Bloomberg's headline very different vs the actual conclusion of the study: "Young males might be particularly susceptible to the effects of cannabis on schizophrenia. At a population level, assuming causality, one-fifth of cases of schizophrenia among young males might be prevented by averting CUD. Results highlight the importance of early detection and treatment of CUD and policy decisions regarding cannabis use and access, particularly for 16–25-year-olds."
Heavy marijuana use increases schizophrenia in men, study finds
181–190 of 304 posts
Re: Heavy marijuana use increases schizophrenia in men, study finds
#182You have these cells in your brain called Microglia. They are responsible for cleaning up neurons and plaques and other weird proteins. These Microglia are activated by the firing neurons which release 2-AG and AEA (Anadamide). AEA binds to the CB1 receptor in these Microglia. 2-AG binds to CB2. THC binds to CB1. CBD binds to CB2. Autistic adults have significantly low blood serum levels of AEA. Autistic people’s neu…
FAAH inhibitors sound like a good idea .
… Sure… if you want to avoid the “side effects” of the current obviously available treatment options. :p
Re: Heavy marijuana use increases schizophrenia in men, study finds
#183Earlier quoted context omitted.
> schizophrenic people are drawn to cannabis This sounds a lot like saying that people with a predisposition to lung cancer are drawn to cigarettes.
My understanding is that schizophernia is a predisposed condition. Cannabis can trigger it but not really cause it. (That's at least what I got from talking to a professional). One clue to find out whether you are predisposed is if you have someone in the family (related genetically) who has at-birth mental health issues. Then stay a gazillion miles clear of any drugs.
If you don’t have it and then taking it makes you have it then that is causing it
Re: Heavy marijuana use increases schizophrenia in men, study finds
#184You have these cells in your brain called Microglia. They are responsible for cleaning up neurons and plaques and other weird proteins. These Microglia are activated by the firing neurons which release 2-AG and AEA (Anadamide). AEA binds to the CB1 receptor in these Microglia. 2-AG binds to CB2. THC binds to CB1. CBD binds to CB2. Autistic adults have significantly low blood serum levels of AEA. Autistic people’s neu…
So Schizophrenia is the opposite of Autism?
there is a theory along these lines. something like: the defense against the unconscious is so strong in autism that the person becomes rigid and shut off. the defense against the unconscious is so weak in schizophrenia that the person is overwhelmed with phenomena. but both have something to do with intense unconscious objects.
Re: Heavy marijuana use increases schizophrenia in men, study finds
#185Earlier quoted context omitted.
> schizophrenic people are drawn to cannabis This sounds a lot like saying that people with a predisposition to lung cancer are drawn to cigarettes.
My understanding is that schizophernia is a predisposed condition. Cannabis can trigger it but not really cause it. (That's at least what I got from talking to a professional). One clue to find out whether you are predisposed is if you have someone in the family (related genetically) who has at-birth mental health issues. Then stay a gazillion miles clear of any drugs.
> at-birth mental health issues
many of the most common mental health conditions (personality disorders, and schizophrenia) don't appear till the end of adolescence.
Re: Heavy marijuana use increases schizophrenia in men, study finds
#186Earlier quoted context omitted.
> schizophrenic people are drawn to cannabis This sounds a lot like saying that people with a predisposition to lung cancer are drawn to cigarettes.
My understanding is that schizophernia is a predisposed condition. Cannabis can trigger it but not really cause it. (That's at least what I got from talking to a professional). One clue to find out whether you are predisposed is if you have someone in the family (related genetically) who has at-birth mental health issues. Then stay a gazillion miles clear of any drugs.
> My understanding is that schizophernia is a predisposed condition. Cannabis can trigger it but not really cause it.
If something is flammable, and so predisposed to burning, and you hold a lit match to it, you did cause the fire. You didn't just trigger it.
Re: Heavy marijuana use increases schizophrenia in men, study finds
#187Earlier quoted context omitted.
My understanding is that schizophernia is a predisposed condition. Cannabis can trigger it but not really cause it. (That's at least what I got from talking to a professional). One clue to find out whether you are predisposed is if you have someone in the family (related genetically) who has at-birth mental health issues. Then stay a gazillion miles clear of any drugs.
> My understanding is that schizophernia is a predisposed condition. Cannabis can trigger it but not really cause it. If something is flammable, and so predisposed to burning, and you hold a lit match to it, you did cause the fire. You didn't just trigger it.
This is a weird argument, because “trigger” and “cause” here are exact synonyms.
Re: Heavy marijuana use increases schizophrenia in men, study finds
#188You have these cells in your brain called Microglia. They are responsible for cleaning up neurons and plaques and other weird proteins. These Microglia are activated by the firing neurons which release 2-AG and AEA (Anadamide). AEA binds to the CB1 receptor in these Microglia. 2-AG binds to CB2. THC binds to CB1. CBD binds to CB2. Autistic adults have significantly low blood serum levels of AEA. Autistic people’s neu…
> Autistic adults have significantly low blood serum levels of AEA. Autistic people’s neurons prune slower. Schizophrenic people’s neurons prune faster.
These are all group-level findings, meaning they aren't true for every individual. You can do a study and find that there is a statistically significant difference in mean X between two samples – autistic vs control or schizophrenic vs control. But pretty much always, although there is a statistically significant difference in the mean, the two samples overlap – which is consistent with this being a factor which only explains some of the cases.
> It seems the ECS system is the principal driving mechanism behind both conditions.
Claims like that ("the principal driving mechanism behind psychiatric diagnosis X is biological difference Y") have been made many times before, and few of them have gone anywhere. I'd be surprised if this one turns out differently.
Both autism and schizophrenia are bundles of different conditions which we've grouped together on the basis of nothing more than overlapping systems. Two people can both have "autism", yet at a biological level they've got two completely different things. The same applies for two people with "schizophrenia". This is why a number of researchers have been arguing that diagnosis-centric research is a dead-end.
I wouldn't be surprised if ECS system issues (or any other system in the brain) turn out to be the cause of some cases of autism and some cases of schizophrenia; but there will be other cases of both in which it isn't the "principal driving mechanism" at all.
Re: Heavy marijuana use increases schizophrenia in men, study finds
#189Earlier quoted context omitted.
So Schizophrenia is the opposite of Autism?
there is a theory along these lines. something like: the defense against the unconscious is so strong in autism that the person becomes rigid and shut off. the defense against the unconscious is so weak in schizophrenia that the person is overwhelmed with phenomena. but both have something to do with intense unconscious objects.
Do you have a source for these claims? Would be super interested in reading more on this.
Re: Heavy marijuana use increases schizophrenia in men, study finds
#190You have these cells in your brain called Microglia. They are responsible for cleaning up neurons and plaques and other weird proteins. These Microglia are activated by the firing neurons which release 2-AG and AEA (Anadamide). AEA binds to the CB1 receptor in these Microglia. 2-AG binds to CB2. THC binds to CB1. CBD binds to CB2. Autistic adults have significantly low blood serum levels of AEA. Autistic people’s neu…
Empirically (based on my own observations) I've known for decades that weed induced episodes in schizophrenic people. I didn't know it was helpful for autistic people. On the same (personal observation) basis, I'd say that schizophrenic people are drawn to cannabis. I have no idea why; perhaps because they're often very marginalized and precarious.
Schizophrenic people are also very often smokers, but there's a good reason for this; nicotine is actually a very effective treatment for schizophrenia symptoms, better than the actual medicines.
(Of course, smoking is still bad for you.)