Brain waves appear to wash out waste during sleep in mice

Post by walleeee » Sat, Mar 16, 2024, 6:47 PM UTC

niemandhier wrote: post #90

SturgeonsLaw wrote: post #49

Earlier quoted context omitted.

> Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude, rhythmic and self-perpetuating ionic waves in the interstitial fluid of the brain This line is the money shot. An action potential is the variable electrical charge of a neuron, and they maintain that charge by containing a certain concentration of ions relative to the surrounding cerebrospinal fluid. This p…

I’d expect that it’s probably not the ion movement but the global electric field, maybe even mechanical effects in the axons. If you look at the Goldstein-Katz equations you see that the conductivities play an as important role as the concentrations. Most of the voltage change is driven by changes in conductivities and not concentration changes, the ion movements across the membrane should be negligible. Off course y…

Post by ajb » Sat, Mar 16, 2024, 6:51 PM UTC

magicalhippo wrote: post #175

zachkatz wrote: post #171

Earlier quoted context omitted.

If the problem is psychological trauma, wouldn’t therapy be the obvious solution?

The root cause is psychological, but it's manifested itself in physical changes. She's hyper-sensitive to certain sounds for example, which causes her to not be able to fall asleep, or to abruptly wake up. Mostly low frequency sounds, so hard to block. But yeah, as I mention in a reply to a sibling comment, she's tried therapy for years without much progress, though recently making some progress on that front.

Post by verticalscaler » Sat, Mar 16, 2024, 6:59 PM UTC

magicalhippo wrote: post #175

zachkatz wrote: post #171

Earlier quoted context omitted.

If the problem is psychological trauma, wouldn’t therapy be the obvious solution?

The root cause is psychological, but it's manifested itself in physical changes. She's hyper-sensitive to certain sounds for example, which causes her to not be able to fall asleep, or to abruptly wake up. Mostly low frequency sounds, so hard to block. But yeah, as I mention in a reply to a sibling comment, she's tried therapy for years without much progress, though recently making some progress on that front.

Post by sonofhans » Sat, Mar 16, 2024, 7:17 PM UTC

mattlondon wrote: post #53

_y5hn wrote: post #35

Earlier quoted context omitted.

That's been in use for thousands of years already: yoga, pranayama and meditation. There are courses one can take where one learns this, like Art of Living and any other that follows the same traditions. Yes, there's research on that, and new studies should absolutely gain from this study. Not entirely sure you'll observe the same effect, that depends on meditator, but you can fall asleep during practice. I have over…

I think the point of replacing sleep is to save time. Replacing hours of sleep with hours of yogo or mediation seems like you are not gaining anything.

Post by Terr_ » Sat, Mar 16, 2024, 7:27 PM UTC

moffkalast wrote: post #124

robg wrote: post #87

If you have any doubts about sleep quantity and quality, worth reading about the glymphatic nervous system, which is so newly discovered likely you didn’t learn about it in school. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/ In short it explains, mechanistically, why poor sleep affects daily cognition, mental health, and age-related declines. Robust scientific theories explain more of the evidence. The glym…

I wonder if eventually once this is more thoroughly researched there could be a way to induce constant cleaning instead of having to do it while unconscious at night? Or at least reduce the hours required. If we could solve this we could just stay awake perpetually and instantly gain a 30% longer lifespan as it were.