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Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

medicalxpress.com

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Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#181

Post by johnisgood »

dur-randir wrote: post #151
aranchelk wrote: post #118

Earlier quoted context omitted.

It’s not just the syntax. Regex isn’t directly composable (unless you just mash together strings). They cannot define nested structures, I.e. no recursion. They can’t maintain context. We don’t need better language tools. Better parsers can, and already have, been implemented in libraries. I’d have a look at parser combinators.

(?R) is very much recursion in there.

> They can’t maintain context.

Is true though, or perhaps "state"? I know I had to come up with an algorithm because regexp alone couldn't do what I wanted (not even advanced features like lookahead, lookbehind, etc.)

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#182

Post by cosmie »

vlovich123 wrote: post #179
thom wrote: post #7

Delighted to discover this kind of breakthrough is based on a gnarly regular expression: https://github.com/Svensson-Lab/pro-hormone-predictor/blob/m...

> The study would not have been possible without the use of artificial intelligence to weed through dozens of proteins in a class called prohormones. I see we’re being fast and loose with the term “artificial intelligence”?

Could be that they relied on AI to generate the gnarly regex ¯\_(ツ)_/¯

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#183

Post by ddalex »

cosmie wrote: post #182
vlovich123 wrote: post #179

Earlier quoted context omitted.

> The study would not have been possible without the use of artificial intelligence to weed through dozens of proteins in a class called prohormones. I see we’re being fast and loose with the term “artificial intelligence”?

Could be that they relied on AI to generate the gnarly regex ¯\_(ツ)_/¯

Any sufficiently advanced regex is indistinguishable from AI.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#184

Post by s1artibartfast »

mikenew wrote: post #138
crazygringo wrote: post #116

Earlier quoted context omitted.

It's nearly always a side effect of weight loss, and it's a good thing. It's confusing how people act like it's bad. If you're obese, your legs are enormously strong with crazy amounts of muscle. Have you ever seen someone obese do leg presses at the gym? They can handle tons of weight. When you lose weight, you don't need all that extra muscle . If you're carrying around 180 lbs instead of 300 lbs on your frame, all…

That is absurd. Muscle mass is a huge predictor of mortality and anyone who isn't actively strength training and maintaining higher levels of muscle would see a health benefit by doing so. The idea that an overweight person has "too much muscle" is nonsense. The side affect of muscle loss from these glp-1 agonist drugs is a serious downside that everyone should be aware of and try to mitigate if they choose to take t…

There is a huge conflation of cause and effect with respect to muscle mass and longevity.

Low muscle mass is associated a broad swath of illnesses, low activity, and generally poor health.

Muscle mass's power as a predictor is not the same as it's utility as an intervention.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#185

Post by thayne »

Since it is naturally occurring, it isn't patentable. Which means it is less likely that companies will develop a commercial product from it.

Why pay to get FDA approval, if you don't get a government granted monopoly on it afterwards?

This is one problem with using patents as the mechanism to incentivise development of medicine.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#186

Post by wslh »

ddalex wrote: post #183
cosmie wrote: post #182

Earlier quoted context omitted.

Could be that they relied on AI to generate the gnarly regex ¯\_(ツ)_/¯

Any sufficiently advanced regex is indistinguishable from AI.

Even simple regex ones, since we don't know if they were created by a human or an AI.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#187

Post by Wilduck »

TheRealPomax wrote: post #150
ge96 wrote: post #146

Earlier quoted context omitted.

Is that an anti-pattern to put the comment inside the function vs above

Function documentation goes inside functions in Python, explicitly making them self-documenting. That can then be automatically picked up by any other code (like tooling for automatically generating API documentation) formalized as PEP 257, https://peps.python.org/pep-0257 Python will literally assign the content of your docstring (a triple-quoted string at the start of a function) to a special double underscored ("d…

> type `print(function_name.__doc__)`

Or even easier: `help(function_name)`!

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#189

Post by s1artibartfast »

hombre_fatal wrote: post #176
borgdefenser wrote: post #42

Earlier quoted context omitted.

Lean mass is just non-fat mass. That includes much more than just muscle. I can't find any evidence that GLP-1 are catabolic to muscle mass. There is no evidence I can find that GLP-1s do anything above what calorie restriction does. There is a linear relationship between calorie restriction and fat loss down to under 10% body fat. There is so much wrong information on calorie restriction from studies done on people…

Yeah, I just went down a rabbit hole re-looking this up myself. It seems that there's nothing unique about semaglutide, and %FFM loss is just a function of how rapidly you lose weight. The most rapid losers on semaglutide have the same %FFM loss (30%) as bariatric patients, for example. And if you don't want to lose weight that fast, you can just temper the dose (unlike with bariatric surgery).

Or eat protein and exercise.

I think it's extremely probable that the most rapid losers are running the largest calorie deficit and also the largest protein deficit.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#190

Post by ramoz »

thayne wrote: post #185

Since it is naturally occurring, it isn't patentable. Which means it is less likely that companies will develop a commercial product from it. Why pay to get FDA approval, if you don't get a government granted monopoly on it afterwards? This is one problem with using patents as the mechanism to incentivise development of medicine.

The article did refer to patents.

https://patents.google.com/?inventor=Katrin+Svensson

It would seem they are modifying peptides. Which is patentable.

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