

Post by snek_case »

mullingitover wrote: post #135
matwood wrote: post #68

Earlier quoted context omitted.

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

The cynic in my thinks this will its undoing. Some huge fraction of alcohol profits come from a small portion of drinkers. If these G* peptides help these poor people their drinking under control, it would take a huge wrecking ball to the profits, and thus to the taxes. Can't have that.

They're very expensive drugs so it would be one lobby against another. However given that they're so expensive, I would think that broke, uneducated alcoholics just won't have access to them, so those profits are safe...

Re: Ozempic shows anti-aging effects in trial

#190

Post by bobsmooth »

neves wrote: post #43

Be very cautious with these miracle drug headlines. There's a strong financial incentive to highlight only the good news. My mother, a healthy and active 87-year-old, started taking Ozempic because she was overweight and her doctor was impressed by the drug’s supposed miracles. She ended up suffering from severe intestinal motility issues, went through a lot of pain, and had to be admitted to the ICU. The long-term s…

You don't think her being 87 might have something to do with her complications?
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