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Fentanyl vaccine tested in rats

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Re: Fentanyl vaccine tested in rats

#181

Post by cmyr »

patientplatypus wrote: post #142
shaunxcode wrote: post #109

The real issue here that people don't seem to want to face is the WHY. Why do so many people want to check out of life completely by abusing medicine? If we don't address that nothing is going to stop the drug abuse let alone the relapse and overdose. I'm not talking about "more 12 step" here but more of a Frommian psychoanalytic approach. You are broken because society is broken. You have the ability to change yours…

I'm homeless and living in the Tenderloin in San Francisco. People here want you to - Be in a gang (or a prostitute, thief, ex-con and so forth) - Be on drugs (or in rehab for drugs) - Have a mental illness (so you can go to therapy) - Be disabled - Find religion There isn't a position for "I ran out of money and my family wouldn't support me, and at some point finding web development work became too hard as the tech…

Thank you for sharing. I'm sorry.

Re: Fentanyl vaccine tested in rats

#182

Post by HEmanZ »

fasthands9 wrote: post #112
shaunxcode wrote: post #109

The real issue here that people don't seem to want to face is the WHY. Why do so many people want to check out of life completely by abusing medicine? If we don't address that nothing is going to stop the drug abuse let alone the relapse and overdose. I'm not talking about "more 12 step" here but more of a Frommian psychoanalytic approach. You are broken because society is broken. You have the ability to change yours…

I guess I'm a bit torn on this. Even if we had an extremely fair and equitable society with growth I imagine there'd still be plenty of people who feel rejected or lonesome at times. Or just like the feeling that these drugs give them above normal drugs. I drink alcohol a couple times a week and do edibles once a month. I'm sure some would argue I'm not fulfilled but I think the easier explanation is that a lot of ti…

I have known quite a few friends from earlier in my life who became serious addicts and ruined their lives or ended their lives by it. I would not describe a single one as having started using because they were mad at society, sad, or lonesome. It was always some strange kind of strange, arrogant fetishization of drug-life and crime-life. There is an almost "drug life is THE life, and everyone else is lame" attitude in many circles, and I got a little too close to comfort to falling into it at one point in my life.

This doesn't mean there aren't a hundred reasons people get trapped in drugs. But a very real one is just because many people come to believe it's cool and tough, and end up fetishizing it until it's too late to get out. And like I said, in my hometown, this was the predominant reason.

Re: Fentanyl vaccine tested in rats

#183

Post by 71a54xd »

As someone who's not a drug addict or around people who use substances that might be tainted with it, I don't want this. If I'm in a car accident or a serious condition where I need immensely powerful pain-killers I sure as you know what want Fentanyl to work.

Re: Fentanyl vaccine tested in rats

#184

Post by encoderer »

anonymouskimmer wrote: post #172
encoderer wrote: post #135

Earlier quoted context omitted.

Humans were not evolved to resist these kinds of poisons. Nothing like this exists in nature. It’s an extremely potent chemical.

It's not that nothing like this exists in nature, it's that evolutionarily speaking nothing like this existed in the areas human first evolved. Or if they did, we either evolved to resist them, thus no longer see them as toxic, or we're still in an arms race with the life that produces them (which means they would be much less toxic than fentanyl, but still toxic). Plants (and fungi, and animals) evolved to create no…

The golden poison frog looks pretty scary to me. The yellow color. The big eyes. I would not try to eat it. But a white powder or pill that is equally lethal doesn’t ring any evolutionary alarm bells.

Re: Fentanyl vaccine tested in rats

#185

Post by makestuff »

hammock wrote: post #177
kstrauser wrote: post #118

Earlier quoted context omitted.

They’re adding Fentanyl to everything now. I have Burning Man-adjacent friends who take ecstasy once a year at festivals, and they’re terrified of getting a tainted dose. This affects many more people than just those addicted to opiates.

Test strips: https://dancesafe.org/ Or on amazon

They give these out in NYC, but make a point to say that the test strips won't catch everything. So still be really careful if you go this route.

Re: Fentanyl vaccine tested in rats

#186

Post by calibas »

htag wrote: post #170
calibas wrote: post #53

Oh boy, the pharmaceutical companies can sell a new product to help solve the mess that one of their previous products created. An opioid that's more potent, more addictive, and more deadly than heroin should never have gone to market in the first place. It speaks of enormous corruption and a complete lack of ethics when regulators didn't see an issue with fentanyl and let it move forward. The "but people are in pain…

> It speaks of enormous corruption and a complete lack of ethics when regulators didn't see an issue with fentanyl and let it move forward. Do you think there would be a meaningful difference in the volume of illicit fentanyl if it was never approved by the FDA?

If the manufacturers and regulators were more concerned with human lives than making money, they would have quietly buried the research. It may have entered the illegal market eventually, but there wouldn't be factories producing large quantities of the drug like there are now.

They should have known that an opioid 50 times more potent, deadlier, and more addictive than heroin would be responsible for the worst drug epidemic the world has ever seen.

Re: Fentanyl vaccine tested in rats

#187

Post by khazhoux »

sillysaurusx wrote: post #115
shaunxcode wrote: post #109

The real issue here that people don't seem to want to face is the WHY. Why do so many people want to check out of life completely by abusing medicine? If we don't address that nothing is going to stop the drug abuse let alone the relapse and overdose. I'm not talking about "more 12 step" here but more of a Frommian psychoanalytic approach. You are broken because society is broken. You have the ability to change yours…

Probably because it feels good. Sometimes the simple answers are the most likely. Even if you have a great life, it’s tempting to have such experiences. Sure, a lot of people use it as an escape though. But I imagine my dumbass brother in law died because he was trying to have fun, not check out of life. Miss him.

> Probably because it feels good.

This is the dirty little secret of 1980’s-style approach to keeping people off drugs: they feel great.

The old (current?) approach suffers from intellectual dishonesty of ignoring the physical pleasure.

Re: Fentanyl vaccine tested in rats

#188

Post by bobleeswagger »

cantSpellSober wrote: post #116
bobleeswagger wrote: post #111

Earlier quoted context omitted.

[flagged]

The COVID vaccine was designed to reduce the spread of an infectious disease, seems to fit the definition. Is there a different vaccine you refer to?

The COVID vaccine was designed to make an astronomical amount of money in a time of extreme inflation.

If it made society better by "preventing infectious disease" that was a side-effect.

Re: Fentanyl vaccine tested in rats

#189

Post by at_a_remove »

calibas wrote: post #53

Oh boy, the pharmaceutical companies can sell a new product to help solve the mess that one of their previous products created. An opioid that's more potent, more addictive, and more deadly than heroin should never have gone to market in the first place. It speaks of enormous corruption and a complete lack of ethics when regulators didn't see an issue with fentanyl and let it move forward. The "but people are in pain…

Eh. I'm an an antique Schedule II drug. The literature notes that people with my condition don't seem to end up addicted to said drug (or its pals). Probably because we're just glad to take the edge off the pain. It's already rather potent, as painkillers go, as it previously was given to women in labor.

However, as my condition becomes more severe, a time will come when I will have to "graduate" to something stronger. The end of that choo-choo train looks like fentanyl or something very much like it, assuming I don't just up and die first. I'm glad that there is something there.

A friend of mine, his mother died of the same thing many years ago, when it was poorly understood and largely untreated. She was kept in a distant corner of the house so that the screams were less bothersome. Raving in pain, she would curse his name for not helping her to die. That's what it looks like at the end when there's not enough painkillers.

So I guess if you get your way, can I bunk at your place?

I joke, but only a little. You don't have a lot of skin in this particular game. Consequences are far away, third-order at best. I dunno, maybe listening to someone howling away might bring it home, maybe not.

To someone like me, it looks like someone who won't really be affected at all just trying to yank one of the few solutions I have left away, and for no good reason at all.

Re: Fentanyl vaccine tested in rats

#190

Post by wdhilliard »

wswope wrote: post #133
wdhilliard wrote: post #75

Does this prevent death or just the perceived effects of the drug? This could be very dangerous for users who relapse. There is a known pattern of users who get off opioids then relapse and die because their bodies can no longer tolerate the doses that they were used to taking before they quit. This could have a similar effect where users take the drug, don't feel it, and then increase their dose to lethal levels hop…

Can you elaborate on your point of confusion? The mechanism of action was explained in the article.

My point of confusion is still my initial question. It was actually the description of the mechanism, as given, that had me questioning it's effects on the overall toxicity/danger of ingesting the drug.

"Our vaccine is able to generate anti-fentanyl antibodies that bind to the consumed fentanyl and prevent it from entering the brain, allowing it to be eliminated out of the body via the kidneys. Thus, the individual will not feel the euphoric effects and can ‘get back on the wagon’ to sobriety,” said the study’s lead author Colin Haile"

They clarify that this causes a user to not feel the positive effects of the drug, but I would assume that if the drug was also able to prevent overall mortality, they would be excited enough to mention it.

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